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• W1950967546 endingPage "2871" @default.
• W1950967546 startingPage "2862" @default.
• W1950967546 abstract "Dendritic cells (DCs) are considered as key mediators of the early events in HIV-1 infection at mucosal sites. Although several aspects of the complex interactions between DCs and HIV-1 have been elucidated, there are still basic questions that remain to be answered about DCs/HIV-1 interplay. In this study, we examined the contribution of nonreceptor TKs in the known ability of DCs to efficiently transfer HIV-1 to CD4(+) T cells in trans. Experiments performed with specific inhibitors of Src and Syk family members indicate that these tyrosine kinases (TKs) are participating to HIV-1 transfer from immature monocyte-derived DCs (IM-MDDCs) to autologous CD4(+) T cells. Experiments with IM-MDDCs transfected with small interfering RNAs targeting Lyn and Syk confirmed the importance of these nonreceptor TKs in HIV-1 transmission. The Src- and Syk-mediated effect on virus transfer was linked with infection of IM-MDDCs in cis-as monitored by quantifying integrated viral DNA and de novo virus production. The process of HIV-1 transmission from IM-MDDCs to CD4(+) T cells was unaffected following treatment with protein kinase C and protein kinase A inhibitors. These data suggest that Src and Syk TKs play a functional role in productive HIV-1 infection of IM-MDDCs. Additional work is needed to facilitate our comprehension of the various mechanisms underlying the exact contribution of Src and Syk TKs to this phenomenon." @default.
• W1950967546 created "2016-06-24" @default.
• W1950967546 creator A5036236730 @default.
• W1950967546 creator A5039852039 @default.
• W1950967546 creator A5071127788 @default.
• W1950967546 creator A5085204114 @default.
• W1950967546 date "2007-03-01" @default.
• W1950967546 modified "2023-09-27" @default.
• W1950967546 title "Involvement of Src and Syk Tyrosine Kinases in HIV-1 Transfer from Dendritic Cells to CD4+ T Lymphocytes" @default.
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• W1950967546 doi "https://doi.org/10.4049/jimmunol.178.5.2862" @default.
• W1950967546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17312130" @default.
• W1950967546 hasPublicationYear "2007" @default.
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• W1950967546 citedByCount "29" @default.

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