FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1948920870> ?p ?o ?g. }

• W1948920870 endingPage "59" @default.
• W1948920870 startingPage "45" @default.
• W1948920870 abstract "Lymph node (LN) metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC) patients. However, in approximately one third of OSCC patients nodal metastases remain undetected, and thus are not adequately treated. Therefore, clinical assessment of LN metastasis needs to be improved. The purpose of this study was to identify DNA methylation biomarkers to predict LN metastases in OSCC. Genome wide methylation assessment was performed on six OSCC with (N+) and six without LN metastases (N0). Differentially methylated sequences were selected based on the likelihood of differential methylation and validated using an independent OSCC cohort as well as OSCC from The Cancer Genome Atlas (TCGA). Expression of WISP1 using immunohistochemistry was analyzed on a large OSCC cohort ( n = 204). MethylCap‐Seq analysis revealed 268 differentially methylated markers. WISP1 was the highest ranking annotated gene that showed hypomethylation in the N+ group. Bisulfite pyrosequencing confirmed significant hypomethylation within the WISP1 promoter region in N+ OSCC ( P = 0.03) and showed an association between WISP1 hypomethylation and high WISP1 expression ( P = 0.01). Both these results were confirmed using 148 OSCC retrieved from the TCGA database. In a large OSCC cohort, high WISP1 expression was associated with LN metastasis ( P = 0.05), disease‐specific survival ( P = 0.022), and regional disease‐free survival ( P = 0.027). These data suggest that WISP1 expression is regulated by methylation and WISP1 hypomethylation contributes to LN metastasis in OSCC. WISP1 is a potential biomarker to predict the presence of LN metastases. © 2015 Wiley Periodicals, Inc." @default.
• W1948920870 created "2016-06-24" @default.
• W1948920870 creator A5001147818 @default.
• W1948920870 creator A5013562070 @default.
• W1948920870 creator A5020771385 @default.
• W1948920870 creator A5024174357 @default.
• W1948920870 creator A5024727242 @default.
• W1948920870 creator A5032634319 @default.
• W1948920870 creator A5043249934 @default.
• W1948920870 creator A5046086242 @default.
• W1948920870 creator A5062094812 @default.
• W1948920870 creator A5065110382 @default.
• W1948920870 creator A5066923315 @default.
• W1948920870 creator A5081512311 @default.
• W1948920870 date "2015-09-22" @default.
• W1948920870 modified "2023-09-27" @default.
• W1948920870 title "Identification and validation of<i>WISP</i><i>1</i>as an epigenetic regulator of metastasis in oral squamous cell carcinoma" @default.
• W1948920870 cites W1495698332 @default.
• W1948920870 cites W1541216017 @default.
• W1948920870 cites W1545254488 @default.
• W1948920870 cites W1568432012 @default.
• W1948920870 cites W1965220537 @default.
• W1948920870 cites W1965262464 @default.
• W1948920870 cites W1968979371 @default.
• W1948920870 cites W1977514824 @default.
• W1948920870 cites W1985362243 @default.
• W1948920870 cites W1987276632 @default.
• W1948920870 cites W1989367702 @default.
• W1948920870 cites W1999560943 @default.
• W1948920870 cites W2000156285 @default.
• W1948920870 cites W2000651976 @default.
• W1948920870 cites W2011006320 @default.
• W1948920870 cites W2013380797 @default.
• W1948920870 cites W2013909504 @default.
• W1948920870 cites W2014039097 @default.
• W1948920870 cites W2014451495 @default.
• W1948920870 cites W2016524159 @default.
• W1948920870 cites W2018469130 @default.
• W1948920870 cites W2020094108 @default.
• W1948920870 cites W2020541351 @default.
• W1948920870 cites W2021459974 @default.
• W1948920870 cites W2024930891 @default.
• W1948920870 cites W2025439263 @default.
• W1948920870 cites W2029377908 @default.
• W1948920870 cites W2039440242 @default.
• W1948920870 cites W2041686632 @default.
• W1948920870 cites W2045788389 @default.
• W1948920870 cites W2052008436 @default.
• W1948920870 cites W2053865773 @default.
• W1948920870 cites W2054131086 @default.
• W1948920870 cites W2056422677 @default.
• W1948920870 cites W2058963315 @default.
• W1948920870 cites W2074746593 @default.
• W1948920870 cites W2076777503 @default.
• W1948920870 cites W2079076888 @default.
• W1948920870 cites W2080553203 @default.
• W1948920870 cites W2081098333 @default.
• W1948920870 cites W2082263250 @default.
• W1948920870 cites W2082998349 @default.
• W1948920870 cites W2085082345 @default.
• W1948920870 cites W2085292382 @default.
• W1948920870 cites W2094628672 @default.
• W1948920870 cites W2099303768 @default.
• W1948920870 cites W2101531342 @default.
• W1948920870 cites W2102120068 @default.
• W1948920870 cites W2106608030 @default.
• W1948920870 cites W2106798509 @default.
• W1948920870 cites W2114843025 @default.
• W1948920870 cites W2118258530 @default.
• W1948920870 cites W2119108115 @default.
• W1948920870 cites W2119594769 @default.
• W1948920870 cites W2124317383 @default.
• W1948920870 cites W2124985265 @default.
• W1948920870 cites W2128016314 @default.
• W1948920870 cites W2132080925 @default.
• W1948920870 cites W2139244902 @default.
• W1948920870 cites W2149441684 @default.
• W1948920870 cites W2153349010 @default.
• W1948920870 cites W2154607830 @default.
• W1948920870 cites W2155718481 @default.
• W1948920870 cites W2157335263 @default.
• W1948920870 cites W2158545941 @default.
• W1948920870 cites W2160697532 @default.
• W1948920870 cites W2166875733 @default.
• W1948920870 cites W2170178908 @default.
• W1948920870 cites W2181426248 @default.
• W1948920870 cites W2328946792 @default.
• W1948920870 cites W2404544934 @default.
• W1948920870 cites W4247554111 @default.
• W1948920870 cites W4321429547 @default.
• W1948920870 doi "https://doi.org/10.1002/gcc.22310" @default.
• W1948920870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26391330" @default.
• W1948920870 hasPublicationYear "2015" @default.
• W1948920870 type Work @default.
• W1948920870 sameAs 1948920870 @default.
• W1948920870 citedByCount "27" @default.
• W1948920870 countsByYear W19489208702016 @default.
• W1948920870 countsByYear W19489208702017 @default.

• next