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- W1949680089 abstract "Background: Strain, frequency, loading time, and strain rate, among others, determine mechanical parameters in osteogenic loading. We showed a significant osteogenic effect on bone mass (BM) by daily peri-implant loading at 1.600 µε.s−1 after 4 weeks. Purpose: To study the peri-implant osteogenic effect of frequency and strain in the guinea pig tibia by in vivo longitudinal micro-computed tomography (CT) analysis. Material and Methods: One week after implant installation in both hind limb tibiae, one implant was loaded daily for 10′ during 4 weeks, while the other served as control. Frequencies (3, 10, and 30 Hz) and strains varied alike in the three series to keep the strain rate constant at 1.600 µε.s−1. In vivo micro-CT scans were taken of both tibiae: 1 week after implantation but before loading (v1) and after 2 (v2) and 4 weeks (v3) of loading as well as postmortem (pm). BM (BM (%) bone-occupied area fraction) was calculated as well as the difference between test and control sides (delta BM) Results: All implants (n = 78) were clinically stable at 4 weeks. Significant increase in BM was measured between v1 and v2 (p < .0001) and between v1 and v3 (p < .0001). A significant positive effect of loading on delta BM was observed in the distal peri-implant marrow 500 Region of Interest already 2 weeks after loading (p = .01) and was significantly larger (11%) in series 1 compared with series 2 (p = .006) and 3 (p = .016). Conclusions: Within the constraints of constant loading time and strain rate, the effect of early implant loading on the peri-implant bone is strongly dependent on strain and frequency. This cortical bone model has shown to be most sensitive for high force loading at low frequency." @default.
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- W1949680089 date "2011-08-04" @default.
- W1949680089 modified "2023-10-03" @default.
- W1949680089 title "Constant Strain Rate and Peri-Implant Bone Modeling: An In Vivo Longitudinal Micro-CT Analysis" @default.
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- W1949680089 doi "https://doi.org/10.1111/j.1708-8208.2011.00375.x" @default.
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