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- W1949862095 abstract "Aims We investigated the relationship between IL-1β and morphological and functional changes following partial bladder outlet obstruction (pBOO). Methods Female wild-type C57/BL6 mice (WT) and IL-1β-/- mice (KO) were used. Animals were sacrificed either 1 or 3 weeks after pBOO or sham surgery, and their bladders were harvested to determine bladder weight, for RT-PCR to measure interleukin-1β (IL-1β), insulin growth factor-1 (IGF-1), and transforming growth factor-β (TGF-β) levels, and for histological analysis with Hematoxylin-Eosin (HE) staining. Cystometry was performed on conscious animals 3 weeks after surgery to evaluate urodynamic parameters. IGF-1 was also administered intraperitoneally to KO with pBOO, and bladder weight was then investigated. Results IL-1β-mRNA levels were significantly higher in WT-pBOO than in WT-sham. IGF-1-mRNA and TGF-β-mRNA levels were also significantly higher in WT-pBOO than in WT-sham; however, these increases were smaller in KO-pBOO than in WT-pBOO. Bladder weight was significantly higher in WT-pBOO than in WT-sham, while increases in bladder weight were significantly suppressed in KO-pBOO. HE staining revealed the thickened bladder wall in WT-pBOO, and this phenomenon was less in KO-pBOO than in WT-pBOO. Regarding the urodynamic parameters examined, micturition pressure and bladder capacity were significantly higher in WT-pBOO than in WT-sham, but remained unchanged in KO-pBOO. The administration of IGF-1 to KO-pBOO led to similar increases in bladder weight and the thickened bladder wall as those observed in WT-pBOO. Conclusion IL-1β has the potential to induce bladder remodeling and deteriorate urodynamic parameters in pBOO. Neurourol. Urodynam. 35:377–381, 2016. © 2015 Wiley Periodicals, Inc." @default.
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- W1949862095 date "2015-01-03" @default.
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- W1949862095 title "The inflammatory cytokine IL-1β is involved in bladder remodeling after bladder outlet obstruction in mice" @default.
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- W1949862095 doi "https://doi.org/10.1002/nau.22721" @default.
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