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- W1949374310 abstract "A study of the osteolysis associated with transplanted plasma-cell neoplasms of strain BALB/c mice was made. Bones, cleared of flesh by papain digestion, and histologic sections were examined. Osteolysis of cortical bone resulted from the intramedullary growth of neoplastic plasma cells and occurred only when the marrow cavity was filled with these cells. Cortical bone appeared to dissolve from the expanding growth of the neoplasm. The openings through the cortex had smooth edges, and typical “punched-out” lesions were noted in the skeleton. On histologic examination osteoclasts and inflammatory cells were not found in the osteolytic areas. In advanced stages neoplastic plasma cells grew through the openings in the cortex and invaded the periosteum, which caused an osteoplastic reaction. The skeletons of 27 mice with primary plasma-cell neoplasms were also examined but showed no osteolytic lesions. The development of osteolytic lesions varied with the route of injection of the neoplastic cells. Following subcutaneous transplantation, osteolytic lesions developed erratically, and they occurred in high frequency when neoplastic plasma cells from ascites fluid were injected intravenously. Observations on the osteoplastic reaction produced by direct implantation on the periosteum were also made. For comparison, other types of neoplasms were studied. These neoplasms rarely caused osteolytic lesions, but the osteoplastic lesions were similar to those produced by the plasma-cell neoplasms." @default.
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- W1949374310 date "1962-03-01" @default.
- W1949374310 modified "2023-09-27" @default.
- W1949374310 title "Bone Lesions Produced by Transplanted Plasma-Cell Tumors in BALB/c Mice" @default.
- W1949374310 doi "https://doi.org/10.1093/jnci/28.3.649" @default.
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