FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1950507937> ?p ?o ?g. }

• W1950507937 endingPage "1470" @default.
• W1950507937 startingPage "1463" @default.
• W1950507937 abstract "Abstract Hapten-induced contact hypersensitivity (CHS) in the skin is a delayed type cellular immune response that can be mediated by CD8+ T cells that produce IFN-γ or IL-17. However, mechanisms for these cytokines in the elicitation of CHS remain to be fully elucidated. In this study, we show that adoptive transfer of CHS with hapten-primed wild-type (WT) CD8+ T cells is reduced in IFN-γR−/− or IL-17R−/− mice compared with WT controls. The infiltration of granulocytes and macrophages in the hapten challenged skin of IL-17R−/− recipients is significantly reduced whereas it is less affected in IFN-γR−/− recipients although CD8+ T cell infiltration is inhibited in both recipients. In contrast, the activity of reactive oxidative species is significantly inhibited in IFN-γR−/− but is less affected in IL-17R−/− recipients. Further analysis reveals that the expression of chemokines and cytokines is differentially regulated in the hapten-challenged skin of IFN-γR−/− or IL-17R−/− recipients compared with WT controls. Interestingly, injection of rIL-17 in the skin induces inflammation with a high level of leukocyte infiltration whereas injection of IFN-γ induces inflammation with a high level of reactive oxidative species. Moreover, neutralization of IL-17 in IFN-γR−/− or IFN-γ in IL-17R−/− mice further suppresses the adoptive transfer of CHS by hapten-primed WT CD8+ T cells. The study demonstrates that IFN-γ and IL-17 mediate the elicitation of CHS by different mechanisms and that both cytokines are required for optimal responses. This outcome improves understanding of pathogenesis and provides new insights into therapeutic strategies for CHS." @default.
• W1950507937 created "2016-06-24" @default.
• W1950507937 creator A5051982352 @default.
• W1950507937 creator A5054934683 @default.
• W1950507937 creator A5055174666 @default.
• W1950507937 creator A5068026217 @default.
• W1950507937 creator A5080885941 @default.
• W1950507937 creator A5084926794 @default.
• W1950507937 date "2009-07-15" @default.
• W1950507937 modified "2023-10-17" @default.
• W1950507937 title "IL-17 and IFN-γ Mediate the Elicitation of Contact Hypersensitivity Responses by Different Mechanisms and Both Are Required for Optimal Responses" @default.
• W1950507937 cites W1504688406 @default.
• W1950507937 cites W1524870232 @default.
• W1950507937 cites W1536099164 @default.
• W1950507937 cites W1575677939 @default.
• W1950507937 cites W1605861898 @default.
• W1950507937 cites W1695995011 @default.
• W1950507937 cites W1912634928 @default.
• W1950507937 cites W1935309503 @default.
• W1950507937 cites W1967547992 @default.
• W1950507937 cites W1972017761 @default.
• W1950507937 cites W1986943437 @default.
• W1950507937 cites W1988899224 @default.
• W1950507937 cites W1991484350 @default.
• W1950507937 cites W1993328396 @default.
• W1950507937 cites W2000086986 @default.
• W1950507937 cites W2006249161 @default.
• W1950507937 cites W2006375257 @default.
• W1950507937 cites W2007035944 @default.
• W1950507937 cites W2008924149 @default.
• W1950507937 cites W2010739993 @default.
• W1950507937 cites W2017046428 @default.
• W1950507937 cites W2020548971 @default.
• W1950507937 cites W2028772793 @default.
• W1950507937 cites W2052313621 @default.
• W1950507937 cites W2055522050 @default.
• W1950507937 cites W2060527543 @default.
• W1950507937 cites W2068871282 @default.
• W1950507937 cites W2073761101 @default.
• W1950507937 cites W2077361460 @default.
• W1950507937 cites W2082816999 @default.
• W1950507937 cites W2086970232 @default.
• W1950507937 cites W2086987955 @default.
• W1950507937 cites W2104167354 @default.
• W1950507937 cites W2105410310 @default.
• W1950507937 cites W2106471879 @default.
• W1950507937 cites W2116537360 @default.
• W1950507937 cites W2116658756 @default.
• W1950507937 cites W2122386753 @default.
• W1950507937 cites W2122940411 @default.
• W1950507937 cites W2124116262 @default.
• W1950507937 cites W2133513836 @default.
• W1950507937 cites W2153983398 @default.
• W1950507937 cites W2156451877 @default.
• W1950507937 cites W2160883911 @default.
• W1950507937 cites W2161552560 @default.
• W1950507937 cites W2163194429 @default.
• W1950507937 cites W2167017590 @default.
• W1950507937 cites W2170010130 @default.
• W1950507937 cites W2171571685 @default.
• W1950507937 cites W2172466148 @default.
• W1950507937 cites W2251794980 @default.
• W1950507937 cites W4243086188 @default.
• W1950507937 cites W4313331748 @default.
• W1950507937 doi "https://doi.org/10.4049/jimmunol.0804108" @default.
• W1950507937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3179907" @default.
• W1950507937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19553527" @default.
• W1950507937 hasPublicationYear "2009" @default.
• W1950507937 type Work @default.
• W1950507937 sameAs 1950507937 @default.
• W1950507937 citedByCount "99" @default.
• W1950507937 countsByYear W19505079372012 @default.
• W1950507937 countsByYear W19505079372013 @default.
• W1950507937 countsByYear W19505079372014 @default.
• W1950507937 countsByYear W19505079372015 @default.
• W1950507937 countsByYear W19505079372016 @default.
• W1950507937 countsByYear W19505079372017 @default.
• W1950507937 countsByYear W19505079372018 @default.
• W1950507937 countsByYear W19505079372019 @default.
• W1950507937 countsByYear W19505079372020 @default.
• W1950507937 countsByYear W19505079372021 @default.
• W1950507937 countsByYear W19505079372022 @default.
• W1950507937 countsByYear W19505079372023 @default.
• W1950507937 crossrefType "journal-article" @default.
• W1950507937 hasAuthorship W1950507937A5051982352 @default.
• W1950507937 hasAuthorship W1950507937A5054934683 @default.
• W1950507937 hasAuthorship W1950507937A5055174666 @default.
• W1950507937 hasAuthorship W1950507937A5068026217 @default.
• W1950507937 hasAuthorship W1950507937A5080885941 @default.
• W1950507937 hasAuthorship W1950507937A5084926794 @default.
• W1950507937 hasBestOaLocation W19505079371 @default.
• W1950507937 hasConcept C121332964 @default.
• W1950507937 hasConcept C13373296 @default.
• W1950507937 hasConcept C153400128 @default.
• W1950507937 hasConcept C154317977 @default.
• W1950507937 hasConcept C159654299 @default.
• W1950507937 hasConcept C167672396 @default.
• W1950507937 hasConcept C185592680 @default.

• next