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- W1950566777 abstract "Forspiro® (F) is an innovative multi-dose DPI containing fluticasone/salmeterol; a proven and widely-used treatment for asthma and COPD.To evaluate flow profiles between different patient groups for F, and to compare device preference between F and Seretide™ Diskus™ (S-D) patients (pts) with asthma and COPD were assessed in an open-label, randomised, crossover study. Flow profiles were measured for F, and post-inhalation (empty blisters), safety and patient-reported outcomes were assessed for F and S-D.Using F, all 40 patients aged 15-77 years achieved minimum-recommended peak inspiratory flow rates of >30 L/min (Fig). Results were similar across all subgroups and secondary endpoints.![Figure][1] Internal resistance measured in vitro was 0.026 kPa0.5L/min for both devices.A pt-preference questionnaire regarding both DPIs at the final visit revealed comparably high overall satisfaction: preference with respect to mouthpiece comfort (F vs S-D) was 60.0 % vs 30.0 % and for mouthpiece assisting proper inhalation 50.0 % vs 32.5 %.The flow profile of an inhaler device affects drug delivery, so delivering doses consistently even at low flow rates is particularly important in all pts with respiratory disease.F reliably does so with high subject satisfaction: the mouthpiece preference for F was twice that for S-D. Thus, F is a suitable alternative for pts with asthma and COPD. [1]: pending:yes" @default.
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- W1950566777 date "2014-09-01" @default.
- W1950566777 modified "2023-09-28" @default.
- W1950566777 title "Comparison of inspiratory flow rates using an innovative dry powder inhaler (DPI) in patients with mild–severe asthma and severe COPD" @default.
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