Matches in SemOpenAlex for { <https://semopenalex.org/work/W1949031330> ?p ?o ?g. }
- W1949031330 abstract "Clinical implications of the MDR1 (ABCB1) multidrug resistance gene polymorphisms) - P Glycoprotein (Pgp), MDR1 (ABCB1) gene product, is an ATP-dependent efflux pump that transports a huge variety of substrates and is a mechanism of protection against xenobiotics. Pgp is involved in the bioavailability of several drugs, affecting their absorption in the gastrointestinal trait and their excretion on kidneys and liver. This protein is also expressed in lungs and in the blood- brain barrier and testis. MDR1 gene presents a great number of polymorphisms and an increasing number of studies shows that some of these may affect Pgp expression and activity. Clinical implications for these polymorphisms have been studied and an influence of these polymorphisms in development and susceptibility of certain diseases were observed. Besides, the relation between MDR1 gene polymorphisms, pharmacological responses and pharmacokinetic profiles for drugs that are Pgp substrates were analyzed. Although several studies try to establish relations between genotypes resulting from MDR1 polymorphisms and clinical aspects, controversies remain. Broader analyses, taking MDR1 haplotypes into account, are necessary to establish the relations between the variability in this gene and the clinical aspects related by Pgp." @default.
- W1949031330 created "2016-06-24" @default.
- W1949031330 creator A5033586587 @default.
- W1949031330 creator A5065709127 @default.
- W1949031330 creator A5083858007 @default.
- W1949031330 date "2006-01-01" @default.
- W1949031330 modified "2023-09-24" @default.
- W1949031330 title "Implicações clínicas dos polimorfismos do gene de resistência a múltiplas drogas MDR1 (ABCB1)" @default.
- W1949031330 cites W123422070 @default.
- W1949031330 cites W1482931358 @default.
- W1949031330 cites W1548348015 @default.
- W1949031330 cites W1565203547 @default.
- W1949031330 cites W1577781821 @default.
- W1949031330 cites W1900016066 @default.
- W1949031330 cites W1912531397 @default.
- W1949031330 cites W1964470226 @default.
- W1949031330 cites W1965128617 @default.
- W1949031330 cites W1968165290 @default.
- W1949031330 cites W1968650353 @default.
- W1949031330 cites W1970218983 @default.
- W1949031330 cites W1972856183 @default.
- W1949031330 cites W1973185796 @default.
- W1949031330 cites W1975261946 @default.
- W1949031330 cites W1977235697 @default.
- W1949031330 cites W1977324053 @default.
- W1949031330 cites W1978096998 @default.
- W1949031330 cites W1981301171 @default.
- W1949031330 cites W1984948258 @default.
- W1949031330 cites W1991886667 @default.
- W1949031330 cites W1995006058 @default.
- W1949031330 cites W1998071425 @default.
- W1949031330 cites W2002345475 @default.
- W1949031330 cites W2002908445 @default.
- W1949031330 cites W2005776262 @default.
- W1949031330 cites W2006434892 @default.
- W1949031330 cites W2008695042 @default.
- W1949031330 cites W2009397108 @default.
- W1949031330 cites W2010442385 @default.
- W1949031330 cites W2013047801 @default.
- W1949031330 cites W2014716332 @default.
- W1949031330 cites W2016380061 @default.
- W1949031330 cites W2017411996 @default.
- W1949031330 cites W2019043185 @default.
- W1949031330 cites W2022793130 @default.
- W1949031330 cites W2022880217 @default.
- W1949031330 cites W2022969736 @default.
- W1949031330 cites W2026103827 @default.
- W1949031330 cites W2026968208 @default.
- W1949031330 cites W2027504487 @default.
- W1949031330 cites W2027860611 @default.
- W1949031330 cites W2028533496 @default.
- W1949031330 cites W2034335509 @default.
- W1949031330 cites W2035206933 @default.
- W1949031330 cites W2035635857 @default.
- W1949031330 cites W2039288367 @default.
- W1949031330 cites W2039667371 @default.
- W1949031330 cites W2040634965 @default.
- W1949031330 cites W2041462138 @default.
- W1949031330 cites W2049268060 @default.
- W1949031330 cites W2050497622 @default.
- W1949031330 cites W2050767064 @default.
- W1949031330 cites W2054458932 @default.
- W1949031330 cites W2059584690 @default.
- W1949031330 cites W2060382789 @default.
- W1949031330 cites W2063288921 @default.
- W1949031330 cites W2065456444 @default.
- W1949031330 cites W2066919313 @default.
- W1949031330 cites W2068537822 @default.
- W1949031330 cites W2077109037 @default.
- W1949031330 cites W2078460877 @default.
- W1949031330 cites W2079308844 @default.
- W1949031330 cites W2080271815 @default.
- W1949031330 cites W2081213990 @default.
- W1949031330 cites W2081761498 @default.
- W1949031330 cites W2086478906 @default.
- W1949031330 cites W2097878215 @default.
- W1949031330 cites W2098938825 @default.
- W1949031330 cites W2108861625 @default.
- W1949031330 cites W2109083028 @default.
- W1949031330 cites W2109380210 @default.
- W1949031330 cites W2110886272 @default.
- W1949031330 cites W2114696695 @default.
- W1949031330 cites W2117944128 @default.
- W1949031330 cites W2118055554 @default.
- W1949031330 cites W2118342649 @default.
- W1949031330 cites W2119468178 @default.
- W1949031330 cites W2120105313 @default.
- W1949031330 cites W2128576944 @default.
- W1949031330 cites W2131584305 @default.
- W1949031330 cites W2138748407 @default.
- W1949031330 cites W2141597037 @default.
- W1949031330 cites W2149552150 @default.
- W1949031330 cites W2150552611 @default.
- W1949031330 cites W2158246924 @default.
- W1949031330 cites W2158924055 @default.
- W1949031330 cites W2163636362 @default.
- W1949031330 cites W2166628294 @default.
- W1949031330 cites W2169984670 @default.
- W1949031330 cites W2170231496 @default.
- W1949031330 cites W2170560435 @default.