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• W1949307585 startingPage "4355" @default.
• W1949307585 abstract "Abstract The interactions between Leishmania parasites and dendritic cells (DCs) are complex and involve paradoxical functions that can stimulate or halt T cell responses, leading to the control of infection or progression of disease. The magnitude and profile of DC activation vary greatly, depending upon the Leishmania species/strains, developmental stages, DC subsets, serum opsonization, and exogenous DC stimuli involved in the study. In general, the uptake of Leishmania parasites alone can trigger relatively weak and transient DC activation; however, the intracellular parasites (amastigotes) are capable of down-modulating LPS/IFN-γ-stimulated DC activation via multiple mechanisms. This review will highlight current data regarding the initial interaction of DC subsets with invading parasites, the alterations of DC signaling pathways and function by amastigotes, and the impact of DC functions on protective immunity and disease pathogenesis. Available information provides insight into the mechanisms by which DCs discriminate between the types of pathogens and regulate appropriate immune responses." @default.
• W1949307585 created "2016-06-24" @default.
• W1949307585 creator A5020114169 @default.
• W1949307585 date "2008-04-01" @default.
• W1949307585 modified "2023-10-17" @default.
• W1949307585 title "Modulation of Dendritic Cell Function by <i>Leishmania</i> Parasites" @default.
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• W1949307585 doi "https://doi.org/10.4049/jimmunol.180.7.4355" @default.
• W1949307585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2639709" @default.
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• W1949307585 hasPublicationYear "2008" @default.
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