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• W1950049235 endingPage "5672" @default.
• W1950049235 startingPage "5662" @default.
• W1950049235 abstract "Foxp3(+) regulatory T cells (Tregs) are crucial for preventing autoimmunity. We have demonstrated that depletion of Foxp3(+) Tregs results in the development of a scurfy-like disease, indicating that Foxp3(-) effector T cells are sufficient to induce autoimmunity. It has been postulated that nonfunctional Tregs carrying potentially self-reactive T cell receptors may contribute to scurfy (sf) pathogenesis due to enhanced recognition of self. Those cells, however, could not be identified in sf mutants due to the lack of Foxp3 protein expression. To address this issue, we crossed the natural sf mouse mutant with bacterial artificial chromosome transgenic DEREG (depletion of regulatory T cells) mice. Since DEREG mice express GFP under the control of an additional Foxp3 promoter, those crossings allowed proving the existence of would-be Tregs, which are characterized by GFP expression in the absence of functional Foxp3. Sf Tregs lost their in vitro suppressive capacity. This correlated with a substantial reduction of intracellular cAMP levels, whereas surface expression of Treg markers was unaffected. Both GFP(+) and GFP(-) sf cells produced high amounts of Th2-type cytokines, reflected also by enhanced Gata-3 expression, when tested in vitro. Nevertheless, sf Tregs could be induced in vitro, although with lower efficiency than DEREG Tregs. Transfer of GFP(+) sf Tregs, in contrast to GFP(-) sf T cells, into RAG1-deficient animals did not cause the sf phenotype. Taken together, natural and induced Tregs develop in the absence of Foxp3 in sf mice, which lack both suppressive activity and autoreactive potential, but rather display a Th2-biased phenotype." @default.
• W1950049235 created "2016-06-24" @default.
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• W1950049235 date "2009-11-01" @default.
• W1950049235 modified "2023-10-01" @default.
• W1950049235 title "Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice" @default.
• W1950049235 cites W1486722793 @default.
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• W1950049235 cites W1575585006 @default.
• W1950049235 cites W1591129987 @default.
• W1950049235 cites W1619186743 @default.
• W1950049235 cites W1780702984 @default.
• W1950049235 cites W1963832008 @default.
• W1950049235 cites W1966073503 @default.
• W1950049235 cites W1966755152 @default.
• W1950049235 cites W1967351618 @default.
• W1950049235 cites W1972187865 @default.
• W1950049235 cites W1975322648 @default.
• W1950049235 cites W1977181138 @default.
• W1950049235 cites W1985406652 @default.
• W1950049235 cites W1987772726 @default.
• W1950049235 cites W1992641327 @default.
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• W1950049235 cites W2002726823 @default.
• W1950049235 cites W2013146483 @default.
• W1950049235 cites W2014540704 @default.
• W1950049235 cites W2021106791 @default.
• W1950049235 cites W2021603971 @default.
• W1950049235 cites W2024263435 @default.
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• W1950049235 cites W2037505364 @default.
• W1950049235 cites W2041659209 @default.
• W1950049235 cites W2041980736 @default.
• W1950049235 cites W2046361773 @default.
• W1950049235 cites W2051947926 @default.
• W1950049235 cites W2052307040 @default.
• W1950049235 cites W2057132697 @default.
• W1950049235 cites W2061071534 @default.
• W1950049235 cites W2062443745 @default.
• W1950049235 cites W2063547594 @default.
• W1950049235 cites W2065434799 @default.
• W1950049235 cites W2067850515 @default.
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• W1950049235 cites W2084560238 @default.
• W1950049235 cites W2087998194 @default.
• W1950049235 cites W2091483766 @default.
• W1950049235 cites W2097811455 @default.
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• W1950049235 cites W2148806075 @default.
• W1950049235 cites W2149915530 @default.
• W1950049235 cites W2159401396 @default.
• W1950049235 cites W2164701887 @default.
• W1950049235 cites W2166432539 @default.
• W1950049235 cites W2168701099 @default.
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• W1950049235 doi "https://doi.org/10.4049/jimmunol.0803762" @default.
• W1950049235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19812199" @default.
• W1950049235 hasPublicationYear "2009" @default.
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