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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1952012149> ?p ?o ?g. }

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• W1952012149 abstract "IL-30, the p28 subunit of IL-27, interacts with EBV-induced gene 3 to form IL-27, which modulates both proinflammatory and anti-inflammatory responses during autoimmune or infectious disease. It also acts as a natural antagonist of gp130, thereby attenuating the signals of other gp130-associated cytokines. IL-30 regulation via LPS has been reported by others, but the intercellular communication that induces IL-30 expression is unknown. In this study, we show that treatment with anti-CD3/CD28 Abs plus CpG oligodeoxynucleotides induces robust expression of IL-30, whereas either treatment alone induces only low expression of IL-30. This observation in vitro mirrors the murine model in which administration of CpG under inflammatory conditions in vivo induces IL-30 expression. This robust induction of IL-30 occurs through the coordination of helper CD4(+) T cells and innate immune cells (e.g., macrophages) and, to a lesser degree, B cells via the CD40/CD154 signaling pathway. These findings reveal a previously unrecognized mechanism that integrates signaling pathways from T cells and macrophages at the cellular level to induce IL-30 expression." @default.
• W1952012149 created "2016-06-24" @default.
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• W1952012149 creator A5075631379 @default.
• W1952012149 date "2012-04-15" @default.
• W1952012149 modified "2023-10-16" @default.
• W1952012149 title "Coordination between TLR9 Signaling in Macrophages and CD3 Signaling in T Cells Induces Robust Expression of IL-30" @default.
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• W1952012149 doi "https://doi.org/10.4049/jimmunol.1100883" @default.
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