FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948767545> ?p ?o ?g. }

• W1948767545 abstract "Screening phenolic and polyphenolic compounds for inhibitory activity against electric eels acetylcholinesterase (AChE) identified baicalein, a major flavone derived from the roots of Scutellaria baicalensis, as the most potent inhibitor with IC50 (concentration required for 50% inhibition) of 0.61 µM. None of the hydroxybenzoic and hydroxycinnamic acids screened showed inhibitory activity measured at 100 µM. Structure-activity relationships based on IC50 values of the active flavonoids showed that inhibitory activity (a) required the unsaturated 2-phenyl-chroman structure, (b) has strong requirement for the A-ring A5-OH, A6-OH and A7-OH groups (b) does not depend on B-ring hydroxyl groups, and (d) was reduced by bulky sugar substitution of the saturated C-ring C3-OH. Enzyme kinetic analysis showed that baicalein is a mixed inhibitor of AChE with K1 (equilibrium constant of dissociation of the inhibitor bound enzyme complex) and K2 (equilibrium constant of dissociation of the inhibitor bound enzyme-substrate complex) of 0.91 and 1.98 µM, respectively." @default.
• W1948767545 created "2016-06-24" @default.
• W1948767545 creator A5000130166 @default.
• W1948767545 creator A5026763164 @default.
• W1948767545 creator A5031178621 @default.
• W1948767545 creator A5035179544 @default.
• W1948767545 date "2015-08-15" @default.
• W1948767545 modified "2023-10-16" @default.
• W1948767545 title "Screening Flavonoids for Inhibition of Acetylcholinesterase Identified Baicalein as the Most Potent Inhibitor" @default.
• W1948767545 cites W1516670331 @default.
• W1948767545 cites W1563671539 @default.
• W1948767545 cites W1967372871 @default.
• W1948767545 cites W1969793439 @default.
• W1948767545 cites W1971048984 @default.
• W1948767545 cites W1978971424 @default.
• W1948767545 cites W1995134802 @default.
• W1948767545 cites W2005483591 @default.
• W1948767545 cites W2017645489 @default.
• W1948767545 cites W2020820423 @default.
• W1948767545 cites W2041472962 @default.
• W1948767545 cites W2047420624 @default.
• W1948767545 cites W2067171548 @default.
• W1948767545 cites W2072219894 @default.
• W1948767545 cites W2073891844 @default.
• W1948767545 cites W2076466251 @default.
• W1948767545 cites W2084585115 @default.
• W1948767545 cites W2089835787 @default.
• W1948767545 cites W2090663532 @default.
• W1948767545 cites W2096410114 @default.
• W1948767545 cites W2137980672 @default.
• W1948767545 cites W2149098307 @default.
• W1948767545 cites W2158984087 @default.
• W1948767545 cites W2159866533 @default.
• W1948767545 cites W2330564257 @default.
• W1948767545 doi "https://doi.org/10.5539/jas.v7n9p26" @default.
• W1948767545 hasPublicationYear "2015" @default.
• W1948767545 type Work @default.
• W1948767545 sameAs 1948767545 @default.
• W1948767545 citedByCount "25" @default.
• W1948767545 countsByYear W19487675452017 @default.
• W1948767545 countsByYear W19487675452018 @default.
• W1948767545 countsByYear W19487675452019 @default.
• W1948767545 countsByYear W19487675452020 @default.
• W1948767545 countsByYear W19487675452021 @default.
• W1948767545 countsByYear W19487675452022 @default.
• W1948767545 countsByYear W19487675452023 @default.
• W1948767545 crossrefType "journal-article" @default.
• W1948767545 hasAuthorship W1948767545A5000130166 @default.
• W1948767545 hasAuthorship W1948767545A5026763164 @default.
• W1948767545 hasAuthorship W1948767545A5031178621 @default.
• W1948767545 hasAuthorship W1948767545A5035179544 @default.
• W1948767545 hasBestOaLocation W19487675451 @default.
• W1948767545 hasConcept C142724271 @default.
• W1948767545 hasConcept C150757390 @default.
• W1948767545 hasConcept C169760540 @default.
• W1948767545 hasConcept C170493617 @default.
• W1948767545 hasConcept C17077164 @default.
• W1948767545 hasConcept C181199279 @default.
• W1948767545 hasConcept C185592680 @default.
• W1948767545 hasConcept C188947578 @default.
• W1948767545 hasConcept C202751555 @default.
• W1948767545 hasConcept C204787440 @default.
• W1948767545 hasConcept C2776980637 @default.
• W1948767545 hasConcept C2777752497 @default.
• W1948767545 hasConcept C2778153525 @default.
• W1948767545 hasConcept C2778816929 @default.
• W1948767545 hasConcept C2779475777 @default.
• W1948767545 hasConcept C2781466915 @default.
• W1948767545 hasConcept C55493867 @default.
• W1948767545 hasConcept C71240020 @default.
• W1948767545 hasConcept C71924100 @default.
• W1948767545 hasConcept C74998103 @default.
• W1948767545 hasConcept C86803240 @default.
• W1948767545 hasConcept C98274493 @default.
• W1948767545 hasConceptScore W1948767545C142724271 @default.
• W1948767545 hasConceptScore W1948767545C150757390 @default.
• W1948767545 hasConceptScore W1948767545C169760540 @default.
• W1948767545 hasConceptScore W1948767545C170493617 @default.
• W1948767545 hasConceptScore W1948767545C17077164 @default.
• W1948767545 hasConceptScore W1948767545C181199279 @default.
• W1948767545 hasConceptScore W1948767545C185592680 @default.
• W1948767545 hasConceptScore W1948767545C188947578 @default.
• W1948767545 hasConceptScore W1948767545C202751555 @default.
• W1948767545 hasConceptScore W1948767545C204787440 @default.
• W1948767545 hasConceptScore W1948767545C2776980637 @default.
• W1948767545 hasConceptScore W1948767545C2777752497 @default.
• W1948767545 hasConceptScore W1948767545C2778153525 @default.
• W1948767545 hasConceptScore W1948767545C2778816929 @default.
• W1948767545 hasConceptScore W1948767545C2779475777 @default.
• W1948767545 hasConceptScore W1948767545C2781466915 @default.
• W1948767545 hasConceptScore W1948767545C55493867 @default.
• W1948767545 hasConceptScore W1948767545C71240020 @default.
• W1948767545 hasConceptScore W1948767545C71924100 @default.
• W1948767545 hasConceptScore W1948767545C74998103 @default.
• W1948767545 hasConceptScore W1948767545C86803240 @default.
• W1948767545 hasConceptScore W1948767545C98274493 @default.
• W1948767545 hasIssue "9" @default.
• W1948767545 hasLocation W19487675451 @default.
• W1948767545 hasOpenAccess W1948767545 @default.
• W1948767545 hasPrimaryLocation W19487675451 @default.

• next