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- W1950444116 abstract "Background: Functional exercise capacity can be assessed by the cycle endurance test (CET) and six-minute walk test (6MWT) in COPD. We sought to investigate the determinants of functional exercise performance of the CET and 6MWT in a large clinical cohort of COPD patients. Methods: A dataset of 2053 COPD patients (43% female, age: 66.9±9.5 years, FEV1: 48.2±23.2 %predicted) was analyzed retrospectively. Patients underwent assessment of respiratory function; medical tests and questionnaires, one maximal incremental cycle test where peak work rate was determined and two functional exercise tests: a CET at 75% of peak work rate and 6MWT. A stepwise multiple linear regression was used to assess determinants. Results: On average, patients had impaired exercise capacity (peak work rate: 56±27 % predicted, 6MWT: 69±17 % predicted). Only 51 (2.5%) of the patients achieved 20min CET time of duration (CET-Tend). The percent of predicted peak work rate achieved differed significantly between men (48±21 %predicted) and women (67±31 %predicted). In contrast, CET-Tend was longer in men (286±174s vs 250±153s, p<0.001). Also, six minute walking distance (6MWD) was higher in men compared to women, both in absolute terms as in percent of predicted (443m, 67%predicted vs 431m, 72%predicted, p<0.05). Gender was associated with the CET-Tend but BMI, FEV1 and FRC were related to the 6MWD highlighting the different determinants of exercise performance between CET and 6MWT. Conclusions: CET-Tend is a valuable outcome of CET as it is related to multiple clinical aspects of disease severity in COPD. Gender difference should temper the interpretation of CET." @default.
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- W1950444116 date "2014-09-01" @default.
- W1950444116 modified "2023-09-22" @default.
- W1950444116 title "Performance of cycle ergometry at 75% of peak work rate by patients with chronic obstructive pulmonary disease: Appropriateness and gender differences" @default.
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