Matches in SemOpenAlex for { <https://semopenalex.org/work/W1951273541> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1951273541 endingPage "12" @default.
- W1951273541 startingPage "1" @default.
- W1951273541 abstract "The low solubility of pterins can drastically be improved by N2-acylation or formation of the N2-[(dimethylamino)methylene] derivatives. Both types of compounds can be alkylated under Mitsunobu conditions to form from N2-acylpterins (see 2 and 3) and their derivatives (see 5, 6, 8, 9, 11, 13, 15, and 17) selectively the O4-alkyl derivatives 22–31, whereas the electron-donating [(dimethylamino)methyleneamino function in 46–51 gives, in a selective reaction, the N(3)-substitution (→52–61). N2,N2-Dimethylpterins and 18 and 19 and N2-methylpterins 20 and 21 direct alkylation also to the O4-position (→32–35, 38 and 39). Deacylation can be achieved under very mild conditions by solvolysis with MeOH (22→40, 26→41), and displacement of the O4-[2-(4-nitrophenyl)ethyl] group proceeds with ammonia at room temperature to the corresponding pteridin-2,4-diamines 42–45. Cleavage of the N2-[(dimethylamino)methylene] group works well with ammonia (→62–67). The advantage of applying the 2-(4-nitrophenyl)ethyl (npe) group as blocking group is seen in its selective removal by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under aprotic conditions without harming the other substituents." @default.
- W1951273541 created "2016-06-24" @default.
- W1951273541 creator A5076171741 @default.
- W1951273541 creator A5085302392 @default.
- W1951273541 date "2003-01-01" @default.
- W1951273541 modified "2023-10-14" @default.
- W1951273541 title "Pteridines, Part CXIII" @default.
- W1951273541 cites W1568135304 @default.
- W1951273541 cites W1965511914 @default.
- W1951273541 cites W1987484575 @default.
- W1951273541 cites W1990734966 @default.
- W1951273541 cites W2000114677 @default.
- W1951273541 cites W2016593198 @default.
- W1951273541 cites W2019994526 @default.
- W1951273541 cites W2054858483 @default.
- W1951273541 cites W2071504971 @default.
- W1951273541 cites W2093316123 @default.
- W1951273541 cites W2170866179 @default.
- W1951273541 cites W2313803251 @default.
- W1951273541 cites W2329927422 @default.
- W1951273541 doi "https://doi.org/10.1002/hlca.200390025" @default.
- W1951273541 hasPublicationYear "2003" @default.
- W1951273541 type Work @default.
- W1951273541 sameAs 1951273541 @default.
- W1951273541 citedByCount "20" @default.
- W1951273541 countsByYear W19512735412012 @default.
- W1951273541 countsByYear W19512735412013 @default.
- W1951273541 countsByYear W19512735412014 @default.
- W1951273541 countsByYear W19512735412015 @default.
- W1951273541 countsByYear W19512735412017 @default.
- W1951273541 countsByYear W19512735412018 @default.
- W1951273541 countsByYear W19512735412021 @default.
- W1951273541 crossrefType "journal-article" @default.
- W1951273541 hasAuthorship W1951273541A5076171741 @default.
- W1951273541 hasAuthorship W1951273541A5085302392 @default.
- W1951273541 hasConcept C127413603 @default.
- W1951273541 hasConcept C155574463 @default.
- W1951273541 hasConcept C155647269 @default.
- W1951273541 hasConcept C160964918 @default.
- W1951273541 hasConcept C161790260 @default.
- W1951273541 hasConcept C164361826 @default.
- W1951273541 hasConcept C175156509 @default.
- W1951273541 hasConcept C178790620 @default.
- W1951273541 hasConcept C185592680 @default.
- W1951273541 hasConcept C187320778 @default.
- W1951273541 hasConcept C193557335 @default.
- W1951273541 hasConcept C2776382133 @default.
- W1951273541 hasConcept C2777454769 @default.
- W1951273541 hasConcept C2779244968 @default.
- W1951273541 hasConcept C2779293432 @default.
- W1951273541 hasConcept C2780263894 @default.
- W1951273541 hasConcept C43369102 @default.
- W1951273541 hasConcept C94412978 @default.
- W1951273541 hasConceptScore W1951273541C127413603 @default.
- W1951273541 hasConceptScore W1951273541C155574463 @default.
- W1951273541 hasConceptScore W1951273541C155647269 @default.
- W1951273541 hasConceptScore W1951273541C160964918 @default.
- W1951273541 hasConceptScore W1951273541C161790260 @default.
- W1951273541 hasConceptScore W1951273541C164361826 @default.
- W1951273541 hasConceptScore W1951273541C175156509 @default.
- W1951273541 hasConceptScore W1951273541C178790620 @default.
- W1951273541 hasConceptScore W1951273541C185592680 @default.
- W1951273541 hasConceptScore W1951273541C187320778 @default.
- W1951273541 hasConceptScore W1951273541C193557335 @default.
- W1951273541 hasConceptScore W1951273541C2776382133 @default.
- W1951273541 hasConceptScore W1951273541C2777454769 @default.
- W1951273541 hasConceptScore W1951273541C2779244968 @default.
- W1951273541 hasConceptScore W1951273541C2779293432 @default.
- W1951273541 hasConceptScore W1951273541C2780263894 @default.
- W1951273541 hasConceptScore W1951273541C43369102 @default.
- W1951273541 hasConceptScore W1951273541C94412978 @default.
- W1951273541 hasIssue "1" @default.
- W1951273541 hasLocation W19512735411 @default.
- W1951273541 hasOpenAccess W1951273541 @default.
- W1951273541 hasPrimaryLocation W19512735411 @default.
- W1951273541 hasRelatedWork W1951273541 @default.
- W1951273541 hasRelatedWork W1991689170 @default.
- W1951273541 hasRelatedWork W1996215217 @default.
- W1951273541 hasRelatedWork W2082919581 @default.
- W1951273541 hasRelatedWork W2095148267 @default.
- W1951273541 hasRelatedWork W2320099635 @default.
- W1951273541 hasRelatedWork W2949362805 @default.
- W1951273541 hasRelatedWork W2949545772 @default.
- W1951273541 hasRelatedWork W2953155228 @default.
- W1951273541 hasRelatedWork W353769993 @default.
- W1951273541 hasVolume "86" @default.
- W1951273541 isParatext "false" @default.
- W1951273541 isRetracted "false" @default.
- W1951273541 magId "1951273541" @default.
- W1951273541 workType "article" @default.