Matches in SemOpenAlex for { <https://semopenalex.org/work/W1950434531> ?p ?o ?g. }
- W1950434531 endingPage "35457" @default.
- W1950434531 startingPage "35443" @default.
- W1950434531 abstract "Both wild-type and mutated beta-amyloid (Aβ) peptides can elicit an immune response when delivered subcutaneously. However, only mutated forms of Aβ can sensitize dendritic cells when administered intravenously or intraperitoneally. To understand the role of mutation and delivery routes in creating immune responses, and the function of dendritic cells as therapeutic agents, we used fluorescent-conjugated WT Aβ1-40 (WT40) and artificially mutated Aβ1-40 (22W40) peptides to treat dendritic and Langerhans cells from young and/or old mice at different time points. The cell types were analyzed by flow cytometry and confocal microscopy to identify differences in function and antigen presentation, and Luminex and Western blots for cell activation and associated mechanisms. Our results demonstrated that the artificial mutant, 22W40, enhanced dendritic cell's phagocytosis and antigen presentation better than the WT40. Interestingly, Langerhans cells were more effective at early presentation. The artificial mutant 22W40 increased CD8α+ dendritic cells, CD8+ T-cells, and IFN-γ production when co-cultured with self-lymphocytes and dendritic cells from aged mice (30-month-old). Here, the 22W40 mutant peptide has been found to be potent enough to activate DCs, and that dendritic cell-based therapy may be a more effective treatment for age-related diseases, such as Alzheimer's disease (AD)." @default.
- W1950434531 created "2016-06-24" @default.
- W1950434531 creator A5002049192 @default.
- W1950434531 creator A5008171524 @default.
- W1950434531 creator A5009622189 @default.
- W1950434531 creator A5020284647 @default.
- W1950434531 creator A5031961106 @default.
- W1950434531 creator A5037612071 @default.
- W1950434531 creator A5051756613 @default.
- W1950434531 creator A5054451714 @default.
- W1950434531 creator A5060699815 @default.
- W1950434531 creator A5073101602 @default.
- W1950434531 date "2015-10-14" @default.
- W1950434531 modified "2023-10-15" @default.
- W1950434531 title "Dendritic and Langerhans cells respond to Aβ peptides differently: implication for AD immunotherapy" @default.
- W1950434531 cites W1507104124 @default.
- W1950434531 cites W1547585495 @default.
- W1950434531 cites W1575000707 @default.
- W1950434531 cites W1588685142 @default.
- W1950434531 cites W1592713384 @default.
- W1950434531 cites W1621971853 @default.
- W1950434531 cites W1653912017 @default.
- W1950434531 cites W1769686661 @default.
- W1950434531 cites W1784744653 @default.
- W1950434531 cites W1834424895 @default.
- W1950434531 cites W1909502264 @default.
- W1950434531 cites W1965520385 @default.
- W1950434531 cites W1975365037 @default.
- W1950434531 cites W1983865214 @default.
- W1950434531 cites W1992787595 @default.
- W1950434531 cites W1995089933 @default.
- W1950434531 cites W1997460269 @default.
- W1950434531 cites W2012796473 @default.
- W1950434531 cites W2014344489 @default.
- W1950434531 cites W2021746954 @default.
- W1950434531 cites W2028098121 @default.
- W1950434531 cites W2035202576 @default.
- W1950434531 cites W2040872965 @default.
- W1950434531 cites W2041176483 @default.
- W1950434531 cites W2041200841 @default.
- W1950434531 cites W2047961820 @default.
- W1950434531 cites W2048577975 @default.
- W1950434531 cites W2049404848 @default.
- W1950434531 cites W2051559087 @default.
- W1950434531 cites W2063272219 @default.
- W1950434531 cites W2066013154 @default.
- W1950434531 cites W2069350334 @default.
- W1950434531 cites W2070837551 @default.
- W1950434531 cites W2072237144 @default.
- W1950434531 cites W2081124007 @default.
- W1950434531 cites W2081990092 @default.
- W1950434531 cites W2085368828 @default.
- W1950434531 cites W2089244708 @default.
- W1950434531 cites W2095069717 @default.
- W1950434531 cites W2108629610 @default.
- W1950434531 cites W2110217483 @default.
- W1950434531 cites W2111220263 @default.
- W1950434531 cites W2123676976 @default.
- W1950434531 cites W2126043466 @default.
- W1950434531 cites W2150897631 @default.
- W1950434531 cites W2157739119 @default.
- W1950434531 cites W2170241219 @default.
- W1950434531 cites W4211138961 @default.
- W1950434531 doi "https://doi.org/10.18632/oncotarget.6123" @default.
- W1950434531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4742117" @default.
- W1950434531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26473448" @default.
- W1950434531 hasPublicationYear "2015" @default.
- W1950434531 type Work @default.
- W1950434531 sameAs 1950434531 @default.
- W1950434531 citedByCount "3" @default.
- W1950434531 countsByYear W19504345312020 @default.
- W1950434531 countsByYear W19504345312021 @default.
- W1950434531 countsByYear W19504345312022 @default.
- W1950434531 crossrefType "journal-article" @default.
- W1950434531 hasAuthorship W1950434531A5002049192 @default.
- W1950434531 hasAuthorship W1950434531A5008171524 @default.
- W1950434531 hasAuthorship W1950434531A5009622189 @default.
- W1950434531 hasAuthorship W1950434531A5020284647 @default.
- W1950434531 hasAuthorship W1950434531A5031961106 @default.
- W1950434531 hasAuthorship W1950434531A5037612071 @default.
- W1950434531 hasAuthorship W1950434531A5051756613 @default.
- W1950434531 hasAuthorship W1950434531A5054451714 @default.
- W1950434531 hasAuthorship W1950434531A5060699815 @default.
- W1950434531 hasAuthorship W1950434531A5073101602 @default.
- W1950434531 hasBestOaLocation W19504345311 @default.
- W1950434531 hasConcept C147483822 @default.
- W1950434531 hasConcept C154317977 @default.
- W1950434531 hasConcept C167672396 @default.
- W1950434531 hasConcept C202751555 @default.
- W1950434531 hasConcept C203014093 @default.
- W1950434531 hasConcept C2776090121 @default.
- W1950434531 hasConcept C2777701055 @default.
- W1950434531 hasConcept C2778170410 @default.
- W1950434531 hasConcept C2778973524 @default.
- W1950434531 hasConcept C3753494 @default.
- W1950434531 hasConcept C553184892 @default.
- W1950434531 hasConcept C55493867 @default.
- W1950434531 hasConcept C67662055 @default.