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- W1949953198 abstract "Studies over the last two decades have identified that amplified human epidermal growth factor receptor (HER-2; c-erbB-2, neu) and its overexpression have been frequently implicated in the carcinogenesis and prognosis in a variety of solid tumours, especially breast cancer. Lots of painstaking efforts were invested on the HER-2 targeted agents, and significantly improved outcome and prolonged the survival of patients. However, some patients classified as 'HER-2-positive' would be still resistant to the anti-HER-2 therapy. Various mechanisms of drug resistance have been illustrated and the alteration of HER-2 was considered as a crucial mechanism. However, systematic researches in regard to the HER-2 mutations and variants are still inadequate. Notably, the alterations of HER-2 play an important role in drug resistance, but also have a potential association with the cancer risk. In this review, we summarize the possible mutations and focus on HER-2 variants' role in breast cancer tumourigenesis. Additionally, the alteration of HER-2, as a potential mechanism of resistance to trastuzumab, is discussed here. We hope that HER-2 related activating mutations could potentially offer more therapeutic opportunities to a broader range of patients than previously classified as HER-2 overexpressed." @default.
- W1949953198 created "2016-06-24" @default.
- W1949953198 creator A5003829936 @default.
- W1949953198 creator A5029226781 @default.
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- W1949953198 creator A5056194338 @default.
- W1949953198 creator A5068093752 @default.
- W1949953198 creator A5087447670 @default.
- W1949953198 date "2015-08-25" @default.
- W1949953198 modified "2023-10-14" @default.
- W1949953198 title "Analysis of different <scp>HER</scp>‐2 mutations in breast cancer progression and drug resistance" @default.
- W1949953198 cites W1583886175 @default.
- W1949953198 cites W1893360284 @default.
- W1949953198 cites W1964321121 @default.
- W1949953198 cites W1966598152 @default.
- W1949953198 cites W1967015398 @default.
- W1949953198 cites W1968836535 @default.
- W1949953198 cites W1969380159 @default.
- W1949953198 cites W1974740818 @default.
- W1949953198 cites W1977901251 @default.
- W1949953198 cites W1983936215 @default.
- W1949953198 cites W1984759779 @default.
- W1949953198 cites W1987362747 @default.
- W1949953198 cites W1988373577 @default.
- W1949953198 cites W1990774346 @default.
- W1949953198 cites W1991352603 @default.
- W1949953198 cites W1991905225 @default.
- W1949953198 cites W1995242599 @default.
- W1949953198 cites W1995653405 @default.
- W1949953198 cites W1996778928 @default.
- W1949953198 cites W1998417857 @default.
- W1949953198 cites W2002937040 @default.
- W1949953198 cites W2004049047 @default.
- W1949953198 cites W2004834404 @default.
- W1949953198 cites W2009897234 @default.
- W1949953198 cites W2012732226 @default.
- W1949953198 cites W2013084840 @default.
- W1949953198 cites W2015616444 @default.
- W1949953198 cites W2016884538 @default.
- W1949953198 cites W2017693082 @default.
- W1949953198 cites W2018178643 @default.
- W1949953198 cites W2020228459 @default.
- W1949953198 cites W2022095980 @default.
- W1949953198 cites W2023681515 @default.
- W1949953198 cites W2028415754 @default.
- W1949953198 cites W2029166421 @default.
- W1949953198 cites W2029599129 @default.
- W1949953198 cites W2038081635 @default.
- W1949953198 cites W2040142253 @default.
- W1949953198 cites W2040935952 @default.
- W1949953198 cites W2042174846 @default.
- W1949953198 cites W2042378775 @default.
- W1949953198 cites W2043696829 @default.
- W1949953198 cites W2049449785 @default.
- W1949953198 cites W2053228245 @default.
- W1949953198 cites W2060084543 @default.
- W1949953198 cites W2060563179 @default.
- W1949953198 cites W2063382533 @default.
- W1949953198 cites W2066516593 @default.
- W1949953198 cites W2069526613 @default.
- W1949953198 cites W2074781545 @default.
- W1949953198 cites W2077778212 @default.
- W1949953198 cites W2078454159 @default.
- W1949953198 cites W2079997250 @default.
- W1949953198 cites W2082592896 @default.
- W1949953198 cites W2084993196 @default.
- W1949953198 cites W2085470185 @default.
- W1949953198 cites W2088377329 @default.
- W1949953198 cites W2089071484 @default.
- W1949953198 cites W2090534984 @default.
- W1949953198 cites W2095659509 @default.
- W1949953198 cites W2096628771 @default.
- W1949953198 cites W2100439220 @default.
- W1949953198 cites W2103441967 @default.
- W1949953198 cites W2104728809 @default.
- W1949953198 cites W2107002118 @default.
- W1949953198 cites W2107562400 @default.
- W1949953198 cites W2108187449 @default.
- W1949953198 cites W2112745583 @default.
- W1949953198 cites W2112854176 @default.
- W1949953198 cites W2113868669 @default.
- W1949953198 cites W2116107451 @default.
- W1949953198 cites W2117241186 @default.
- W1949953198 cites W2120365528 @default.
- W1949953198 cites W2123185010 @default.
- W1949953198 cites W2123696077 @default.
- W1949953198 cites W2124869714 @default.
- W1949953198 cites W2127433418 @default.
- W1949953198 cites W2129360604 @default.
- W1949953198 cites W2130479718 @default.
- W1949953198 cites W2133613600 @default.
- W1949953198 cites W2133867160 @default.
- W1949953198 cites W2133952555 @default.
- W1949953198 cites W2135051816 @default.
- W1949953198 cites W2137158968 @default.
- W1949953198 cites W2137776025 @default.
- W1949953198 cites W2141393790 @default.
- W1949953198 cites W2144499620 @default.