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- W1949402483 endingPage "1449" @default.
- W1949402483 startingPage "1443" @default.
- W1949402483 abstract "Aging is associated with reduced IL-2 production and T cell proliferation. Vitamin E supplementation, in aged animals and humans, increases cell division and IL-2 production by naive T cells. The immune synapse forms at the site of contact between a T cell and an APC and participates in T cell activation. We evaluated whether vitamin E affects the redistribution of signaling proteins to the immune synapse. Purified CD4(+) T cells, from the spleens of young and old mice, were treated with vitamin E before stimulation with a surrogate APC expressing anti-CD3. Using confocal fluorescent microscopy, we observed that CD4(+) T cells from old mice were significantly less likely to recruit signaling proteins to the immune synapse than cells from young mice. Vitamin E increased the percentage of old CD4(+) T cells capable of forming an effective immune synapse. Similar results were found following in vivo supplementation with vitamin E. When compared with memory cells, naive T cells from aged mice were more defective in immune synapse formation and were more responsive to vitamin E supplementation. These data show, for the first time, that vitamin E significantly improves age-related early T cell signaling events in naive CD4(+) T cells." @default.
- W1949402483 created "2016-06-24" @default.
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- W1949402483 date "2007-01-19" @default.
- W1949402483 modified "2023-09-26" @default.
- W1949402483 title "Age-Associated Decline in Effective Immune Synapse Formation of CD4<sup>+</sup> T Cells Is Reversed by Vitamin E Supplementation" @default.
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- W1949402483 doi "https://doi.org/10.4049/jimmunol.178.3.1443" @default.
- W1949402483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17237392" @default.
- W1949402483 hasPublicationYear "2007" @default.
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