FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1951935305> ?p ?o ?g. }

• W1951935305 endingPage "479" @default.
• W1951935305 startingPage "464" @default.
• W1951935305 abstract "Tissue factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium tuberculosis (M. tb) infection by using mice lacking the TF gene in myeloid cells (TFΔ) and human monocyte derived macrophages (MDMs). We found that during M. tb infection, a deficiency of TF in myeloid cells was associated with reduced inducible nitric oxide synthase (iNOS) expression, enhanced arginase 1 (Arg1) expression, enhanced IL-10 production and reduced apoptosis in infected macrophages, which augmented M. tb growth. Our results demonstrate that a deficiency of TF in myeloid cells promotes M2-like phenotype in M .tb infected macrophages. A deficiency in TF expression by myeloid cells was also associated with reduced fibrin deposition and increased matrix metalloproteases (MMP)-2 and MMP-9 mediated inflammation in M. tb infected lungs. Our studies demonstrate that TF expressed by myeloid cells has newly recognized abilities to polarize macrophages and to regulate M. tb growth." @default.
• W1951935305 created "2016-06-24" @default.
• W1951935305 creator A5013968607 @default.
• W1951935305 creator A5028689738 @default.
• W1951935305 creator A5035375919 @default.
• W1951935305 creator A5048095291 @default.
• W1951935305 creator A5049504573 @default.
• W1951935305 creator A5049517782 @default.
• W1951935305 creator A5058225079 @default.
• W1951935305 creator A5059010919 @default.
• W1951935305 creator A5062546035 @default.
• W1951935305 creator A5064777131 @default.
• W1951935305 creator A5065654406 @default.
• W1951935305 creator A5066299156 @default.
• W1951935305 creator A5073419615 @default.
• W1951935305 creator A5080622545 @default.
• W1951935305 date "2015-11-10" @default.
• W1951935305 modified "2023-10-16" @default.
• W1951935305 title "Tissue factor expression by myeloid cells contributes to protective immune response against<i>Mycobacterium tuberculosis</i>infection" @default.
• W1951935305 cites W1495259154 @default.
• W1951935305 cites W1557672464 @default.
• W1951935305 cites W1706591859 @default.
• W1951935305 cites W178032782 @default.
• W1951935305 cites W183556408 @default.
• W1951935305 cites W1923917571 @default.
• W1951935305 cites W1957872489 @default.
• W1951935305 cites W1966574709 @default.
• W1951935305 cites W1972249515 @default.
• W1951935305 cites W1973758538 @default.
• W1951935305 cites W1976417809 @default.
• W1951935305 cites W1979606311 @default.
• W1951935305 cites W1980981309 @default.
• W1951935305 cites W1981898543 @default.
• W1951935305 cites W1988070702 @default.
• W1951935305 cites W1988707760 @default.
• W1951935305 cites W1992551577 @default.
• W1951935305 cites W1998518075 @default.
• W1951935305 cites W2000049562 @default.
• W1951935305 cites W2003425589 @default.
• W1951935305 cites W2009181334 @default.
• W1951935305 cites W2009399552 @default.
• W1951935305 cites W2021211454 @default.
• W1951935305 cites W2022995264 @default.
• W1951935305 cites W2031222068 @default.
• W1951935305 cites W2031508708 @default.
• W1951935305 cites W2031646822 @default.
• W1951935305 cites W2032868165 @default.
• W1951935305 cites W2034967434 @default.
• W1951935305 cites W2046193895 @default.
• W1951935305 cites W2047387802 @default.
• W1951935305 cites W2051139401 @default.
• W1951935305 cites W2053240156 @default.
• W1951935305 cites W2054472394 @default.
• W1951935305 cites W2060053956 @default.
• W1951935305 cites W2069293755 @default.
• W1951935305 cites W2070422986 @default.
• W1951935305 cites W2071723955 @default.
• W1951935305 cites W2071874640 @default.
• W1951935305 cites W2071970926 @default.
• W1951935305 cites W2074895894 @default.
• W1951935305 cites W2076147619 @default.
• W1951935305 cites W2077309716 @default.
• W1951935305 cites W2077405407 @default.
• W1951935305 cites W2079345912 @default.
• W1951935305 cites W2081359858 @default.
• W1951935305 cites W2081928591 @default.
• W1951935305 cites W2089035904 @default.
• W1951935305 cites W2091442643 @default.
• W1951935305 cites W2091588921 @default.
• W1951935305 cites W2094158785 @default.
• W1951935305 cites W2095592851 @default.
• W1951935305 cites W2096753207 @default.
• W1951935305 cites W2097062405 @default.
• W1951935305 cites W2099976849 @default.
• W1951935305 cites W2101672858 @default.
• W1951935305 cites W2104629425 @default.
• W1951935305 cites W2106965899 @default.
• W1951935305 cites W2117714031 @default.
• W1951935305 cites W2118543713 @default.
• W1951935305 cites W2120293851 @default.
• W1951935305 cites W2127852674 @default.
• W1951935305 cites W2129240547 @default.
• W1951935305 cites W2134468562 @default.
• W1951935305 cites W2136957752 @default.
• W1951935305 cites W2139897215 @default.
• W1951935305 cites W2140251070 @default.
• W1951935305 cites W2148021940 @default.
• W1951935305 cites W2148648687 @default.
• W1951935305 cites W2152545130 @default.
• W1951935305 cites W2155933329 @default.
• W1951935305 cites W2156024967 @default.
• W1951935305 cites W2156608020 @default.
• W1951935305 cites W2157907856 @default.
• W1951935305 cites W2160170120 @default.
• W1951935305 cites W2162815684 @default.
• W1951935305 cites W2164759142 @default.
• W1951935305 cites W2165536326 @default.
• W1951935305 cites W2166298859 @default.

• next