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• W1948852593 abstract "Prion diseases, or transmissible spongiform encephalopathies, are progressive, fatal neurodegenerative diseases. There are both human and animal forms of the disease and all are associated with the conversion of a normal host-coded cellular prion protein (PrPC) into an abnormal protease-resistant isoform (PrPSc). Although methodologies are sensitive and specific for postmortem disease diagnosis, the use of PrPSc as a preclinical or general biomarker for surveillance is difficult, due to the fact that it is present in extremely small amounts in accessible tissues or body fluids such as blood, urine, saliva, and cerebrospinal fluid. Recently, amplification techniques have been developed, which have enabled increased sensitivity for PrPSc detection. However, it has recently been reported that proteinase K sensitive, pathological isoforms of PrP may have a significant role in the pathogenesis of some prion diseases. Accordingly, the development of new diagnostic tests that do not rely on PrPSc and proteinase K digestion is desirable. The search for biomarkers (other than PrPSc) as tools for diagnosis of prion diseases has a long history. Ideally biomarkers able to detect all transmissible spongiform encephalopathies, even at preclinical stages of infection are desirable but not yet possible due to the heterogeneity of the disease and lengthy disease progression. Recent advances in neuroproteomics have led to an overwhelming amount of information, which may offer insight on protein–protein interactions. While the amount of data obtained is impressive, the ability to relate it to the disease and validating its usefulness in diagnostic biomarker development remains a formidable challenge." @default.
• W1948852593 created "2016-06-24" @default.
• W1948852593 creator A5087386244 @default.
• W1948852593 date "2012-11-23" @default.
• W1948852593 modified "2023-10-16" @default.
• W1948852593 title "Proteomic analysis of prion diseases: Creating clarity or causing confusion?" @default.
• W1948852593 cites W1486755788 @default.
• W1948852593 cites W1562167215 @default.
• W1948852593 cites W1584837735 @default.
• W1948852593 cites W1662968076 @default.
• W1948852593 cites W1764898023 @default.
• W1948852593 cites W1856002093 @default.
• W1948852593 cites W1902955342 @default.
• W1948852593 cites W1945769573 @default.
• W1948852593 cites W1947939951 @default.
• W1948852593 cites W1966658105 @default.
• W1948852593 cites W1967261289 @default.
• W1948852593 cites W1968733337 @default.
• W1948852593 cites W1970751208 @default.
• W1948852593 cites W1971564656 @default.
• W1948852593 cites W1972161622 @default.
• W1948852593 cites W1972644169 @default.
• W1948852593 cites W1972972841 @default.
• W1948852593 cites W1976038427 @default.
• W1948852593 cites W1979678617 @default.
• W1948852593 cites W1979856683 @default.
• W1948852593 cites W1979956614 @default.
• W1948852593 cites W1980030035 @default.
• W1948852593 cites W1980348131 @default.
• W1948852593 cites W1981570340 @default.
• W1948852593 cites W1982761768 @default.
• W1948852593 cites W1983111155 @default.
• W1948852593 cites W1985384585 @default.
• W1948852593 cites W1985630952 @default.
• W1948852593 cites W1987173512 @default.
• W1948852593 cites W1990496336 @default.
• W1948852593 cites W1990689284 @default.
• W1948852593 cites W1991424179 @default.
• W1948852593 cites W1992408091 @default.
• W1948852593 cites W1992666783 @default.
• W1948852593 cites W1993236921 @default.
• W1948852593 cites W1993292811 @default.
• W1948852593 cites W1995400471 @default.
• W1948852593 cites W1996181439 @default.
• W1948852593 cites W1997196023 @default.
• W1948852593 cites W2003156002 @default.
• W1948852593 cites W2007023132 @default.
• W1948852593 cites W2007309224 @default.
• W1948852593 cites W2007487855 @default.
• W1948852593 cites W2012292102 @default.
• W1948852593 cites W2012929467 @default.
• W1948852593 cites W2014043099 @default.
• W1948852593 cites W2014116107 @default.
• W1948852593 cites W2016751261 @default.
• W1948852593 cites W2017126556 @default.
• W1948852593 cites W2017785279 @default.
• W1948852593 cites W2017870593 @default.
• W1948852593 cites W2019169901 @default.
• W1948852593 cites W2020434254 @default.
• W1948852593 cites W2021181758 @default.
• W1948852593 cites W2021817081 @default.
• W1948852593 cites W2023158039 @default.
• W1948852593 cites W2023705678 @default.
• W1948852593 cites W2023766647 @default.
• W1948852593 cites W2024256697 @default.
• W1948852593 cites W2028429551 @default.
• W1948852593 cites W2028736548 @default.
• W1948852593 cites W2036887368 @default.
• W1948852593 cites W2037877748 @default.
• W1948852593 cites W2040452312 @default.
• W1948852593 cites W2040984993 @default.
• W1948852593 cites W2044715922 @default.
• W1948852593 cites W2048339382 @default.
• W1948852593 cites W2048460135 @default.
• W1948852593 cites W2053432495 @default.
• W1948852593 cites W2053459036 @default.
• W1948852593 cites W2053977509 @default.
• W1948852593 cites W2056932428 @default.
• W1948852593 cites W2058096709 @default.
• W1948852593 cites W2059121099 @default.
• W1948852593 cites W2062912493 @default.
• W1948852593 cites W2063139737 @default.
• W1948852593 cites W2063354139 @default.
• W1948852593 cites W2064722614 @default.
• W1948852593 cites W2065469060 @default.
• W1948852593 cites W2069409546 @default.
• W1948852593 cites W2070223219 @default.
• W1948852593 cites W2072404596 @default.
• W1948852593 cites W2074400407 @default.
• W1948852593 cites W2075187485 @default.
• W1948852593 cites W2076156582 @default.
• W1948852593 cites W2077887509 @default.
• W1948852593 cites W2080489609 @default.
• W1948852593 cites W2086565529 @default.
• W1948852593 cites W2087672655 @default.
• W1948852593 cites W2089199332 @default.
• W1948852593 cites W2089569305 @default.
• W1948852593 cites W2096678988 @default.

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