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- W195155027 abstract "Attempts to improve drug delivery have resulted in a range of sustained-release products for oral administration. A comprehensive study has been undertaken of the factors influencing the gastrointestinal transit of such preparations. The transits of solutions, tablets and osmotic devices have been compared with those of pellets. The systems were radiolabeled with either technetium-99m or indium (In-111 or In-113m) and administered to groups of healthy volunteers. The effects of particle size and density, and the presence of flood in the stomach, on gastric emptying and transit rates through the small intestine have been monitored using a gamma camera. Gastric residence was greatly influenced by the presence of food and the nature of the preparations. Transit time through the small intestine was independent of the size, shape or density of the material." @default.
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- W195155027 date "1984-01-01" @default.
- W195155027 modified "2023-09-27" @default.
- W195155027 title "Gastrointestinal transit of pharmaceutical preparations" @default.
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