Matches in SemOpenAlex for { <https://semopenalex.org/work/W195067654> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W195067654 endingPage "2069" @default.
- W195067654 startingPage "2061" @default.
- W195067654 abstract "Gou-teng is a drug used for treatment of hypertension in Chinese medicine. Its antihypertensive action has been previously confirmed in the spontaneously hypertensive rat (SHR). Here, its vasorelaxing effect and the mechanisms of actions were studied in vitro. Gou-teng extract (GTE) relaxed the norepinephrine (NE)-precontracted aortic ring preparations isolated from Wistar Kyoto rats (WKY) with and without intact endothelium; the latter was significantly less sensitive than the former. The GTE-induced endothelium-dependent relaxation was significantly inhibited by NG-monomethyl-L-arginine (NMMA) in a dose-dependent manner while indomethacin did not affect the relaxation. Atropine inhibited the acetylcholine (ACh)-induced endothelium-dependent relaxation but did not the GTE-induced one. Furthermore, once GTE was applied, the following NE-induced contraction was significantly reduced even after repeated washout. NMMA effectively reduced and rather reversed this residual effect of GTE. From these results, it is concluded that GTE relaxes the NE-precontracted rat aorta through endothelium-dependent and, to lesser extent, -independent mechanisms. The endothelium-dependent component would be mediated by EDRF/NO pathway in which the muscarinic cholinoceptors were not involved. Thus, GTE appears to be a potent and long-lasting vasodilator mainly through EDRF/NO release." @default.
- W195067654 created "2016-06-24" @default.
- W195067654 creator A5017068539 @default.
- W195067654 creator A5029217856 @default.
- W195067654 creator A5044723837 @default.
- W195067654 date "1994-01-01" @default.
- W195067654 modified "2023-09-25" @default.
- W195067654 title "Gou-teng (from Miquel)-induced endothelium-dependent and -independent relaxations in the isolated rat aorta" @default.
- W195067654 cites W1975567521 @default.
- W195067654 cites W1976145582 @default.
- W195067654 cites W1994950364 @default.
- W195067654 cites W2019716574 @default.
- W195067654 cites W2048635427 @default.
- W195067654 cites W2077798575 @default.
- W195067654 cites W2169182236 @default.
- W195067654 cites W2284590122 @default.
- W195067654 cites W2411856868 @default.
- W195067654 cites W3105976938 @default.
- W195067654 doi "https://doi.org/10.1016/0024-3205(94)00715-2" @default.
- W195067654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8208063" @default.
- W195067654 hasPublicationYear "1994" @default.
- W195067654 type Work @default.
- W195067654 sameAs 195067654 @default.
- W195067654 citedByCount "53" @default.
- W195067654 countsByYear W1950676542012 @default.
- W195067654 countsByYear W1950676542013 @default.
- W195067654 countsByYear W1950676542014 @default.
- W195067654 countsByYear W1950676542017 @default.
- W195067654 countsByYear W1950676542018 @default.
- W195067654 countsByYear W1950676542020 @default.
- W195067654 countsByYear W1950676542022 @default.
- W195067654 countsByYear W1950676542023 @default.
- W195067654 crossrefType "journal-article" @default.
- W195067654 hasAuthorship W195067654A5017068539 @default.
- W195067654 hasAuthorship W195067654A5029217856 @default.
- W195067654 hasAuthorship W195067654A5044723837 @default.
- W195067654 hasConcept C126322002 @default.
- W195067654 hasConcept C164705383 @default.
- W195067654 hasConcept C185592680 @default.
- W195067654 hasConcept C2776992346 @default.
- W195067654 hasConcept C2779980429 @default.
- W195067654 hasConcept C71924100 @default.
- W195067654 hasConcept C98274493 @default.
- W195067654 hasConceptScore W195067654C126322002 @default.
- W195067654 hasConceptScore W195067654C164705383 @default.
- W195067654 hasConceptScore W195067654C185592680 @default.
- W195067654 hasConceptScore W195067654C2776992346 @default.
- W195067654 hasConceptScore W195067654C2779980429 @default.
- W195067654 hasConceptScore W195067654C71924100 @default.
- W195067654 hasConceptScore W195067654C98274493 @default.
- W195067654 hasIssue "26" @default.
- W195067654 hasLocation W1950676541 @default.
- W195067654 hasOpenAccess W195067654 @default.
- W195067654 hasPrimaryLocation W1950676541 @default.
- W195067654 hasRelatedWork W1531601525 @default.
- W195067654 hasRelatedWork W2049397185 @default.
- W195067654 hasRelatedWork W2159512267 @default.
- W195067654 hasRelatedWork W2304633692 @default.
- W195067654 hasRelatedWork W2399063111 @default.
- W195067654 hasRelatedWork W2748952813 @default.
- W195067654 hasRelatedWork W2899084033 @default.
- W195067654 hasRelatedWork W2948807893 @default.
- W195067654 hasRelatedWork W3141700921 @default.
- W195067654 hasRelatedWork W2778153218 @default.
- W195067654 hasVolume "54" @default.
- W195067654 isParatext "false" @default.
- W195067654 isRetracted "false" @default.
- W195067654 magId "195067654" @default.
- W195067654 workType "article" @default.