Matches in SemOpenAlex for { <https://semopenalex.org/work/W1951891185> ?p ?o ?g. }
- W1951891185 endingPage "1119" @default.
- W1951891185 startingPage "1106" @default.
- W1951891185 abstract "Rifampicin resistance, a defining attribute of multidrug-resistant tuberculosis, is conferred by mutations in the β subunit of RNA polymerase. Sequencing of rifampicin-resistant (RIF-R) clinical isolates of Mycobacterium tuberculosis revealed, in addition to RIF-R mutations, enrichment of potential compensatory mutations around the double-psi β-barrel domain of the β' subunit comprising the catalytic site and the exit tunnel for newly synthesized RNA. Sequential introduction of the resistance allele followed by the compensatory allele in isogenic Mycobacterium smegmatis showed that these mutations respectively caused and compensated a starvation enhanced growth defect by altering RNA polymerase activity. While specific combinations of resistance and compensatory alleles converged in divergent lineages, other combinations recurred among related isolates suggesting transmission of compensated RIF-R strains. These findings suggest nutrient poor growth conditions impose larger selective pressure on RIF-R organisms that results in the selection of compensatory mutations in a domain involved in catalysis and starvation control of RNA polymerase transcription." @default.
- W1951891185 created "2016-06-24" @default.
- W1951891185 creator A5004260180 @default.
- W1951891185 creator A5005460851 @default.
- W1951891185 creator A5009494138 @default.
- W1951891185 creator A5018322506 @default.
- W1951891185 creator A5022985881 @default.
- W1951891185 creator A5027016088 @default.
- W1951891185 creator A5030106532 @default.
- W1951891185 creator A5035709398 @default.
- W1951891185 creator A5038069675 @default.
- W1951891185 creator A5043648393 @default.
- W1951891185 creator A5056632664 @default.
- W1951891185 creator A5057770186 @default.
- W1951891185 creator A5057925739 @default.
- W1951891185 creator A5060633154 @default.
- W1951891185 creator A5061392008 @default.
- W1951891185 creator A5063922861 @default.
- W1951891185 creator A5074151805 @default.
- W1951891185 creator A5075957872 @default.
- W1951891185 creator A5083230030 @default.
- W1951891185 creator A5086290702 @default.
- W1951891185 creator A5087777538 @default.
- W1951891185 creator A5089971701 @default.
- W1951891185 date "2014-02-26" @default.
- W1951891185 modified "2023-09-27" @default.
- W1951891185 title "Fitness costs of rifampicin resistance in<i>M</i><i>ycobacterium tuberculosis</i>are amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase" @default.
- W1951891185 cites W1514080071 @default.
- W1951891185 cites W1977999010 @default.
- W1951891185 cites W1980740976 @default.
- W1951891185 cites W1991175644 @default.
- W1951891185 cites W1995016187 @default.
- W1951891185 cites W2008186432 @default.
- W1951891185 cites W2011261850 @default.
- W1951891185 cites W2012515231 @default.
- W1951891185 cites W2032620844 @default.
- W1951891185 cites W2038567250 @default.
- W1951891185 cites W2044924241 @default.
- W1951891185 cites W2052377115 @default.
- W1951891185 cites W2056981303 @default.
- W1951891185 cites W2060248414 @default.
- W1951891185 cites W2066286375 @default.
- W1951891185 cites W2068028004 @default.
- W1951891185 cites W2068372433 @default.
- W1951891185 cites W2073556554 @default.
- W1951891185 cites W2075743405 @default.
- W1951891185 cites W2079497788 @default.
- W1951891185 cites W2086827484 @default.
- W1951891185 cites W2089335658 @default.
- W1951891185 cites W2090640084 @default.
- W1951891185 cites W2091915244 @default.
- W1951891185 cites W2093108941 @default.
- W1951891185 cites W2107277218 @default.
- W1951891185 cites W2107870109 @default.
- W1951891185 cites W2110088612 @default.
- W1951891185 cites W2114361924 @default.
- W1951891185 cites W2118233996 @default.
- W1951891185 cites W2118508196 @default.
- W1951891185 cites W2122402674 @default.
- W1951891185 cites W2124443090 @default.
- W1951891185 cites W2126568957 @default.
- W1951891185 cites W2135226086 @default.
- W1951891185 cites W2146581074 @default.
- W1951891185 cites W2150469424 @default.
- W1951891185 cites W2151925611 @default.
- W1951891185 cites W2158023121 @default.
- W1951891185 cites W2167988552 @default.
- W1951891185 cites W2327166516 @default.
- W1951891185 doi "https://doi.org/10.1111/mmi.12520" @default.
- W1951891185 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3951610" @default.
- W1951891185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24417450" @default.
- W1951891185 hasPublicationYear "2014" @default.
- W1951891185 type Work @default.
- W1951891185 sameAs 1951891185 @default.
- W1951891185 citedByCount "77" @default.
- W1951891185 countsByYear W19518911852014 @default.
- W1951891185 countsByYear W19518911852015 @default.
- W1951891185 countsByYear W19518911852016 @default.
- W1951891185 countsByYear W19518911852017 @default.
- W1951891185 countsByYear W19518911852018 @default.
- W1951891185 countsByYear W19518911852019 @default.
- W1951891185 countsByYear W19518911852020 @default.
- W1951891185 countsByYear W19518911852021 @default.
- W1951891185 countsByYear W19518911852022 @default.
- W1951891185 countsByYear W19518911852023 @default.
- W1951891185 crossrefType "journal-article" @default.
- W1951891185 hasAuthorship W1951891185A5004260180 @default.
- W1951891185 hasAuthorship W1951891185A5005460851 @default.
- W1951891185 hasAuthorship W1951891185A5009494138 @default.
- W1951891185 hasAuthorship W1951891185A5018322506 @default.
- W1951891185 hasAuthorship W1951891185A5022985881 @default.
- W1951891185 hasAuthorship W1951891185A5027016088 @default.
- W1951891185 hasAuthorship W1951891185A5030106532 @default.
- W1951891185 hasAuthorship W1951891185A5035709398 @default.
- W1951891185 hasAuthorship W1951891185A5038069675 @default.
- W1951891185 hasAuthorship W1951891185A5043648393 @default.
- W1951891185 hasAuthorship W1951891185A5056632664 @default.
- W1951891185 hasAuthorship W1951891185A5057770186 @default.