Matches in SemOpenAlex for { <https://semopenalex.org/work/W1949446280> ?p ?o ?g. }
- W1949446280 endingPage "225" @default.
- W1949446280 startingPage "194" @default.
- W1949446280 abstract "Melatonin is a pleiotropically acting regulator molecule, which influences numerous physiological functions. Its secretion by the pineal gland progressively declines by age. Strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease, various other neurological and stressful conditions, pain, cardiovascular diseases, cases of cancer, endocrine and metabolic disorders, in particular diabetes type 2. The significance of melatonergic signaling is also evident from melatonin receptor polymorphisms associated with several of these pathologies. The article outlines the mutual relationship between circadian oscillators and melatonin secretion, the possibilities for readjustment of rhythms by melatonin and its synthetic analogs, the consequences for circadian rhythm-dependent disorders concerning sleep and mood, and limits of treatment. The necessity of distinguishing between short-acting melatonergic effects, which are successful in sleep initiation and phase adjustments, and attempts of replacement strategies is emphasized. Properties of approved and some investigational melatonergic agonists are compared." @default.
- W1949446280 created "2016-06-24" @default.
- W1949446280 creator A5034115336 @default.
- W1949446280 date "2012-04-01" @default.
- W1949446280 modified "2023-10-03" @default.
- W1949446280 title "Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment." @default.
- W1949446280 cites W105688798 @default.
- W1949446280 cites W120374126 @default.
- W1949446280 cites W127716649 @default.
- W1949446280 cites W1480559618 @default.
- W1949446280 cites W1493568492 @default.
- W1949446280 cites W1493696659 @default.
- W1949446280 cites W1505050831 @default.
- W1949446280 cites W1507330027 @default.
- W1949446280 cites W1514033836 @default.
- W1949446280 cites W1522010279 @default.
- W1949446280 cites W1532372165 @default.
- W1949446280 cites W1538008426 @default.
- W1949446280 cites W1545799210 @default.
- W1949446280 cites W1547702444 @default.
- W1949446280 cites W1554079895 @default.
- W1949446280 cites W1588003045 @default.
- W1949446280 cites W1596045288 @default.
- W1949446280 cites W1599715713 @default.
- W1949446280 cites W1625449562 @default.
- W1949446280 cites W1649820184 @default.
- W1949446280 cites W167559880 @default.
- W1949446280 cites W1775426886 @default.
- W1949446280 cites W1826103850 @default.
- W1949446280 cites W1892886295 @default.
- W1949446280 cites W1905923705 @default.
- W1949446280 cites W1932521829 @default.
- W1949446280 cites W1963711116 @default.
- W1949446280 cites W1964759476 @default.
- W1949446280 cites W1965446708 @default.
- W1949446280 cites W1965532359 @default.
- W1949446280 cites W1966006827 @default.
- W1949446280 cites W1967212159 @default.
- W1949446280 cites W1967831035 @default.
- W1949446280 cites W1969009328 @default.
- W1949446280 cites W1969217265 @default.
- W1949446280 cites W1970075441 @default.
- W1949446280 cites W1970980171 @default.
- W1949446280 cites W1971251923 @default.
- W1949446280 cites W1971322511 @default.
- W1949446280 cites W1972198114 @default.
- W1949446280 cites W1973335333 @default.
- W1949446280 cites W1974325142 @default.
- W1949446280 cites W1976895278 @default.
- W1949446280 cites W1977465608 @default.
- W1949446280 cites W1977592003 @default.
- W1949446280 cites W1977642816 @default.
- W1949446280 cites W1978650811 @default.
- W1949446280 cites W1978696108 @default.
- W1949446280 cites W1978946973 @default.
- W1949446280 cites W1979379797 @default.
- W1949446280 cites W1980426188 @default.
- W1949446280 cites W1980607212 @default.
- W1949446280 cites W1981359936 @default.
- W1949446280 cites W1981452461 @default.
- W1949446280 cites W1981662561 @default.
- W1949446280 cites W1982054620 @default.
- W1949446280 cites W1982329006 @default.
- W1949446280 cites W1982374977 @default.
- W1949446280 cites W1982745084 @default.
- W1949446280 cites W1983606133 @default.
- W1949446280 cites W1984231771 @default.
- W1949446280 cites W1984447177 @default.
- W1949446280 cites W1984796397 @default.
- W1949446280 cites W1985123636 @default.
- W1949446280 cites W1985425060 @default.
- W1949446280 cites W1985501047 @default.
- W1949446280 cites W1986597884 @default.
- W1949446280 cites W1987808660 @default.
- W1949446280 cites W1988934115 @default.
- W1949446280 cites W1989493189 @default.
- W1949446280 cites W1989768080 @default.
- W1949446280 cites W1990154472 @default.
- W1949446280 cites W1990205578 @default.
- W1949446280 cites W1991250134 @default.
- W1949446280 cites W1992051625 @default.
- W1949446280 cites W1992610922 @default.
- W1949446280 cites W1992860227 @default.
- W1949446280 cites W1993990076 @default.
- W1949446280 cites W1994557589 @default.
- W1949446280 cites W1996109727 @default.
- W1949446280 cites W1996904074 @default.
- W1949446280 cites W1997125912 @default.
- W1949446280 cites W1997209597 @default.
- W1949446280 cites W1997463511 @default.
- W1949446280 cites W1998204538 @default.
- W1949446280 cites W1998320088 @default.
- W1949446280 cites W1998537378 @default.
- W1949446280 cites W1999385317 @default.
- W1949446280 cites W1999554401 @default.
- W1949446280 cites W1999593533 @default.
- W1949446280 cites W1999970873 @default.
- W1949446280 cites W2001152429 @default.