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• W1949700515 abstract "Despite known deficits in postural control in patients with schizophrenia, this domain has not been investigated in youth at ultra high-risk (UHR) for psychosis. This is particularly relevant as postural control implicates dysfunction in the cerebellum-a region implicated in cognitive dysmetria conceptions of schizophrenia but poorly understood in the prodrome. Here, we extended our understanding of movement abnormalities in UHR individuals to include postural control, and have linked these deficits to both symptom severity and cerebello-cortical network connectivity. UHR and healthy control participants completed an instrumentally based balance task to quantify postural control along with a resting state brain imaging scan to investigate cerebellar networks. We also quantified positive and negative symptom severity with structured clinical interviews. The UHR group showed overall increased postural sway and decreased cerebello-cortical resting state connectivity, relative to controls. The decreased cerebello-cortical connectivity was seen across multiple networks. Postural sway was also correlated with cerebellar connectivity in this population and uniquely positively correlated with the severity of negative symptoms. Finally, symptom severity was also associated with cerebellar connectivity. Together, our results point to a potential deficit in sensory integration as an underlying contributor to the increased postural sway, and provide evidence of cerebellar abnormalities in UHR individuals. These results extend our understanding of the motor abnormalities of UHR individuals beyond striatum-based dyskinesias to include postural control and sensory integration deficits, and implicate the cerebellum as a distinct neural substrate preceding the onset of psychosis. Taken together, our results extend the cognitive dysmetria framework to UHR populations." @default.
• W1949700515 created "2016-06-24" @default.
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• W1949700515 date "2014-01-24" @default.
• W1949700515 modified "2023-10-17" @default.
• W1949700515 title "Cerebellar networks in individuals at ultra high‐risk of psychosis: Impact on postural sway and symptom severity" @default.
• W1949700515 cites W1512522369 @default.
• W1949700515 cites W1971272235 @default.
• W1949700515 cites W1981786093 @default.
• W1949700515 cites W1983183519 @default.
• W1949700515 cites W1984339224 @default.
• W1949700515 cites W1985857849 @default.
• W1949700515 cites W1986472175 @default.
• W1949700515 cites W1986504292 @default.
• W1949700515 cites W1990134753 @default.
• W1949700515 cites W1999992635 @default.
• W1949700515 cites W2000140984 @default.
• W1949700515 cites W2001381028 @default.
• W1949700515 cites W2007729962 @default.
• W1949700515 cites W2008607322 @default.
• W1949700515 cites W2008691235 @default.
• W1949700515 cites W2009494091 @default.
• W1949700515 cites W2012007142 @default.
• W1949700515 cites W2012491957 @default.
• W1949700515 cites W2013609200 @default.
• W1949700515 cites W2014387288 @default.
• W1949700515 cites W2017225572 @default.
• W1949700515 cites W2020044743 @default.
• W1949700515 cites W2021753575 @default.
• W1949700515 cites W2024055668 @default.
• W1949700515 cites W2027070906 @default.
• W1949700515 cites W2036507925 @default.
• W1949700515 cites W2043227707 @default.
• W1949700515 cites W2048335199 @default.
• W1949700515 cites W2049473668 @default.
• W1949700515 cites W2050135526 @default.
• W1949700515 cites W2050281315 @default.
• W1949700515 cites W2050282115 @default.
• W1949700515 cites W2055099454 @default.
• W1949700515 cites W2055443761 @default.
• W1949700515 cites W2060892340 @default.
• W1949700515 cites W2065783221 @default.
• W1949700515 cites W2067456724 @default.
• W1949700515 cites W2072486526 @default.
• W1949700515 cites W2076293560 @default.
• W1949700515 cites W2077286823 @default.
• W1949700515 cites W2079590167 @default.
• W1949700515 cites W2085952282 @default.
• W1949700515 cites W2087880221 @default.
• W1949700515 cites W2103785192 @default.
• W1949700515 cites W2104362654 @default.
• W1949700515 cites W2107183327 @default.
• W1949700515 cites W2107380164 @default.
• W1949700515 cites W2115687188 @default.
• W1949700515 cites W2116643776 @default.
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• W1949700515 cites W2119255235 @default.
• W1949700515 cites W2120546516 @default.
• W1949700515 cites W2122881750 @default.
• W1949700515 cites W2126159475 @default.
• W1949700515 cites W2127679160 @default.
• W1949700515 cites W2132074265 @default.
• W1949700515 cites W2134820284 @default.
• W1949700515 cites W2143947644 @default.
• W1949700515 cites W2146194743 @default.
• W1949700515 cites W2148726987 @default.
• W1949700515 cites W2151094395 @default.
• W1949700515 cites W2153254791 @default.
• W1949700515 cites W2158929255 @default.
• W1949700515 cites W2161247042 @default.
• W1949700515 cites W2171888483 @default.
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• W1949700515 doi "https://doi.org/10.1002/hbm.22458" @default.
• W1949700515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4107098" @default.
• W1949700515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24464473" @default.
• W1949700515 hasPublicationYear "2014" @default.
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