FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1949076105> ?p ?o ?g. }

• W1949076105 endingPage "3829" @default.
• W1949076105 startingPage "3820" @default.
• W1949076105 abstract "We hypothesized that quantitative MS/MS-based proteomics at multiple time points, incorporating immunoenrichment prior to rapid microwave and magnetic (IM2) sample preparation, might enable correlation of the relative expression of CD47 and other low abundance proteins to disease progression in the experimental autoimmune encephalomyelitis (EAE) animal model of multiple sclerosis. To test our hypothesis, anti-CD47 antibodies were used to enrich for low abundance CD47 prior to microwave and magnetic proteomics in EAE. Decoding protein expression at each time point, with CD47-immunoenriched samples and targeted proteomic analysis, enabled peptides from the low abundance proteins to be precisely quantified throughout disease progression, including: CD47: 86–99, corresponding to the “marker of self” overexpressed by myelin that prevents phagocytosis, or “cellular devouring,” by microglia and macrophages; myelin basic protein: 223–228, corresponding to myelin basic protein; and migration inhibitory factor: 79–87, corresponding to a proinflammatory cytokine that inhibits macrophage migration. While validation in a larger cohort is underway, we conclude that IM2 proteomics is a rapid method to precisely quantify peptides from CD47 and other low abundance proteins throughout disease progression in EAE. This is likely due to improvements in selectivity and sensitivity, necessary to partially overcome masking of low abundance proteins by high abundance proteins and improve dynamic range." @default.
• W1949076105 created "2016-06-24" @default.
• W1949076105 creator A5003038563 @default.
• W1949076105 creator A5004569714 @default.
• W1949076105 creator A5008482088 @default.
• W1949076105 creator A5019664200 @default.
• W1949076105 creator A5019967924 @default.
• W1949076105 creator A5020026973 @default.
• W1949076105 creator A5024582072 @default.
• W1949076105 creator A5048736871 @default.
• W1949076105 creator A5048784517 @default.
• W1949076105 creator A5050995852 @default.
• W1949076105 creator A5062770635 @default.
• W1949076105 creator A5064294367 @default.
• W1949076105 creator A5081166103 @default.
• W1949076105 date "2012-12-01" @default.
• W1949076105 modified "2023-09-26" @default.
• W1949076105 title "Immunoenrichment microwave and magnetic proteomics for quantifying CD47 in the experimental autoimmune encephalomyelitis model of multiple sclerosis" @default.
• W1949076105 cites W1496122877 @default.
• W1949076105 cites W1547525033 @default.
• W1949076105 cites W1568091560 @default.
• W1949076105 cites W1627206822 @default.
• W1949076105 cites W1970448661 @default.
• W1949076105 cites W1975914956 @default.
• W1949076105 cites W1980789245 @default.
• W1949076105 cites W1989947080 @default.
• W1949076105 cites W2002220495 @default.
• W1949076105 cites W2002764353 @default.
• W1949076105 cites W2004492484 @default.
• W1949076105 cites W2005704383 @default.
• W1949076105 cites W2006595691 @default.
• W1949076105 cites W2010714295 @default.
• W1949076105 cites W2012228419 @default.
• W1949076105 cites W2028390466 @default.
• W1949076105 cites W2039949492 @default.
• W1949076105 cites W2050206640 @default.
• W1949076105 cites W2051581456 @default.
• W1949076105 cites W2054385312 @default.
• W1949076105 cites W2060378908 @default.
• W1949076105 cites W2063299499 @default.
• W1949076105 cites W2066331356 @default.
• W1949076105 cites W2073222193 @default.
• W1949076105 cites W2073239791 @default.
• W1949076105 cites W2084693759 @default.
• W1949076105 cites W2085302913 @default.
• W1949076105 cites W2091455355 @default.
• W1949076105 cites W2101520046 @default.
• W1949076105 cites W2103059117 @default.
• W1949076105 cites W2109759840 @default.
• W1949076105 cites W2109863933 @default.
• W1949076105 cites W2112509710 @default.
• W1949076105 cites W2132259121 @default.
• W1949076105 cites W2133725847 @default.
• W1949076105 cites W2135995285 @default.
• W1949076105 cites W2141638428 @default.
• W1949076105 cites W2143890525 @default.
• W1949076105 cites W2145740810 @default.
• W1949076105 cites W2149845828 @default.
• W1949076105 cites W2152499159 @default.
• W1949076105 cites W2152856916 @default.
• W1949076105 cites W2157830017 @default.
• W1949076105 cites W2158508282 @default.
• W1949076105 cites W4236005129 @default.
• W1949076105 doi "https://doi.org/10.1002/elps.201200515" @default.
• W1949076105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3724470" @default.
• W1949076105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23160929" @default.
• W1949076105 hasPublicationYear "2012" @default.
• W1949076105 type Work @default.
• W1949076105 sameAs 1949076105 @default.
• W1949076105 citedByCount "13" @default.
• W1949076105 countsByYear W19490761052013 @default.
• W1949076105 countsByYear W19490761052014 @default.
• W1949076105 countsByYear W19490761052015 @default.
• W1949076105 countsByYear W19490761052016 @default.
• W1949076105 countsByYear W19490761052017 @default.
• W1949076105 countsByYear W19490761052020 @default.
• W1949076105 countsByYear W19490761052021 @default.
• W1949076105 countsByYear W19490761052022 @default.
• W1949076105 crossrefType "journal-article" @default.
• W1949076105 hasAuthorship W1949076105A5003038563 @default.
• W1949076105 hasAuthorship W1949076105A5004569714 @default.
• W1949076105 hasAuthorship W1949076105A5008482088 @default.
• W1949076105 hasAuthorship W1949076105A5019664200 @default.
• W1949076105 hasAuthorship W1949076105A5019967924 @default.
• W1949076105 hasAuthorship W1949076105A5020026973 @default.
• W1949076105 hasAuthorship W1949076105A5024582072 @default.
• W1949076105 hasAuthorship W1949076105A5048736871 @default.
• W1949076105 hasAuthorship W1949076105A5048784517 @default.
• W1949076105 hasAuthorship W1949076105A5050995852 @default.
• W1949076105 hasAuthorship W1949076105A5062770635 @default.
• W1949076105 hasAuthorship W1949076105A5064294367 @default.
• W1949076105 hasAuthorship W1949076105A5081166103 @default.
• W1949076105 hasBestOaLocation W19490761052 @default.
• W1949076105 hasConcept C104317684 @default.
• W1949076105 hasConcept C104397665 @default.
• W1949076105 hasConcept C169760540 @default.
• W1949076105 hasConcept C185592680 @default.
• W1949076105 hasConcept C203014093 @default.

• next