FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1951453186> ?p ?o ?g. }

• W1951453186 endingPage "26" @default.
• W1951453186 startingPage "14" @default.
• W1951453186 abstract "Asthma and chronic obstructive pulmonary disease (COPD) are complex conditions with imprecise definitions, which make definitive morphological comparisons difficult. The airways in asthma are occluded by tenacious plugs of exudate and mucus, and there is fragility of airway surface epithelium, thickening of the reticular layer beneath the epithelial basal lamina (the last two not usually features of COPD), and bronchial vessel congestion and oedema. There is an increased inflammatory infiltrate comprising ‘activated’ lymphocytes and eosinophils with release of granular content in the latter, and enlargement of bronchial smooth muscle, particularly in medium‐sized bronchi. CD4 + ve lymphocytes predominate over CD8 + ve cells and neutrophils are sparse. In contrast, three conditions contribute to COPD. In chronic bronchitis there is cough and mucous hypersecretion with enlargement of tracheobronchial submucosal glands and a disproportionate increase of mucous acini. CD8 + ve lymphocytes predominate over CD4 + ve cells and there are increased numbers of subepithelial macrophages and intra‐epithelial neutrophils. Exacerbations of bronchitis are associated with a tissue eosinophilia, apparent absence of IL‐5 protein but gene expression for IL‐4 and IL‐5 is present. In small or peripheral airways disease, there is inflammation of bronchioli and mucous metaplasia and hyperplasia, with increased intraluminal mucus, increased wall muscle, fibrosis, and airway stenoses (also referred to as chronic obstructive bronchiolitis). Respiratory bronchiolitis involving increased numbers of pigmented macrophages is a critically important early lesion. Increasingly severe peribronchiolitis includes infiltration of T lymphocytes in which the CD8 + subset again predominates. These inflammatory changes may predispose to the development of centrilobular emphysema and reduced FEV 1 via the destruction of alveolar attachments. In emphysema there is abnormal, permanent enlargement of airspaces distal to the terminal bronchiolus (i.e. within the acinus) accompanied by destruction of alveolar walls and without obvious fibrosis. The severity of emphysema, rather than type, appears to be the most important determinant of chronic deterioration of airflow, and in this there may be significant loss of elastic recoil and microscopic emphysema prior to the observed macroscopic destruction of the acinus." @default.
• W1951453186 created "2016-06-24" @default.
• W1951453186 creator A5007986401 @default.
• W1951453186 date "1999-06-01" @default.
• W1951453186 modified "2023-10-18" @default.
• W1951453186 title "Differences and similarities between chronic obstructive pulmonary disease and asthma" @default.
• W1951453186 cites W128267528 @default.
• W1951453186 cites W1574273384 @default.
• W1951453186 cites W1892949664 @default.
• W1951453186 cites W1966224713 @default.
• W1951453186 cites W1970145958 @default.
• W1951453186 cites W1974234058 @default.
• W1951453186 cites W1977093939 @default.
• W1951453186 cites W1980210905 @default.
• W1951453186 cites W1981406087 @default.
• W1951453186 cites W1995396295 @default.
• W1951453186 cites W1996214993 @default.
• W1951453186 cites W2000384489 @default.
• W1951453186 cites W2002641136 @default.
• W1951453186 cites W2003855023 @default.
• W1951453186 cites W2004280557 @default.
• W1951453186 cites W2011267749 @default.
• W1951453186 cites W2017370657 @default.
• W1951453186 cites W2018123076 @default.
• W1951453186 cites W2020556896 @default.
• W1951453186 cites W2021451119 @default.
• W1951453186 cites W2031880739 @default.
• W1951453186 cites W2031986309 @default.
• W1951453186 cites W2033380992 @default.
• W1951453186 cites W2034475016 @default.
• W1951453186 cites W2035485014 @default.
• W1951453186 cites W2036327819 @default.
• W1951453186 cites W2036491602 @default.
• W1951453186 cites W2039889139 @default.
• W1951453186 cites W2047621648 @default.
• W1951453186 cites W2048059264 @default.
• W1951453186 cites W2051394653 @default.
• W1951453186 cites W2052140619 @default.
• W1951453186 cites W2062729120 @default.
• W1951453186 cites W2066083814 @default.
• W1951453186 cites W2068789291 @default.
• W1951453186 cites W2073432936 @default.
• W1951453186 cites W2075538838 @default.
• W1951453186 cites W2081920314 @default.
• W1951453186 cites W2085021685 @default.
• W1951453186 cites W2088196950 @default.
• W1951453186 cites W2089337998 @default.
• W1951453186 cites W2090456858 @default.
• W1951453186 cites W2099507082 @default.
• W1951453186 cites W2099969611 @default.
• W1951453186 cites W2116313488 @default.
• W1951453186 cites W2119374724 @default.
• W1951453186 cites W2123247629 @default.
• W1951453186 cites W2124006946 @default.
• W1951453186 cites W2124290866 @default.
• W1951453186 cites W2126475210 @default.
• W1951453186 cites W2136719349 @default.
• W1951453186 cites W2137471012 @default.
• W1951453186 cites W2138885254 @default.
• W1951453186 cites W2143238483 @default.
• W1951453186 cites W2148102009 @default.
• W1951453186 cites W2151206870 @default.
• W1951453186 cites W2153867520 @default.
• W1951453186 cites W2163424644 @default.
• W1951453186 cites W2164236314 @default.
• W1951453186 cites W2165981929 @default.
• W1951453186 cites W2168394796 @default.
• W1951453186 cites W2169813066 @default.
• W1951453186 cites W2288940328 @default.
• W1951453186 cites W2315018741 @default.
• W1951453186 cites W2319554819 @default.
• W1951453186 cites W2321320809 @default.
• W1951453186 cites W2336647043 @default.
• W1951453186 cites W2522612977 @default.
• W1951453186 cites W4241680892 @default.
• W1951453186 cites W58518567 @default.
• W1951453186 doi "https://doi.org/10.1046/j.1365-2222.1999.00004.x-i2" @default.
• W1951453186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10421818" @default.
• W1951453186 hasPublicationYear "1999" @default.
• W1951453186 type Work @default.
• W1951453186 sameAs 1951453186 @default.
• W1951453186 citedByCount "101" @default.
• W1951453186 countsByYear W19514531862012 @default.
• W1951453186 countsByYear W19514531862013 @default.
• W1951453186 countsByYear W19514531862014 @default.
• W1951453186 countsByYear W19514531862015 @default.
• W1951453186 countsByYear W19514531862016 @default.
• W1951453186 countsByYear W19514531862017 @default.
• W1951453186 countsByYear W19514531862018 @default.
• W1951453186 countsByYear W19514531862019 @default.
• W1951453186 countsByYear W19514531862020 @default.
• W1951453186 countsByYear W19514531862022 @default.
• W1951453186 crossrefType "journal-article" @default.
• W1951453186 hasAuthorship W1951453186A5007986401 @default.
• W1951453186 hasConcept C126322002 @default.
• W1951453186 hasConcept C142724271 @default.
• W1951453186 hasConcept C18903297 @default.
• W1951453186 hasConcept C203014093 @default.

• next