FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1949077487> ?p ?o ?g. }

• W1949077487 endingPage "111" @default.
• W1949077487 startingPage "105" @default.
• W1949077487 abstract "Abstract The aim of this study was to compare the degree of occupancy of central nicotinic acetylcholine receptors (nAChR) in isoflurane anaesthetized baboon brain following inhalation of tobacco smoke (one cigarette containing 0.9 mg nicotine) or i.v. nicotine (0.6 mg i.v.). [ 18 F]Fluoro‐A‐85380 and positron emission tomography (PET) were used to assess the distribution volumes (DV) of the radiotracer in selected brain areas using a one‐compartment model. Eighty minutes after nicotine i.v., DV was reduced by 50 and 66% in the thalamus and putamen, respectively. Six hours after nicotine, a reduction in DV (27% in the thalamus) was still observed. Eighty minutes after inhalation of tobacco smoke, DV was decreased by 52 and 65% in the thalamus and putamen, respectively. Previous PET experiments have demonstrated a short‐lasting interaction of [ 11 C]nicotine with nAChRs. Thus, we hypothesized that a metabolite of nicotine with high affinity and long half‐live (several hours) could bind at nAChRs. Eighty minutes after a high dose of nornicotine (0.5 mg i.v.), DV was reduced by 53 and 31% in thalamus and putamen, respectively. No significant effect was observed following 0.15 mg nornicotine. Therefore, nornicotine could contribute to the long‐lasting occupancy of central nAChRs after smoking." @default.
• W1949077487 created "2016-06-24" @default.
• W1949077487 creator A5001522381 @default.
• W1949077487 creator A5001864168 @default.
• W1949077487 creator A5016945907 @default.
• W1949077487 creator A5043413534 @default.
• W1949077487 creator A5081023850 @default.
• W1949077487 creator A5083594045 @default.
• W1949077487 date "2002-12-13" @default.
• W1949077487 modified "2023-10-16" @default.
• W1949077487 title "Long-lasting occupancy of central nicotinic acetylcholine receptors after smoking: a PET study in monkeys" @default.
• W1949077487 cites W1991074448 @default.
• W1949077487 cites W2002042298 @default.
• W1949077487 cites W2003586297 @default.
• W1949077487 cites W2008871591 @default.
• W1949077487 cites W2017447724 @default.
• W1949077487 cites W2024579992 @default.
• W1949077487 cites W2032457236 @default.
• W1949077487 cites W2047676092 @default.
• W1949077487 cites W2078025525 @default.
• W1949077487 cites W2085107779 @default.
• W1949077487 cites W2091055192 @default.
• W1949077487 cites W2106688439 @default.
• W1949077487 cites W2178006377 @default.
• W1949077487 cites W51848424 @default.
• W1949077487 cites W2020980860 @default.
• W1949077487 doi "https://doi.org/10.1046/j.1471-4159.2003.01502.x" @default.
• W1949077487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12485406" @default.
• W1949077487 hasPublicationYear "2002" @default.
• W1949077487 type Work @default.
• W1949077487 sameAs 1949077487 @default.
• W1949077487 citedByCount "37" @default.
• W1949077487 countsByYear W19490774872012 @default.
• W1949077487 countsByYear W19490774872014 @default.
• W1949077487 countsByYear W19490774872016 @default.
• W1949077487 countsByYear W19490774872017 @default.
• W1949077487 crossrefType "journal-article" @default.
• W1949077487 hasAuthorship W1949077487A5001522381 @default.
• W1949077487 hasAuthorship W1949077487A5001864168 @default.
• W1949077487 hasAuthorship W1949077487A5016945907 @default.
• W1949077487 hasAuthorship W1949077487A5043413534 @default.
• W1949077487 hasAuthorship W1949077487A5081023850 @default.
• W1949077487 hasAuthorship W1949077487A5083594045 @default.
• W1949077487 hasConcept C126322002 @default.
• W1949077487 hasConcept C134018914 @default.
• W1949077487 hasConcept C169760540 @default.
• W1949077487 hasConcept C170493617 @default.
• W1949077487 hasConcept C185592680 @default.
• W1949077487 hasConcept C188987157 @default.
• W1949077487 hasConcept C22885893 @default.
• W1949077487 hasConcept C2776166849 @default.
• W1949077487 hasConcept C2779246727 @default.
• W1949077487 hasConcept C2779547902 @default.
• W1949077487 hasConcept C2779570518 @default.
• W1949077487 hasConcept C2779714222 @default.
• W1949077487 hasConcept C2780374058 @default.
• W1949077487 hasConcept C2780928369 @default.
• W1949077487 hasConcept C42219234 @default.
• W1949077487 hasConcept C71924100 @default.
• W1949077487 hasConcept C80161118 @default.
• W1949077487 hasConcept C86803240 @default.
• W1949077487 hasConcept C98274493 @default.
• W1949077487 hasConceptScore W1949077487C126322002 @default.
• W1949077487 hasConceptScore W1949077487C134018914 @default.
• W1949077487 hasConceptScore W1949077487C169760540 @default.
• W1949077487 hasConceptScore W1949077487C170493617 @default.
• W1949077487 hasConceptScore W1949077487C185592680 @default.
• W1949077487 hasConceptScore W1949077487C188987157 @default.
• W1949077487 hasConceptScore W1949077487C22885893 @default.
• W1949077487 hasConceptScore W1949077487C2776166849 @default.
• W1949077487 hasConceptScore W1949077487C2779246727 @default.
• W1949077487 hasConceptScore W1949077487C2779547902 @default.
• W1949077487 hasConceptScore W1949077487C2779570518 @default.
• W1949077487 hasConceptScore W1949077487C2779714222 @default.
• W1949077487 hasConceptScore W1949077487C2780374058 @default.
• W1949077487 hasConceptScore W1949077487C2780928369 @default.
• W1949077487 hasConceptScore W1949077487C42219234 @default.
• W1949077487 hasConceptScore W1949077487C71924100 @default.
• W1949077487 hasConceptScore W1949077487C80161118 @default.
• W1949077487 hasConceptScore W1949077487C86803240 @default.
• W1949077487 hasConceptScore W1949077487C98274493 @default.
• W1949077487 hasIssue "1" @default.
• W1949077487 hasLocation W19490774871 @default.
• W1949077487 hasLocation W19490774872 @default.
• W1949077487 hasOpenAccess W1949077487 @default.
• W1949077487 hasPrimaryLocation W19490774871 @default.
• W1949077487 hasRelatedWork W1571144558 @default.
• W1949077487 hasRelatedWork W1998217138 @default.
• W1949077487 hasRelatedWork W2006793420 @default.
• W1949077487 hasRelatedWork W2011833485 @default.
• W1949077487 hasRelatedWork W2052941460 @default.
• W1949077487 hasRelatedWork W2577125086 @default.
• W1949077487 hasRelatedWork W289388518 @default.
• W1949077487 hasRelatedWork W2950067586 @default.
• W1949077487 hasRelatedWork W3172992852 @default.
• W1949077487 hasRelatedWork W180634970 @default.
• W1949077487 hasVolume "84" @default.
• W1949077487 isParatext "false" @default.

• next