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- W1950151648 abstract "Abstract Aim . We aimed to investigate whether this polymorphism has any effects on the development of the differences in the progression of the OSAS patients. Methods . The patient group was selected from patients admitted to the our Sleep Laboratory. Total 122 subjects, 44 OSAS patients (only), 32 OSAS patients with cardio vascular diseases (CVD) and 46 controls, were enrolled in the study. The control group consisted of healthy volunteers who had no symptoms of OSAS and scored 0 on the Epworth sleepiness scale. In order to determine gene mutations, DNA isolation was performed from peripheral blood samples. Results . While mean weight and BMI were significantly different, no significant differences were found between patient and control groups in terms of FV Leiden allele distributions. Conclusion . FV Leiden mutation does not affect progression in patients with OSAS Keywords : Obstructive sleep apnea, polymorphism, mutation Ozet Amac . Bu calismada OSAS hastalarinin progresyonunda farkliliklar olusmasinda FV Leiden polimorfizminin herhangi bir etkisi olup olmadigini arastirmayi amacladik. Yontem . Hasta grubu uyku laboratuvarimiza basvuran hastalardan secildi. Toplam 122 kisi ( 44 OSAS hastasi (yalnizca), 32 kardiyovaskuler hastaligi (KVH) olan OSAS hastasi ve 46 kontrol grubu) calismamiza katildi. Kontrol grubu OSAS semptomlari bulunmayan, Epworth uykusuzluk skalasi 0 olan saglikli gonululerden olusturuldu. Gen mutasyonlarini belirlemek icin DNA izolasyonu periferik kandan yapildi. Bulgular . BMI ve agirlik ortalamalari onemli oranda farkliyken, FV Leiden allel dagilimlari acisindan hasta ve kontrol gruplari arasinda onemli bir farklilik bulunamadi. Sonuc . FV Leiden mutasyonu OSAS hastalarinda progresyonu etkilememektedir Anahtar sozcukler : Obstruktif uyku apnesi, polimorfizm, mutasyon" @default.
- W1950151648 created "2016-06-24" @default.
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- W1950151648 date "2010-03-11" @default.
- W1950151648 modified "2023-09-27" @default.
- W1950151648 title "The distribution of FV Leiden gene mutation in patients with obstructive sleep apnea" @default.
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- W1950151648 doi "https://doi.org/10.7197/cmj.v32i1.1008000344" @default.
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