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• W1949411069 abstract "Abstract Background: To investigate pharmacokinetics and potency of antitumor activity of a novel 5‐fluorouracil carrier erythrocyte (RBC‐FU) in mice bearing malignant ascites. Methods: RBC‐FU was synthesized with a hyperosmotic technique. The entrapment efficiency of targeted carrier erythrocytes was determined by reverse dialysis method with high‐performance liquid chromatography (HPLC) for analyzing the quantity of 5‐fluorouracil (5‐FU). After a H22 hepatocarcinoma malignant ascites model was established in Kunming mice, 5‐FU encapsulated by carrier erythrocytes (for Group A) and 5‐FU solution (for Group B) at 20 mg per kg were injected into the peritoneal cavity of the mice, respectively. Blood and ascites samples were collected at different times to detect 5‐FU quantity by HPLC. Body weight and survival time of mice were recorded in Group A, B and the Control Group in which mice were injected with normal saline only. Results: 5‐FU was effectively encapsulated into erythrocytes, with an encapsulating effect as 55 ± 0.50%. In Group A, the maximum concentration (Cmax) and the area under curve (AUC) in peritoneal exudates were significantly higher than those of Group B ( P < 0.05). On the other hand, 5‐FU level in serum was significantly lower than that in peritoneal exudates of Group A and B ( P < 0.05). High drug levels in the abdominal cavity in Group A were maintained longer than those in Group B. Compared with that in Group B and the control, the quantity of malignant ascites in Group A had significant regression and the survival time was prolonged. Conclusion: The hyperosmotic method described here could be suitable for producing this novel RBC‐FU as a liposomal drug of potential value for treating malignant ascites by intraperitoneal administration." @default.
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• W1949411069 date "2010-04-28" @default.
• W1949411069 modified "2023-10-17" @default.
• W1949411069 title "Development of novel 5-fluorouracil carrier erythrocyte with pharmacokinetics and potent antitumor activity in mice bearing malignant ascites" @default.
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• W1949411069 doi "https://doi.org/10.1111/j.1440-1746.2009.06155.x" @default.
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