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• W1948902556 abstract "Abstract The first committed step in the purine de novo synthesis pathway is performed by amidophosphoribosyl-transferase (EC 2.4.2.14) or Prat. Drosophila melanogaster Prat is an essential gene with a promoter that lacks a TATA-box and initiator element and has multiple transcription start sites with a predominant start site. To study the regulation of Prat expression in the adult eye, we used the Prat:bw reporter gene, in which the Prat coding region was replaced with the brown (bw) coding region. The pale-orange eye color of a single copy of Prat:bw prompted us to use a multicopy array of Prat:bw that was derived using P transposase mutagenesis and produces a darker-orange eye color in a bwD; st genetic background. We used a 13-copy array of Prat:bw as a tool to recover dominant EMS-induced mutations that affect the expression of the transgene. After screening 21,000 F1s for deviation from the orange eye color, we isolated 23 dominant modifiers: 21 suppressors (1 Y-linked, 5 X-linked, 4 2-linked, and 11 3-linked) and 2 enhancers (1 2-linked and 1 3-linked). Quantification of their effect on endogenous Prat gene expression, using RT-PCR in young adult fly heads, identifies a subset of modifiers that are candidates for genes involved in regulating Prat expression." @default.
• W1948902556 created "2016-06-24" @default.
• W1948902556 creator A5022471681 @default.
• W1948902556 creator A5076834412 @default.
• W1948902556 date "2003-08-01" @default.
• W1948902556 modified "2023-10-16" @default.
• W1948902556 title "Identification of Trans-dominant Modifiers of Prat Expression in Drosophila melanogaster" @default.
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• W1948902556 doi "https://doi.org/10.1093/genetics/164.4.1419" @default.
• W1948902556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1462663" @default.
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