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• W1948934841 endingPage "563" @default.
• W1948934841 startingPage "550" @default.
• W1948934841 abstract "Abstract Axon‐like neuritogenesis in neuroblastoma ( NG 108‐15) cells and primary cerebellar granular neurons is furthered by the presence of ganglioside GM 1. We describe here that galectin‐1 (Gal‐1), a homobivalent endogenous lectin, is an effector by cross‐linking the ganglioside and its associated glycoprotein α 5 β 1 ‐integrin. The thereby triggered signaling cascade involves autophosphorylation of focal adhesion kinase and activation of phospholipase Cγ and phosphoinositide‐3 kinase. This leads to a transient increase in the intracellular Ca 2+ concentration by opening of TRPC 5 channels, which belong to the signal transduction‐gated cation channels. Controls with GM 1‐defective cells ( NG ‐ CR 72 and neurons from ganglio‐series KO mice) were retarded in axonal growth, underscoring the relevance of GM 1 as functional counterreceptor for Gal‐1. The lectin's presence was detected in the NG 108‐15 cells, suggesting an autocrine mechanism of action, and in astrocytes in situ . Gal‐1, as cross‐linking lectin, can thus translate metabolic conversion of ganglioside GD 1a to GM 1 by neuraminidase action into axon growth. image Galectin‐1 (Gal‐1) was shown an effector of axonogenesis in cerebellar granule neurons (CGNs) and NG108‐15 cells by cross‐linking GM1 ganglioside and its associated glycoprotein α 5 β 1 ‐integrin. The resulting signaling led to a transient increase in intracellular Ca 2+ by opening TRPC5 channels. CGNs deficient in GM1 showed retarded axonogenesis, underscoring the relevance of GM1 as functional counterreceptor for Gal‐1 in this process. This Gal‐1/GM1‐induced signaling was manifest only at the earliest, initiating stage of axon development." @default.
• W1948934841 created "2016-06-24" @default.
• W1948934841 creator A5011662659 @default.
• W1948934841 creator A5022208227 @default.
• W1948934841 creator A5027791328 @default.
• W1948934841 creator A5061586215 @default.
• W1948934841 creator A5088038133 @default.
• W1948934841 date "2015-12-28" @default.
• W1948934841 modified "2023-10-03" @default.
• W1948934841 title "Functional interplay between ganglioside<scp>GM</scp>1 and cross‐linking galectin‐1 induces axon‐like neuritogenesis via integrin‐based signaling and<scp>TRPC</scp>5‐dependent Ca²⁺influx" @default.
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• W1948934841 doi "https://doi.org/10.1111/jnc.13418" @default.
• W1948934841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4720552" @default.
• W1948934841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26526326" @default.
• W1948934841 hasPublicationYear "2015" @default.
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