Matches in SemOpenAlex for { <https://semopenalex.org/work/W1949839622> ?p ?o ?g. }
- W1949839622 endingPage "9" @default.
- W1949839622 startingPage "1" @default.
- W1949839622 abstract "Apoptosis has been reported to induce changes in the remodelling of membrane lipids; after death receptor engagement, specific changes of lipid composition occur not only at the plasma membrane, but also in intracellular membranes. This paper focuses on one important aspect of apoptotic changes in cellular lipids, namely, the redistribution of the mitochondria-specific phospholipid, cardiolipin (CL). CL predominantly resides in the inner mitochondrial membrane, even if the rapid remodelling of its acyl chains and the subsequent degradation occur in other membrane organelles. After death receptor stimulation, CL appears to concentrate into mitochondrial raft-like microdomains at contact sites between inner and outer mitochondrial membranes, leading to local oligomerization of proapoptotic proteins, including Bid. Clustering of Bid in CL-enriched contacts sites is interconnected with pathways of CL remodelling that intersect membrane traffic routes dependent upon actin. In addition, CL association with cytoskeleton protein vimentin was observed. Such novel association also indicated that CL molecules may be expressed at the cell surface following apoptotic stimuli. This observation adds a novel implication of biomedical relevance. The association of CL with vimentin at the cell surface may represent a new target antigen in the context of the apoptotic origin of anti-vimentin/CL autoantibodies in Antiphospholipid Syndrome." @default.
- W1949839622 created "2016-06-24" @default.
- W1949839622 creator A5003415888 @default.
- W1949839622 creator A5030335157 @default.
- W1949839622 creator A5047861370 @default.
- W1949839622 creator A5048821169 @default.
- W1949839622 creator A5051561794 @default.
- W1949839622 creator A5060904495 @default.
- W1949839622 creator A5071368565 @default.
- W1949839622 creator A5073735460 @default.
- W1949839622 creator A5078388130 @default.
- W1949839622 date "2015-01-01" @default.
- W1949839622 modified "2023-10-17" @default.
- W1949839622 title "Altered Traffic of Cardiolipin during Apoptosis: Exposure on the Cell Surface as a Trigger for “Antiphospholipid Antibodies”" @default.
- W1949839622 cites W1517340429 @default.
- W1949839622 cites W1528360418 @default.
- W1949839622 cites W1529356803 @default.
- W1949839622 cites W1547132539 @default.
- W1949839622 cites W1554372630 @default.
- W1949839622 cites W1558103114 @default.
- W1949839622 cites W1558932317 @default.
- W1949839622 cites W1565406437 @default.
- W1949839622 cites W1569409978 @default.
- W1949839622 cites W1585414631 @default.
- W1949839622 cites W1594016328 @default.
- W1949839622 cites W1745634660 @default.
- W1949839622 cites W1762647466 @default.
- W1949839622 cites W1815845775 @default.
- W1949839622 cites W1832181040 @default.
- W1949839622 cites W1925799544 @default.
- W1949839622 cites W1940692702 @default.
- W1949839622 cites W1966820455 @default.
- W1949839622 cites W1971186972 @default.
- W1949839622 cites W1972482460 @default.
- W1949839622 cites W1975727111 @default.
- W1949839622 cites W1979126565 @default.
- W1949839622 cites W1979128141 @default.
- W1949839622 cites W1980298403 @default.
- W1949839622 cites W1980792888 @default.
- W1949839622 cites W1981739062 @default.
- W1949839622 cites W1982940971 @default.
- W1949839622 cites W1984943603 @default.
- W1949839622 cites W1997208169 @default.
- W1949839622 cites W1997631819 @default.
- W1949839622 cites W1997807415 @default.
- W1949839622 cites W2002963487 @default.
- W1949839622 cites W2004477493 @default.
- W1949839622 cites W2004693594 @default.
- W1949839622 cites W2008117286 @default.
- W1949839622 cites W2009219626 @default.
- W1949839622 cites W2011692072 @default.
- W1949839622 cites W2012817138 @default.
- W1949839622 cites W2014122625 @default.
- W1949839622 cites W2018624539 @default.
- W1949839622 cites W2020165436 @default.
- W1949839622 cites W2024505421 @default.
- W1949839622 cites W2029386230 @default.
- W1949839622 cites W2033596616 @default.
- W1949839622 cites W2039060799 @default.
- W1949839622 cites W2039445898 @default.
- W1949839622 cites W2041561160 @default.
- W1949839622 cites W2044247344 @default.
- W1949839622 cites W2045727539 @default.
- W1949839622 cites W2045823608 @default.
- W1949839622 cites W2046103197 @default.
- W1949839622 cites W2046838002 @default.
- W1949839622 cites W2048948369 @default.
- W1949839622 cites W2051506906 @default.
- W1949839622 cites W2052853635 @default.
- W1949839622 cites W2052905773 @default.
- W1949839622 cites W2057220797 @default.
- W1949839622 cites W2060245884 @default.
- W1949839622 cites W2060759027 @default.
- W1949839622 cites W2063362926 @default.
- W1949839622 cites W2067795450 @default.
- W1949839622 cites W2068005229 @default.
- W1949839622 cites W2079462709 @default.
- W1949839622 cites W2082261245 @default.
- W1949839622 cites W2089818400 @default.
- W1949839622 cites W2090898691 @default.
- W1949839622 cites W2092032893 @default.
- W1949839622 cites W2092842024 @default.
- W1949839622 cites W2093977796 @default.
- W1949839622 cites W2099103099 @default.
- W1949839622 cites W2105308642 @default.
- W1949839622 cites W2109508815 @default.
- W1949839622 cites W2113891001 @default.
- W1949839622 cites W2121643037 @default.
- W1949839622 cites W2126048177 @default.
- W1949839622 cites W2127910803 @default.
- W1949839622 cites W2128347259 @default.
- W1949839622 cites W2129642410 @default.
- W1949839622 cites W2130714435 @default.
- W1949839622 cites W2131523916 @default.
- W1949839622 cites W2136172467 @default.
- W1949839622 cites W2139547086 @default.
- W1949839622 cites W2140582776 @default.
- W1949839622 cites W2140809983 @default.