Matches in SemOpenAlex for { <https://semopenalex.org/work/W1950215363> ?p ?o ?g. }
- W1950215363 endingPage "232" @default.
- W1950215363 startingPage "225" @default.
- W1950215363 abstract "Abstract Introduction The objective of this study was to investigate serial changes in maternal endothelial function, inflammatory response and uterine artery blood flow in normal pregnancy, and to explore their inter‐relation. Material and methods In this prospective longitudinal observational study, 53 women with uncomplicated pregnancies were examined at 4‐weekly intervals (248 observations) during 22–40 weeks of gestation. Uterine artery blood flow was measured using Doppler ultrasonography. Maternal endothelial function was assessed by flow‐mediated vasodilatation (FMD) of the brachial artery. Circulating endothelial progenitor cells (EPC), defined as CD34 + CD133 + VEGFR2 + cells, were quantified by flow cytometry. Biomarkers of inflammation, such as leptin and high sensitivity C‐reactive protein (hsCRP), were measured in plasma samples. Multilevel modeling was used to investigate gestational‐age‐associated serial changes. Results The EPC increased from 6.5 to 12.3 per million mononuclear cells ( p < 0.01) and FMD decreased from 16.3 to 13.4% ( p = 0.20). Leptin increased from 18 to 22 ng/mL ( p < 0.01), and hsCRP did not change significantly ( p = 0.61). There was no significant association between FMD and EPC ( p = 0.66). FMD was significantly associated with hsCRP ( p = 0.002) and leptin ( p = 0.003), but the EPC were not. Neither FMD nor EPC were significantly associated with uterine artery blood flow. Conclusion Changes in FMD were significantly associated with inflammatory biomarkers, suggesting that the reduced nitric oxide‐dependent vasodilatation in late gestation is related to maternal inflammatory response. As EPC and FMD did not correlate, mechanisms other than mobilization of EPC to repair endothelial damage must be responsible for the gestational‐age‐associated increase in EPC." @default.
- W1950215363 created "2016-06-24" @default.
- W1950215363 creator A5009213414 @default.
- W1950215363 creator A5010868547 @default.
- W1950215363 creator A5029779761 @default.
- W1950215363 creator A5031573563 @default.
- W1950215363 creator A5054277173 @default.
- W1950215363 creator A5072353704 @default.
- W1950215363 creator A5086220996 @default.
- W1950215363 creator A5088563624 @default.
- W1950215363 date "2015-11-17" @default.
- W1950215363 modified "2023-10-01" @default.
- W1950215363 title "A longitudinal study of maternal endothelial function, inflammatory response and uterine artery blood flow during the second half of pregnancy" @default.
- W1950215363 cites W1969238978 @default.
- W1950215363 cites W1972936493 @default.
- W1950215363 cites W1973905104 @default.
- W1950215363 cites W1975714739 @default.
- W1950215363 cites W1982651263 @default.
- W1950215363 cites W2006500680 @default.
- W1950215363 cites W2021943936 @default.
- W1950215363 cites W2027435767 @default.
- W1950215363 cites W2027555247 @default.
- W1950215363 cites W2028731789 @default.
- W1950215363 cites W2035483520 @default.
- W1950215363 cites W2041091841 @default.
- W1950215363 cites W2049734945 @default.
- W1950215363 cites W2058643935 @default.
- W1950215363 cites W2063506869 @default.
- W1950215363 cites W2067034277 @default.
- W1950215363 cites W2070822466 @default.
- W1950215363 cites W2082909250 @default.
- W1950215363 cites W2085610664 @default.
- W1950215363 cites W2093866009 @default.
- W1950215363 cites W2104549321 @default.
- W1950215363 cites W2105887865 @default.
- W1950215363 cites W2114952482 @default.
- W1950215363 cites W2154024855 @default.
- W1950215363 cites W2163843680 @default.
- W1950215363 cites W2318372489 @default.
- W1950215363 cites W3023623894 @default.
- W1950215363 cites W4211051919 @default.
- W1950215363 cites W4231232996 @default.
- W1950215363 doi "https://doi.org/10.1111/aogs.12802" @default.
- W1950215363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26462064" @default.
- W1950215363 hasPublicationYear "2015" @default.
- W1950215363 type Work @default.
- W1950215363 sameAs 1950215363 @default.
- W1950215363 citedByCount "20" @default.
- W1950215363 countsByYear W19502153632017 @default.
- W1950215363 countsByYear W19502153632018 @default.
- W1950215363 countsByYear W19502153632019 @default.
- W1950215363 countsByYear W19502153632020 @default.
- W1950215363 countsByYear W19502153632021 @default.
- W1950215363 countsByYear W19502153632023 @default.
- W1950215363 crossrefType "journal-article" @default.
- W1950215363 hasAuthorship W1950215363A5009213414 @default.
- W1950215363 hasAuthorship W1950215363A5010868547 @default.
- W1950215363 hasAuthorship W1950215363A5029779761 @default.
- W1950215363 hasAuthorship W1950215363A5031573563 @default.
- W1950215363 hasAuthorship W1950215363A5054277173 @default.
- W1950215363 hasAuthorship W1950215363A5072353704 @default.
- W1950215363 hasAuthorship W1950215363A5086220996 @default.
- W1950215363 hasAuthorship W1950215363A5088563624 @default.
- W1950215363 hasBestOaLocation W19502153631 @default.
- W1950215363 hasConcept C120770815 @default.
- W1950215363 hasConcept C126322002 @default.
- W1950215363 hasConcept C134018914 @default.
- W1950215363 hasConcept C158846371 @default.
- W1950215363 hasConcept C172680121 @default.
- W1950215363 hasConcept C2776820930 @default.
- W1950215363 hasConcept C2776953305 @default.
- W1950215363 hasConcept C2776992346 @default.
- W1950215363 hasConcept C2777604165 @default.
- W1950215363 hasConcept C2779234561 @default.
- W1950215363 hasConcept C2780613262 @default.
- W1950215363 hasConcept C2780771523 @default.
- W1950215363 hasConcept C2780972559 @default.
- W1950215363 hasConcept C2781207646 @default.
- W1950215363 hasConcept C46973012 @default.
- W1950215363 hasConcept C511355011 @default.
- W1950215363 hasConcept C54355233 @default.
- W1950215363 hasConcept C71924100 @default.
- W1950215363 hasConcept C84393581 @default.
- W1950215363 hasConcept C86803240 @default.
- W1950215363 hasConceptScore W1950215363C120770815 @default.
- W1950215363 hasConceptScore W1950215363C126322002 @default.
- W1950215363 hasConceptScore W1950215363C134018914 @default.
- W1950215363 hasConceptScore W1950215363C158846371 @default.
- W1950215363 hasConceptScore W1950215363C172680121 @default.
- W1950215363 hasConceptScore W1950215363C2776820930 @default.
- W1950215363 hasConceptScore W1950215363C2776953305 @default.
- W1950215363 hasConceptScore W1950215363C2776992346 @default.
- W1950215363 hasConceptScore W1950215363C2777604165 @default.
- W1950215363 hasConceptScore W1950215363C2779234561 @default.
- W1950215363 hasConceptScore W1950215363C2780613262 @default.
- W1950215363 hasConceptScore W1950215363C2780771523 @default.
- W1950215363 hasConceptScore W1950215363C2780972559 @default.
- W1950215363 hasConceptScore W1950215363C2781207646 @default.