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• W1948851598 abstract "Introduction: Orbitopathy associated with Graves’ disease TAO (thyroid associated orbitopathy) is likewise connected with environmental factors including tobacco smoking. Tobacco smoking increases the risk of ophthalmologic pathology and leads to the orbital tissue damage due to the hypoxia. The aim of the study was to correlate the concentration of urinecotinine (marker of tobacco smoking) in Graves’ disease patients with TAO with points received on the Fagerstrom questionnaire. Materials and methods: Thirty women with different degree of exacerbation of TAO in Graves’ disease (34.28 ± 12.04 yr.) were examined. As control we used 29 women with Graves’ disease without TAO (29.35 ± 12.33 yr.). The diagnosis was established according to level of TSH and level of thyrotropin receptor antibodies (TRAb). Measure of tobacco smoking or exposure to second hand tobacco smoke ETS (environmental tobacco smoke) carried out according to the Fagerstrom questionnaire, and measured cotinine level (the major metabolite of nicotine in urine). The level of clinical ophtalmopathy was measured according to the CAS (Clinical Activity Score) scale and degree of progression of TAO according to American Thyroid Association (NOSPECS scale). Additionally increase of exophthalmus was measured using the Hertl’s exophthalmometer. Results: In the group with TAO: 19 (63.3%) persons had mild exophthalmos (according to CAS), medium in 13 (43.3%) patients, and pronounced exophthalmous in 10 (33%) patients. There was statistically significant difference in the level of TRAb (18.4 ± 8.2 vs. 5.1 ± 3.4 IU/l; p 24 mm; ≥ 4 points according to CAS) and those without TAO (Mann-Whitney’s test p = 0.04). Conclusions: 1. In patients with Graves’ disease with TAO the highest score of tobacco smoking has been found in persons with the highest ophthalmopathy exacerbation. 2. Estimation of cotinine concentration in urine is the most objective and useful method of tobacco smoking. (Pol J Endocrinol 2006; 6 (57): 612–618)" @default.
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• W1948851598 date "2006-11-01" @default.
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• W1948851598 title "[The level of cotinine - marker of tobacco smoking, in patients with hyperthyroidism]." @default.
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