Matches in SemOpenAlex for { <https://semopenalex.org/work/W195034981> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W195034981 endingPage "H1945" @default.
- W195034981 startingPage "H1939" @default.
- W195034981 abstract "The dynamic pressure-flow relationship in the canine hindlimb at normal arterial pressure is best explained by modeling a Starling resistor (critical pressure, Pcrit) at the level of the arterioles. Regulation of flow can therefore occur at the Starling resistor through changes in Pcrit or along the length of the vessel through changes in arterial resistance (Ra). We hypothesized that increasing perfusion pressure (Pper) would increase Pcrit due to the myogenic response but would decrease Ra because of flow-mediated vasodilation and passive effects. We pump-perfused vascularly isolated hindlimbs of anesthetized dogs and then measured Pcrit and calculated Ra over Pper range of 75-175 mmHg. When Pper was increased from 75 to 175 mmHg, Pcrit increased from 33 +/- 2 to 48 +/- 6 (means +/- SE) mmHg, whereas Ra decreased from 10.1 +/- 1.2 to 7.86 +/- 0.7 mmHg.min.100 g.ml-1 (P < 0.01). Thus the responses of Pcrit and Ra to an increase in Pper were dissociated. In a second part of the study, we lowered carotid sinus pressure to determine the effects of central factors on local autoregulation. A decrease in carotid sinus pressure increased Pcrit and Ra at each Pper (P < 0.05). We conclude that an increase in Pper causes the arterial vasculature to constrict at the level of the Starling resistor and dilate more proximally. The carotid baroreflex causes an increase in tone throughout the arterial vasculature but does not alter the local response to increases in Pper." @default.
- W195034981 created "2016-06-24" @default.
- W195034981 creator A5034465718 @default.
- W195034981 creator A5067913120 @default.
- W195034981 date "1993-12-01" @default.
- W195034981 modified "2023-10-16" @default.
- W195034981 title "Response of arterial resistance and critical pressure to changes in perfusion pressure in canine hindlimb" @default.
- W195034981 doi "https://doi.org/10.1152/ajpheart.1993.265.6.h1939" @default.
- W195034981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8285232" @default.
- W195034981 hasPublicationYear "1993" @default.
- W195034981 type Work @default.
- W195034981 sameAs 195034981 @default.
- W195034981 citedByCount "7" @default.
- W195034981 countsByYear W1950349812012 @default.
- W195034981 countsByYear W1950349812018 @default.
- W195034981 countsByYear W1950349812023 @default.
- W195034981 crossrefType "journal-article" @default.
- W195034981 hasAuthorship W195034981A5034465718 @default.
- W195034981 hasAuthorship W195034981A5067913120 @default.
- W195034981 hasConcept C111774379 @default.
- W195034981 hasConcept C120770815 @default.
- W195034981 hasConcept C126322002 @default.
- W195034981 hasConcept C146957229 @default.
- W195034981 hasConcept C164705383 @default.
- W195034981 hasConcept C2778774071 @default.
- W195034981 hasConcept C51738704 @default.
- W195034981 hasConcept C71924100 @default.
- W195034981 hasConcept C84393581 @default.
- W195034981 hasConceptScore W195034981C111774379 @default.
- W195034981 hasConceptScore W195034981C120770815 @default.
- W195034981 hasConceptScore W195034981C126322002 @default.
- W195034981 hasConceptScore W195034981C146957229 @default.
- W195034981 hasConceptScore W195034981C164705383 @default.
- W195034981 hasConceptScore W195034981C2778774071 @default.
- W195034981 hasConceptScore W195034981C51738704 @default.
- W195034981 hasConceptScore W195034981C71924100 @default.
- W195034981 hasConceptScore W195034981C84393581 @default.
- W195034981 hasIssue "6" @default.
- W195034981 hasLocation W1950349811 @default.
- W195034981 hasLocation W1950349812 @default.
- W195034981 hasOpenAccess W195034981 @default.
- W195034981 hasPrimaryLocation W1950349811 @default.
- W195034981 hasRelatedWork W1984842434 @default.
- W195034981 hasRelatedWork W1990304727 @default.
- W195034981 hasRelatedWork W2004014618 @default.
- W195034981 hasRelatedWork W2007407129 @default.
- W195034981 hasRelatedWork W2066987101 @default.
- W195034981 hasRelatedWork W2074279218 @default.
- W195034981 hasRelatedWork W2197079962 @default.
- W195034981 hasRelatedWork W2370370239 @default.
- W195034981 hasRelatedWork W2404787761 @default.
- W195034981 hasRelatedWork W2415076883 @default.
- W195034981 hasVolume "265" @default.
- W195034981 isParatext "false" @default.
- W195034981 isRetracted "false" @default.
- W195034981 magId "195034981" @default.
- W195034981 workType "article" @default.