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- W1949016211 endingPage "249" @default.
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- W1949016211 abstract "Alterations in brain structures, including progressive neurodegeneration, are a hallmark in patients with Alzheimer's disease (AD). However, pathological mechanisms, such as the accumulation of amyloid and the proliferation of tau, are thought to begin years, even decades, before the initial clinical manifestations of AD. In this study, we compare the brain anatomy of amnestic mild cognitive impairment patients (aMCI, n = 16) to healthy subjects (CS, n = 22) using cortical thickness, subcortical volume, and shape analysis, which we believe to be complimentary to volumetric measures. We were able to replicate classical cortical thickness alterations in aMCI in the hippocampus, amygdala, putamen, insula, and inferior temporal regions. Additionally, aMCI showed significant thalamic and striatal shape differences. We observed higher global amyloid deposition in aMCI, a significant correlation between striatal displacement and global amyloid, and an inverse correlation between executive function and right-hemispheric thalamic displacement. In contrast, no volumetric differences were detected in thalamic, striatal, and hippocampal regions. Our results provide new evidence for early subcortical neuroanatomical changes in patients with aMCI, which are linked to cognitive abilities and amyloid deposition. Hence, shape analysis may aid in the identification of structural biomarkers for identifying individuals at highest risk of conversion to AD." @default.
- W1949016211 created "2016-06-24" @default.
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- W1949016211 date "2015-11-03" @default.
- W1949016211 modified "2023-10-13" @default.
- W1949016211 title "Volumetric and Shape Analysis of the Thalamus and Striatum in Amnestic Mild Cognitive Impairment" @default.
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- W1949016211 cites W1552768005 @default.
- W1949016211 cites W1558501000 @default.
- W1949016211 cites W1575197904 @default.
- W1949016211 cites W1583887302 @default.
- W1949016211 cites W1632059732 @default.
- W1949016211 cites W1666202957 @default.
- W1949016211 cites W1891773028 @default.
- W1949016211 cites W1914584256 @default.
- W1949016211 cites W1963706902 @default.
- W1949016211 cites W1964962588 @default.
- W1949016211 cites W1966362652 @default.
- W1949016211 cites W1971358295 @default.
- W1949016211 cites W1972438875 @default.
- W1949016211 cites W1980230921 @default.
- W1949016211 cites W1981948185 @default.
- W1949016211 cites W1984424396 @default.
- W1949016211 cites W1985384931 @default.
- W1949016211 cites W1985525810 @default.
- W1949016211 cites W1990725440 @default.
- W1949016211 cites W1991456242 @default.
- W1949016211 cites W1991952617 @default.
- W1949016211 cites W1995195434 @default.
- W1949016211 cites W2004421347 @default.
- W1949016211 cites W2005112198 @default.
- W1949016211 cites W2005972070 @default.
- W1949016211 cites W2008441351 @default.
- W1949016211 cites W2010837501 @default.
- W1949016211 cites W2011424018 @default.
- W1949016211 cites W2012059337 @default.
- W1949016211 cites W2018427609 @default.
- W1949016211 cites W2025894278 @default.
- W1949016211 cites W2025945605 @default.
- W1949016211 cites W2028436804 @default.
- W1949016211 cites W2029262131 @default.
- W1949016211 cites W2037764102 @default.
- W1949016211 cites W2038899746 @default.
- W1949016211 cites W2039664444 @default.
- W1949016211 cites W2039726862 @default.
- W1949016211 cites W2042354961 @default.
- W1949016211 cites W2043379623 @default.
- W1949016211 cites W2045333811 @default.
- W1949016211 cites W2049546272 @default.
- W1949016211 cites W2052226124 @default.
- W1949016211 cites W2055649795 @default.
- W1949016211 cites W2060684078 @default.
- W1949016211 cites W2070368610 @default.
- W1949016211 cites W2071177235 @default.
- W1949016211 cites W2072580777 @default.
- W1949016211 cites W2076133825 @default.
- W1949016211 cites W2077115170 @default.
- W1949016211 cites W2077924486 @default.
- W1949016211 cites W2078096700 @default.
- W1949016211 cites W2090537659 @default.
- W1949016211 cites W2092416940 @default.
- W1949016211 cites W2096937017 @default.
- W1949016211 cites W2098447835 @default.
- W1949016211 cites W2099166256 @default.
- W1949016211 cites W2101598015 @default.
- W1949016211 cites W2110300314 @default.
- W1949016211 cites W2110664827 @default.
- W1949016211 cites W2114624908 @default.
- W1949016211 cites W2120935835 @default.
- W1949016211 cites W2127120806 @default.
- W1949016211 cites W2129497119 @default.
- W1949016211 cites W2129965408 @default.
- W1949016211 cites W2130622075 @default.
- W1949016211 cites W2137730858 @default.
- W1949016211 cites W2154758450 @default.
- W1949016211 cites W2155852925 @default.
- W1949016211 cites W2156533577 @default.
- W1949016211 cites W2162597789 @default.
- W1949016211 cites W2163274894 @default.
- W1949016211 cites W2163958074 @default.
- W1949016211 cites W2165869007 @default.
- W1949016211 doi "https://doi.org/10.3233/jad-150080" @default.
- W1949016211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26444755" @default.
- W1949016211 hasPublicationYear "2015" @default.
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