Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948907178> ?p ?o ?g. }
- W1948907178 endingPage "72" @default.
- W1948907178 startingPage "366" @default.
- W1948907178 abstract "In Swiss 3T3 fibroblasts, aspirin inhibited proliferation induced by the complete mitogenic factors platelet-derived growth factor (PDGF) and bombesin. Aspirin decreased the maximum mitogenic effect of bombesin without modifying the concentration necessary to obtain half maximal DNA synthesis stimulation. In contrast, aspirin only decreased mitogenesis at subsaturating PDGF concentrations. The effect of aspirin was found to be concentration dependent. The half-maximal effect occurred at approximately 150 microM. The maximal inhibition was obtained when aspirin was added during the first hour after growth factor addition. At this time, both PDGF and bombesin induced prostaglandin E2 synthesis. PDGF induced much higher levels of prostaglandin E2 than bombesin. The inhibitory effects of aspirin on PDGF or bombesin-stimulated DNA synthesis were counteracted by 280 nM prostaglandin E2. Aspirin effects were overcome by agents that increase cellular cyclic adenosine monophosphate levels but not by activation of protein kinase C. The significance of the antiproliferative action of aspirin might be associated with epidemiological data that show a reduced incidence of colorectal and other cancers after aspirin treatment." @default.
- W1948907178 created "2016-06-24" @default.
- W1948907178 creator A5010563579 @default.
- W1948907178 creator A5022041368 @default.
- W1948907178 creator A5048217357 @default.
- W1948907178 creator A5075076955 @default.
- W1948907178 creator A5078326943 @default.
- W1948907178 creator A5091501836 @default.
- W1948907178 date "1997-01-01" @default.
- W1948907178 modified "2023-10-18" @default.
- W1948907178 title "Inhibition of DNA synthesis by aspirin in Swiss 3T3 fibroblasts." @default.
- W1948907178 cites W1485442945 @default.
- W1948907178 cites W1495623459 @default.
- W1948907178 cites W1528340834 @default.
- W1948907178 cites W1539601638 @default.
- W1948907178 cites W1540849804 @default.
- W1948907178 cites W1544616947 @default.
- W1948907178 cites W1548798251 @default.
- W1948907178 cites W1558944421 @default.
- W1948907178 cites W1587929792 @default.
- W1948907178 cites W1856590789 @default.
- W1948907178 cites W1870773788 @default.
- W1948907178 cites W1928411162 @default.
- W1948907178 cites W1974007211 @default.
- W1948907178 cites W1978652207 @default.
- W1948907178 cites W1984274895 @default.
- W1948907178 cites W1987193104 @default.
- W1948907178 cites W1987212025 @default.
- W1948907178 cites W1988939737 @default.
- W1948907178 cites W1992472345 @default.
- W1948907178 cites W2007328223 @default.
- W1948907178 cites W2008574207 @default.
- W1948907178 cites W2010237936 @default.
- W1948907178 cites W2013581100 @default.
- W1948907178 cites W2026307857 @default.
- W1948907178 cites W2026777257 @default.
- W1948907178 cites W2032122995 @default.
- W1948907178 cites W2043707891 @default.
- W1948907178 cites W2048152958 @default.
- W1948907178 cites W2051338926 @default.
- W1948907178 cites W2058486668 @default.
- W1948907178 cites W2059689162 @default.
- W1948907178 cites W2060137414 @default.
- W1948907178 cites W2062108645 @default.
- W1948907178 cites W2118445198 @default.
- W1948907178 cites W2167859431 @default.
- W1948907178 cites W2169682004 @default.
- W1948907178 cites W2273625719 @default.
- W1948907178 cites W2308597410 @default.
- W1948907178 cites W2318925269 @default.
- W1948907178 cites W2323366608 @default.
- W1948907178 cites W2330709704 @default.
- W1948907178 cites W2336215030 @default.
- W1948907178 cites W2409825096 @default.
- W1948907178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8996217" @default.
- W1948907178 hasPublicationYear "1997" @default.
- W1948907178 type Work @default.
- W1948907178 sameAs 1948907178 @default.
- W1948907178 citedByCount "11" @default.
- W1948907178 countsByYear W19489071782013 @default.
- W1948907178 countsByYear W19489071782016 @default.
- W1948907178 crossrefType "journal-article" @default.
- W1948907178 hasAuthorship W1948907178A5010563579 @default.
- W1948907178 hasAuthorship W1948907178A5022041368 @default.
- W1948907178 hasAuthorship W1948907178A5048217357 @default.
- W1948907178 hasAuthorship W1948907178A5075076955 @default.
- W1948907178 hasAuthorship W1948907178A5078326943 @default.
- W1948907178 hasAuthorship W1948907178A5091501836 @default.
- W1948907178 hasConcept C118303440 @default.
- W1948907178 hasConcept C126322002 @default.
- W1948907178 hasConcept C134018914 @default.
- W1948907178 hasConcept C170493617 @default.
- W1948907178 hasConcept C180361614 @default.
- W1948907178 hasConcept C185592680 @default.
- W1948907178 hasConcept C2775960820 @default.
- W1948907178 hasConcept C2777628954 @default.
- W1948907178 hasConcept C2777956040 @default.
- W1948907178 hasConcept C2778448772 @default.
- W1948907178 hasConcept C2780664492 @default.
- W1948907178 hasConcept C2781294074 @default.
- W1948907178 hasConcept C552990157 @default.
- W1948907178 hasConcept C55493867 @default.
- W1948907178 hasConcept C64241487 @default.
- W1948907178 hasConcept C71924100 @default.
- W1948907178 hasConcept C86803240 @default.
- W1948907178 hasConcept C98274493 @default.
- W1948907178 hasConceptScore W1948907178C118303440 @default.
- W1948907178 hasConceptScore W1948907178C126322002 @default.
- W1948907178 hasConceptScore W1948907178C134018914 @default.
- W1948907178 hasConceptScore W1948907178C170493617 @default.
- W1948907178 hasConceptScore W1948907178C180361614 @default.
- W1948907178 hasConceptScore W1948907178C185592680 @default.
- W1948907178 hasConceptScore W1948907178C2775960820 @default.
- W1948907178 hasConceptScore W1948907178C2777628954 @default.
- W1948907178 hasConceptScore W1948907178C2777956040 @default.
- W1948907178 hasConceptScore W1948907178C2778448772 @default.
- W1948907178 hasConceptScore W1948907178C2780664492 @default.
- W1948907178 hasConceptScore W1948907178C2781294074 @default.