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- W1949609672 abstract "Type 1 diabetes (T1D) is an autoimmune disease in which progressive loss of self-tolerance, evidenced by accumulation of auto-antibodies and auto-reactive T cells that recognize diverse self-proteins, leads to immune-mediated destruction of pancreatic beta cells and loss of insulin secretion. In this review, we discuss antigens and epitopes in T1D and the role that post-translational modifications play in circumventing tolerance mechanisms and increasing antigenic diversity. Emerging data suggest that, analogous to other autoimmune diseases such as rheumatoid arthritis and celiac disease, enzymatically modified epitopes are preferentially recognized in T1D. Modifying enzymes such as peptidyl deiminases and tissue transglutaminase are activated in response to beta cell stress, providing a mechanistic link between post-translational modification and interactions with the environment. Although studies of such responses in the at-risk population have been limited, current data suggests that breakdown in tolerance through post-translational modification represents an important checkpoint in the development of T1D." @default.
- W1949609672 created "2016-06-24" @default.
- W1949609672 creator A5064167863 @default.
- W1949609672 creator A5068721162 @default.
- W1949609672 creator A5073087501 @default.
- W1949609672 creator A5078738286 @default.
- W1949609672 creator A5085467690 @default.
- W1949609672 date "2015-09-14" @default.
- W1949609672 modified "2023-09-26" @default.
- W1949609672 title "T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes" @default.
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