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• W1951026329 endingPage "1782" @default.
• W1951026329 startingPage "1773" @default.
• W1951026329 abstract "Inhibitors that target the retroviral enzyme reverse transcriptase (RT) have played an indispensable role in the treatment and prevention of HIV-1 infection. They can be grouped into two distinct therapeutic groups, namely the nucleoside and nucleotide RT inhibitors (NRTIs), and the non-nucleoside RT inhibitors (NNRTIs). NRTIs form the backbones of most first- and second-line antiretroviral therapy (ART) regimens formulated for the treatment of HIV-1 infection. They are also used to prevent mother-to-child transmission, and as pre-exposure prophylaxis in individuals at risk of HIV-1 infection. The NNRTIs nevirapine (NVP), efavirenz and rilpivirine also used to form part of first-line ART regimens, although this is no longer recommended, while etravirine can be used in salvage ART regimens. A single-dose of NVP administered to both mother and child has routinely been used in resource-limited settings to reduce the rate of HIV-1 transmission. Unfortunately, the development of HIV-1 resistance to RT inhibitors can compromise the efficacy of these antiviral drugs in both the treatment and prevention arenas. Here, we provide an up-to-date review on drug-resistance mutations in HIV-1 RT, and discuss their cross-resistance profiles, molecular mechanisms and clinical significance." @default.
• W1951026329 created "2016-06-24" @default.
• W1951026329 creator A5029881635 @default.
• W1951026329 creator A5044933366 @default.
• W1951026329 creator A5087052821 @default.
• W1951026329 date "2015-11-01" @default.
• W1951026329 modified "2023-10-17" @default.
• W1951026329 title "Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection" @default.
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• W1951026329 doi "https://doi.org/10.2217/fmb.15.106" @default.
• W1951026329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4813512" @default.
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• W1951026329 hasPublicationYear "2015" @default.
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