Matches in SemOpenAlex for { <https://semopenalex.org/work/W1949206767> ?p ?o ?g. }
- W1949206767 endingPage "1363" @default.
- W1949206767 startingPage "1355" @default.
- W1949206767 abstract "Abstract The suppressive effect of rapamycin on T cells has been extensively studied, but its influence on the function of APC is less clear. The data in this study demonstrated that immunostimulatory activity of B10 (H2b) dendritic cells (DC) exposed to rapamycin (rapa-DC) was markedly suppressed as evidenced by the induction of low proliferative responses and specific CTL activity in allogeneic (C3H, H2k) T cells. Administration of rapa-DC significantly prolonged survival of B10 cardiac allografts in C3H recipients. Treatment with rapamycin did not affect DC expression of MHC class II and costimulatory molecules or IL-12 production. Rapamycin did not inhibit DC NF-κB pathway, however, IL-12 signaling through Janus kinase 2/Stat4 activation was markedly suppressed. Indeed, Stat4−/− DC similarly displayed poor allostimulatory activity. The Stat4 downstream product, IFN-γ, was also inhibited by rapamycin, but DC dysfunction could not solely be attributed to low IFN-γ production as DC deficient in IFN-γ still exhibited vigorous allostimulatory activity. Rapamycin did not affect DC IL-12R expression, but markedly suppressed IL-18Rα and β expression, which may in turn down-regulate DC IL-12 autocrine activation." @default.
- W1949206767 created "2016-06-24" @default.
- W1949206767 creator A5007117355 @default.
- W1949206767 creator A5019059459 @default.
- W1949206767 creator A5035604740 @default.
- W1949206767 creator A5043401047 @default.
- W1949206767 creator A5056475996 @default.
- W1949206767 creator A5062469934 @default.
- W1949206767 creator A5090859164 @default.
- W1949206767 date "2004-02-01" @default.
- W1949206767 modified "2023-10-05" @default.
- W1949206767 title "Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway" @default.
- W1949206767 cites W1505859831 @default.
- W1949206767 cites W1510116615 @default.
- W1949206767 cites W1549471106 @default.
- W1949206767 cites W1562592996 @default.
- W1949206767 cites W1566117376 @default.
- W1949206767 cites W1576070276 @default.
- W1949206767 cites W1586837651 @default.
- W1949206767 cites W1601925808 @default.
- W1949206767 cites W1610653714 @default.
- W1949206767 cites W1638308529 @default.
- W1949206767 cites W1814850137 @default.
- W1949206767 cites W1893411048 @default.
- W1949206767 cites W1941619275 @default.
- W1949206767 cites W1945781955 @default.
- W1949206767 cites W1947284792 @default.
- W1949206767 cites W1958745508 @default.
- W1949206767 cites W1964973658 @default.
- W1949206767 cites W1970506485 @default.
- W1949206767 cites W1978971257 @default.
- W1949206767 cites W1986334556 @default.
- W1949206767 cites W1988050497 @default.
- W1949206767 cites W1991524518 @default.
- W1949206767 cites W2012628280 @default.
- W1949206767 cites W2035680000 @default.
- W1949206767 cites W2036763148 @default.
- W1949206767 cites W2049819186 @default.
- W1949206767 cites W2051705414 @default.
- W1949206767 cites W2062811432 @default.
- W1949206767 cites W2067846827 @default.
- W1949206767 cites W2071282292 @default.
- W1949206767 cites W2074871115 @default.
- W1949206767 cites W2084297901 @default.
- W1949206767 cites W2086715846 @default.
- W1949206767 cites W2094646101 @default.
- W1949206767 cites W2095083502 @default.
- W1949206767 cites W2103885096 @default.
- W1949206767 cites W2106877484 @default.
- W1949206767 cites W2110276942 @default.
- W1949206767 cites W2116641130 @default.
- W1949206767 cites W2131666890 @default.
- W1949206767 cites W2140944306 @default.
- W1949206767 cites W2141575322 @default.
- W1949206767 cites W2152172202 @default.
- W1949206767 cites W2166676682 @default.
- W1949206767 cites W2169436688 @default.
- W1949206767 cites W2171345725 @default.
- W1949206767 cites W2173560213 @default.
- W1949206767 cites W4313342465 @default.
- W1949206767 doi "https://doi.org/10.4049/jimmunol.172.3.1355" @default.
- W1949206767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14734710" @default.
- W1949206767 hasPublicationYear "2004" @default.
- W1949206767 type Work @default.
- W1949206767 sameAs 1949206767 @default.
- W1949206767 citedByCount "47" @default.
- W1949206767 countsByYear W19492067672012 @default.
- W1949206767 countsByYear W19492067672013 @default.
- W1949206767 countsByYear W19492067672014 @default.
- W1949206767 countsByYear W19492067672015 @default.
- W1949206767 countsByYear W19492067672016 @default.
- W1949206767 countsByYear W19492067672017 @default.
- W1949206767 countsByYear W19492067672019 @default.
- W1949206767 countsByYear W19492067672020 @default.
- W1949206767 countsByYear W19492067672021 @default.
- W1949206767 crossrefType "journal-article" @default.
- W1949206767 hasAuthorship W1949206767A5007117355 @default.
- W1949206767 hasAuthorship W1949206767A5019059459 @default.
- W1949206767 hasAuthorship W1949206767A5035604740 @default.
- W1949206767 hasAuthorship W1949206767A5043401047 @default.
- W1949206767 hasAuthorship W1949206767A5056475996 @default.
- W1949206767 hasAuthorship W1949206767A5062469934 @default.
- W1949206767 hasAuthorship W1949206767A5090859164 @default.
- W1949206767 hasBestOaLocation W19492067671 @default.
- W1949206767 hasConcept C147969180 @default.
- W1949206767 hasConcept C167672396 @default.
- W1949206767 hasConcept C185592680 @default.
- W1949206767 hasConcept C203014093 @default.
- W1949206767 hasConcept C2776090121 @default.
- W1949206767 hasConcept C2778170410 @default.
- W1949206767 hasConcept C2778277574 @default.
- W1949206767 hasConcept C2778923194 @default.
- W1949206767 hasConcept C502942594 @default.
- W1949206767 hasConcept C62478195 @default.
- W1949206767 hasConcept C65439459 @default.
- W1949206767 hasConcept C86803240 @default.
- W1949206767 hasConcept C8891405 @default.
- W1949206767 hasConcept C95444343 @default.