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- W1950399079 abstract "ABSTRACT Sequential Candida glabrata isolates were obtained from the mouth of a patient infected with human immunodeficiency virus type 1 who was receiving high doses of fluconazole for oropharyngeal thrush. Fluconazole-susceptible colonies were replaced by resistant colonies that exhibited both increased fluconazole efflux and increased transcripts of a gene which codes for a protein with 72.5% identity to Pdr5p, an ABC multidrug transporter in Saccharomyces cerevisiae . The deduced protein had a molecular mass of 175 kDa and was composed of two homologous halves, each with six putative transmembrane domains and highly conserved sequences of ATP-binding domains. When the earliest and most azole-susceptible isolate of C. glabrata from this patient was exposed to fluconazole, increased transcripts of the PDR5 homolog appeared, linking azole exposure to regulation of this gene." @default.
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- W1950399079 date "1998-07-01" @default.
- W1950399079 modified "2023-10-04" @default.
- W1950399079 title "Fluconazole Resistance Associated with Drug Efflux and Increased Transcription of a Drug Transporter Gene, <i>PDH1</i> , in <i>Candida glabrata</i>" @default.
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- W1950399079 doi "https://doi.org/10.1128/aac.42.7.1695" @default.
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