FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1951139922> ?p ?o ?g. }

• W1951139922 endingPage "754" @default.
• W1951139922 startingPage "743" @default.
• W1951139922 abstract "Summary The outer membrane channel TolC is a key component of multidrug efflux and type I secretion transporters in Escherichia coli . Mutational inactivation of TolC renders cells highly susceptible to antibiotics and leads to defects in secretion of protein toxins. Despite impairment of various transport functions, no growth defects were reported in cells lacking TolC. Unexpectedly, we found that the loss of TolC notably impairs cell division and growth in minimal glucose medium. The TolC‐dependent phenotype was further exacerbated by the loss of ygiB and ygiC genes expressed in the same operon as tolC and their homologues yjfM and yjfC located elsewhere on the chromosome. Our results show that this growth deficiency is caused by depletion of the critical metabolite NAD + and high NADH/NAD + ratios. The increased amounts of PspA and decreased rates of NADH oxidation in Δ tolC membranes indicated stress on the membrane and dissipation of a proton motive force. We conclude that inactivation of TolC triggers metabolic shutdown in E. coli cells grown in minimal glucose medium. The Δ tolC phenotype is partially rescued by YgiBC and YjfMC, which have parallel functions independent from TolC." @default.
• W1951139922 created "2016-06-24" @default.
• W1951139922 creator A5023993045 @default.
• W1951139922 creator A5070008549 @default.
• W1951139922 date "2010-07-18" @default.
• W1951139922 modified "2023-10-16" @default.
• W1951139922 title "Metabolic shutdown in Escherichia coli cells lacking the outer membrane channel TolC" @default.
• W1951139922 cites W1529130961 @default.
• W1951139922 cites W1534819418 @default.
• W1951139922 cites W1555683147 @default.
• W1951139922 cites W1557008637 @default.
• W1951139922 cites W1562400216 @default.
• W1951139922 cites W1563103338 @default.
• W1951139922 cites W1573720837 @default.
• W1951139922 cites W1577774689 @default.
• W1951139922 cites W1847150206 @default.
• W1951139922 cites W1967854006 @default.
• W1951139922 cites W1969887535 @default.
• W1951139922 cites W1983540356 @default.
• W1951139922 cites W1991257218 @default.
• W1951139922 cites W1991486683 @default.
• W1951139922 cites W1991640599 @default.
• W1951139922 cites W1992764122 @default.
• W1951139922 cites W2006365527 @default.
• W1951139922 cites W2018875196 @default.
• W1951139922 cites W2027016294 @default.
• W1951139922 cites W2030015794 @default.
• W1951139922 cites W2044538793 @default.
• W1951139922 cites W2046272640 @default.
• W1951139922 cites W2062518791 @default.
• W1951139922 cites W2073475312 @default.
• W1951139922 cites W2075325890 @default.
• W1951139922 cites W2077274589 @default.
• W1951139922 cites W2077596659 @default.
• W1951139922 cites W2077815188 @default.
• W1951139922 cites W2102855875 @default.
• W1951139922 cites W2113711341 @default.
• W1951139922 cites W2116137883 @default.
• W1951139922 cites W2118547777 @default.
• W1951139922 cites W2122124081 @default.
• W1951139922 cites W2122127748 @default.
• W1951139922 cites W2134108049 @default.
• W1951139922 cites W2160397161 @default.
• W1951139922 cites W2171672250 @default.
• W1951139922 cites W2172047707 @default.
• W1951139922 cites W2210156870 @default.
• W1951139922 cites W2312737632 @default.
• W1951139922 cites W758260955 @default.
• W1951139922 doi "https://doi.org/10.1111/j.1365-2958.2010.07245.x" @default.
• W1951139922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2909361" @default.
• W1951139922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20545840" @default.
• W1951139922 hasPublicationYear "2010" @default.
• W1951139922 type Work @default.
• W1951139922 sameAs 1951139922 @default.
• W1951139922 citedByCount "56" @default.
• W1951139922 countsByYear W19511399222012 @default.
• W1951139922 countsByYear W19511399222013 @default.
• W1951139922 countsByYear W19511399222014 @default.
• W1951139922 countsByYear W19511399222015 @default.
• W1951139922 countsByYear W19511399222016 @default.
• W1951139922 countsByYear W19511399222017 @default.
• W1951139922 countsByYear W19511399222018 @default.
• W1951139922 countsByYear W19511399222019 @default.
• W1951139922 countsByYear W19511399222020 @default.
• W1951139922 countsByYear W19511399222021 @default.
• W1951139922 countsByYear W19511399222023 @default.
• W1951139922 crossrefType "journal-article" @default.
• W1951139922 hasAuthorship W1951139922A5023993045 @default.
• W1951139922 hasAuthorship W1951139922A5070008549 @default.
• W1951139922 hasBestOaLocation W19511399221 @default.
• W1951139922 hasConcept C104317684 @default.
• W1951139922 hasConcept C112243037 @default.
• W1951139922 hasConcept C146587185 @default.
• W1951139922 hasConcept C171357686 @default.
• W1951139922 hasConcept C200082930 @default.
• W1951139922 hasConcept C203075996 @default.
• W1951139922 hasConcept C41625074 @default.
• W1951139922 hasConcept C49039625 @default.
• W1951139922 hasConcept C547475151 @default.
• W1951139922 hasConcept C55493867 @default.
• W1951139922 hasConcept C65871279 @default.
• W1951139922 hasConcept C86803240 @default.
• W1951139922 hasConcept C95444343 @default.
• W1951139922 hasConceptScore W1951139922C104317684 @default.
• W1951139922 hasConceptScore W1951139922C112243037 @default.
• W1951139922 hasConceptScore W1951139922C146587185 @default.
• W1951139922 hasConceptScore W1951139922C171357686 @default.
• W1951139922 hasConceptScore W1951139922C200082930 @default.
• W1951139922 hasConceptScore W1951139922C203075996 @default.
• W1951139922 hasConceptScore W1951139922C41625074 @default.
• W1951139922 hasConceptScore W1951139922C49039625 @default.
• W1951139922 hasConceptScore W1951139922C547475151 @default.
• W1951139922 hasConceptScore W1951139922C55493867 @default.
• W1951139922 hasConceptScore W1951139922C65871279 @default.
• W1951139922 hasConceptScore W1951139922C86803240 @default.
• W1951139922 hasConceptScore W1951139922C95444343 @default.
• W1951139922 hasIssue "3" @default.
• W1951139922 hasLocation W19511399221 @default.

• next