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• W1952055580 abstract "// Erik Vassella 1 , Stephanie Langsch 1 , Matthias S. Dettmer 1 , Cornelia Schlup 1 , Maja Neuenschwander 1 , Milo Frattini 2 , Mathias Gugger 1, 3 , Stephan C. Schäfer 1, 4 1 Institute of Pathology, University of Bern, Bern, Switzerland 2 Institute of Pathology, Locarno, Switzerland 3 Promed SA Laboratoire Medical, Fribourg, Switzerland 4 Institute of Pathology, University Hospital of Cologne, Cologne, Germany Correspondence to: Erik Vassella, e-mail: erik.vassella@pathology.unibe.ch Keywords: adenosquamous carcinoma, lung, next-generation sequencing, therapy-relevant mutation, microRNA Received: March 17, 2015      Accepted: May 15, 2015      Published: June 03, 2015 ABSTRACT Lung adenosquamous carcinoma is a particular subtype of non-small cell lung carcinoma that is defined by the coexistence of adenocarcinoma and squamous cell carcinoma components. The aim of this study was to assess the mutational profile in each component of 16 adenosquamous carcinoma samples from a Caucasian population by a combination of next generation sequencing using the cancer hotspot panel as well as the colon and lung cancer panel and FISH. Identified mutations were confirmed by Sanger sequencing of DNA from cancer cells of each component collected by Laser Capture microdissection. Mutations typical for adenocarcinoma as well as squamous cell carcinoma were identified. Driver mutations were predominantly in the trunk suggesting a monoclonal origin of adenosquamous carcinoma. Most remarkably, EGFR mutations and mutations in the PI3K signaling pathway, which accounted for 30% and 25% of tumors respectively, were more prevalent while KRAS mutations were less prevalent than expected for a Caucasian population. Surprisingly, expression of classifier miR-205 was intermediate between that of classical adenocarcinoma and squamous cell carcinoma suggesting that adenosquamous carcinoma is a transitional stage between these tumor types. The high prevalence of therapy-relevant targets opens new options of therapeutic intervention for adenosquamous carcinoma patients." @default.
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• W1952055580 date "2015-06-03" @default.
• W1952055580 modified "2023-09-27" @default.
• W1952055580 title "Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type?" @default.
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• W1952055580 doi "https://doi.org/10.18632/oncotarget.4163" @default.
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