FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1950697653> ?p ?o ?g. }

• W1950697653 endingPage "620" @default.
• W1950697653 startingPage "611" @default.
• W1950697653 abstract "Ginsenoside Rg3 is one of the active ingredients isolated from Panax ginseng C.A. Meyer. Previous studies demonstrated that Rg3 has antioxidant and neuroprotective abilities.The purpose of this study was to evaluate the protective effect of Rg3 on erectile function in streptozotocin (STZ)-induced diabetic rats.Two-month-old Sprague-Dawley male rats received a one-time intraperitoneal (IP) STZ (60 mg/kg) or vehicle injection after a 16-hour fast. Three days later, rats were randomly divided into four groups and were treated with daily gavage feedings of a mix of distilled saline water and 0.5% carboxymethylcellulose or Rg3 dissolved in the mix at doses of 10 mg/kg and 100 mg/kg for 3 months. A sham group underwent IP injection of saline followed by daily gavage of the above mix for 3 months.Erectile function was assessed by cavernosal nerve electrostimulation at 3 months. The penis was then harvested and deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was performed. Western blot was performed to examine cleaved caspase-3, platelet endothelial cell adhesion molecule (PECAM)-1, and smooth muscle actin (SMA). Neural regeneration was measured by nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase staining. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected by colorimetry.In the negative control group, the functional evaluation showed a lower mean intracavernosal pressure (ICP) with cavernosal nerve stimulation than in the sham group; there was a significant change in the expression of cleaved caspase-3, bcl-2, bcl-xl, PECAM-1, and SMA, as well as in the SOD and MDA production in the corpus cavernosum. Histological analysis of specimens stained for NADPH showed a significant change in the staining quality of the neurons in the dorsal nerves; TUNEL showed a greater apoptotic index in corpus cavernosum cells. With daily oral gavage with 100 mg/kg Rg3, the ICP/mean arterial pressure value was significantly higher than in the controls. The level of cleaved caspase-3, bcl-2, bcl-xl, PECAM-1, and SMA and the number of positively stained nerve fibers tended to revert to normal after Rg3 treatment. The apoptotic index in corpus cavernosum cells was lowered.Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats." @default.
• W1950697653 created "2016-06-24" @default.
• W1950697653 creator A5012677271 @default.
• W1950697653 creator A5030927792 @default.
• W1950697653 creator A5033234173 @default.
• W1950697653 creator A5044862362 @default.
• W1950697653 creator A5047100994 @default.
• W1950697653 creator A5057011805 @default.
• W1950697653 creator A5057297125 @default.
• W1950697653 date "2015-03-01" @default.
• W1950697653 modified "2023-09-29" @default.
• W1950697653 title "Ginsenoside Rg3 Improves Erectile Function in Streptozotocin-Induced Diabetic Rats" @default.
• W1950697653 cites W1821918060 @default.
• W1950697653 cites W1824909668 @default.
• W1950697653 cites W1972027018 @default.
• W1950697653 cites W1972069476 @default.
• W1950697653 cites W1982929167 @default.
• W1950697653 cites W1990048810 @default.
• W1950697653 cites W1995089262 @default.
• W1950697653 cites W2007541306 @default.
• W1950697653 cites W2013322023 @default.
• W1950697653 cites W2022738955 @default.
• W1950697653 cites W2022873258 @default.
• W1950697653 cites W2024230975 @default.
• W1950697653 cites W2026068996 @default.
• W1950697653 cites W2052621304 @default.
• W1950697653 cites W2062502442 @default.
• W1950697653 cites W2069510249 @default.
• W1950697653 cites W2074584000 @default.
• W1950697653 cites W2095131213 @default.
• W1950697653 cites W2111823813 @default.
• W1950697653 cites W2120293565 @default.
• W1950697653 cites W2122342236 @default.
• W1950697653 cites W2124559568 @default.
• W1950697653 cites W2136252004 @default.
• W1950697653 cites W2138453316 @default.
• W1950697653 cites W2154345609 @default.
• W1950697653 cites W2156547717 @default.
• W1950697653 cites W2161440623 @default.
• W1950697653 cites W2469802091 @default.
• W1950697653 cites W4211128726 @default.
• W1950697653 doi "https://doi.org/10.1111/jsm.12779" @default.
• W1950697653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25442300" @default.
• W1950697653 hasPublicationYear "2015" @default.
• W1950697653 type Work @default.
• W1950697653 sameAs 1950697653 @default.
• W1950697653 citedByCount "18" @default.
• W1950697653 countsByYear W19506976532015 @default.
• W1950697653 countsByYear W19506976532016 @default.
• W1950697653 countsByYear W19506976532017 @default.
• W1950697653 countsByYear W19506976532018 @default.
• W1950697653 countsByYear W19506976532019 @default.
• W1950697653 countsByYear W19506976532020 @default.
• W1950697653 countsByYear W19506976532021 @default.
• W1950697653 countsByYear W19506976532022 @default.
• W1950697653 countsByYear W19506976532023 @default.
• W1950697653 crossrefType "journal-article" @default.
• W1950697653 hasAuthorship W1950697653A5012677271 @default.
• W1950697653 hasAuthorship W1950697653A5030927792 @default.
• W1950697653 hasAuthorship W1950697653A5033234173 @default.
• W1950697653 hasAuthorship W1950697653A5044862362 @default.
• W1950697653 hasAuthorship W1950697653A5047100994 @default.
• W1950697653 hasAuthorship W1950697653A5057011805 @default.
• W1950697653 hasAuthorship W1950697653A5057297125 @default.
• W1950697653 hasConcept C126322002 @default.
• W1950697653 hasConcept C134018914 @default.
• W1950697653 hasConcept C154113507 @default.
• W1950697653 hasConcept C181199279 @default.
• W1950697653 hasConcept C185592680 @default.
• W1950697653 hasConcept C196795494 @default.
• W1950697653 hasConcept C204232928 @default.
• W1950697653 hasConcept C2775838275 @default.
• W1950697653 hasConcept C2776151105 @default.
• W1950697653 hasConcept C2777397205 @default.
• W1950697653 hasConcept C2777989768 @default.
• W1950697653 hasConcept C2778401633 @default.
• W1950697653 hasConcept C2779280383 @default.
• W1950697653 hasConcept C2780159080 @default.
• W1950697653 hasConcept C38485361 @default.
• W1950697653 hasConcept C55493867 @default.
• W1950697653 hasConcept C555293320 @default.
• W1950697653 hasConcept C71924100 @default.
• W1950697653 hasConcept C98274493 @default.
• W1950697653 hasConceptScore W1950697653C126322002 @default.
• W1950697653 hasConceptScore W1950697653C134018914 @default.
• W1950697653 hasConceptScore W1950697653C154113507 @default.
• W1950697653 hasConceptScore W1950697653C181199279 @default.
• W1950697653 hasConceptScore W1950697653C185592680 @default.
• W1950697653 hasConceptScore W1950697653C196795494 @default.
• W1950697653 hasConceptScore W1950697653C204232928 @default.
• W1950697653 hasConceptScore W1950697653C2775838275 @default.
• W1950697653 hasConceptScore W1950697653C2776151105 @default.
• W1950697653 hasConceptScore W1950697653C2777397205 @default.
• W1950697653 hasConceptScore W1950697653C2777989768 @default.
• W1950697653 hasConceptScore W1950697653C2778401633 @default.
• W1950697653 hasConceptScore W1950697653C2779280383 @default.
• W1950697653 hasConceptScore W1950697653C2780159080 @default.
• W1950697653 hasConceptScore W1950697653C38485361 @default.

• next