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- W1948922870 abstract "Effects of tilisolol, a β-adrenoceptor-blocking agent having an ATP-sensitive potassium channel-opening property, on ischaemic myocardial acidosis were studied and compared with those of other β-adrenoceptor-blocking agents.Ischaemia was induced by ligating the left anterior descending coronary artery in anaesthetized dogs. Myocardial pH was measured by a tissue pH monitor. Drugs (tilisolol, 0.2 mg kg−1; propranolol, 1 mg kg−1; amosulalol, 0.3 mg kg−1 and nipradilol, 0.3 mg kg−1) were injected intravenously 5 min before ischaemia. All drugs decreased heart rate. Amosulalol and nipradilol decreased arterial pressure. The myocardial pH in the saline-treated group decreased significantly after 30 min of ischaemia. Each drug attenuated the ischaemiainduced myocardial acidosis. Magnitude of the effects was tilisolol > propranolol > amosulalol ≥ nipradilol. The attenuation of myocardial acidosis with tilisolol was partially abolished by glibenclamide.In conclusion, tilisolol improved the ischaemia-induced myocardial acidosis, and its ATP-sensitive potassium channel-opening action may partially contribute to the pH attenuation." @default.
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- W1948922870 date "1996-07-01" @default.
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- W1948922870 title "Attenuation of Ischaemia‐induced Myocardial Acidosis by Tilisolol, a β‐Adrenoceptor‐blocking Agent with KATP Channel‐opening Activity in Dogs" @default.
- W1948922870 doi "https://doi.org/10.1111/j.2042-7158.1996.tb00619.x" @default.
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