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• W1951931436 abstract "Mesenchymal stem cells (MSC) generated from human umbilical cord (UC-MSC) and placenta (PLC-MSC) were assessed and compared for their immunomodulatory function on T cells proliferation by analysis of the cell cycle. Mitogen stimulated or resting T cells were co-cultured in the presence or absence of MSC. T-cell proliferation was assessed by tritiated thymidine (3H-TdR) assay and the mechanism of inhibition was examined bycell cycle and apoptosis assay. Both UC-MSC and PLC-MSC profoundly inhibited the proliferation of T-cell, mainly via cell-to-cell contact. MSC-mediated anti-proliferation does not lead to apoptosis,but prevented T cells from entering S phase and they therefore accumulated in the G0/G1 phases. The anti-proliferative activity of MSC was related to this cell cycle arrest of T-cell. UC-MSC produced a greater inhibition than PLC-MSC in all measured parameters." @default.
• W1951931436 created "2016-06-24" @default.
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• W1951931436 date "2013-01-30" @default.
• W1951931436 modified "2023-09-28" @default.
• W1951931436 title "Mesenchymal stem cells of human placenta and umbilical cord suppress T-cell proliferation at G₀phase of cell cycle" @default.
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• W1951931436 doi "https://doi.org/10.1002/cbin.10033" @default.
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