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- W1950654444 abstract "Abstract Leptin is mainly produced by adipocytes and metabolized in the kidney. Leptin is taken up into the central nervous system by a saturable transport system, and controls appetite in rodents and in healthy subjects. Leptin acts on peripheral tissue and increases the inflammatory response by stimulating the production of tumor necrosis factor alpha, interleukin‐6 and interleukin‐12. In healthy humans, serum leptin concentration is related to the size of adipose tissue mass in the body. The majority of obese subjects have inappropriately high levels of circulating plasma leptin concentrations, indicating leptin resistance. In healthy subjects increased leptin concentration constitutes a biomarker for increased cardiovascular risk. On the other hand, a recent prospective long‐term study in patients with chronic kidney disease stage 5 on hemodialysis therapy showed that reduced serum leptin concentration is an independent risk factor for mortality in these patients." @default.
- W1950654444 created "2016-06-24" @default.
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- W1950654444 date "2007-08-08" @default.
- W1950654444 modified "2023-10-13" @default.
- W1950654444 title "CARDIOVASCULAR AND SURVIVAL PARADOXES IN DIALYSIS PATIENTS: Role of Leptin in Reverse Epidemiology in Chronic Kidney Disease" @default.
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- W1950654444 doi "https://doi.org/10.1111/j.1525-139x.2007.00334.x" @default.
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