Matches in SemOpenAlex for { <https://semopenalex.org/work/W1952668055> ?p ?o ?g. }
- W1952668055 endingPage "502" @default.
- W1952668055 startingPage "495" @default.
- W1952668055 abstract "Nasal immunization of normal mice with HIVgp160-encapsulated hemagglutinating virus of Japan (HVJ)-liposome induced high titers of gp160-specific neutralizing IgG in serum and IgA in nasal wash, saliva, fecal extract, and vaginal wash, along with both Th1- and Th2-type responses. HIVgp160-specific IgG- and IgA-producing cells were also detected in mononuclear cells isolated from spleen, nasal cavity, salivary gland, intestinal lamina propria, and vaginal tissue of nasally immunized mice. In addition, CD8(+) CTLs were induced in mice nasally immunized with gp160-HVJ-liposome. These findings suggest that two layers of effective HIV-specific humoral and cellular immunity, in mucosal and systemic sites, were induced by this nasal vaccine. In immunodeficient mice, nasal immunization with gp160-HVJ-liposome induced Ag-specific immune responses for the systemic and mucosal compartments of both Th1 (IFN-gamma(-/-)) and Th2 (IL-4(-/-)). In vitro Ag-specific serum IgG Ab and vaginal wash samples possessing IgA and IgG Abs that had been induced by nasal immunization with gp160-HVJ-liposome were able to neutralize a clinically isolated strain of HIV-MN strain isolated from Japanese hemophiliac patients. Taken together, these results suggest that, for the prevention and control of AIDS, nasally administered gp160-HVJ-liposome is a powerful immunization tool that induces necessary Ag-specific immune responses at different stages of HIV infection." @default.
- W1952668055 created "2016-06-24" @default.
- W1952668055 creator A5009463570 @default.
- W1952668055 creator A5010827392 @default.
- W1952668055 creator A5028603816 @default.
- W1952668055 creator A5037489912 @default.
- W1952668055 creator A5040132448 @default.
- W1952668055 creator A5044791422 @default.
- W1952668055 creator A5045683397 @default.
- W1952668055 creator A5082923252 @default.
- W1952668055 creator A5087178931 @default.
- W1952668055 creator A5089554474 @default.
- W1952668055 date "2003-01-01" @default.
- W1952668055 modified "2023-10-03" @default.
- W1952668055 title "HIV Mucosal Vaccine: Nasal Immunization with gp160-Encapsulated Hemagglutinating Virus of Japan-Liposome Induces Antigen-Specific CTLs and Neutralizing Antibody Responses" @default.
- W1952668055 cites W1509855562 @default.
- W1952668055 cites W1520506879 @default.
- W1952668055 cites W1521329782 @default.
- W1952668055 cites W1529615732 @default.
- W1952668055 cites W1536921710 @default.
- W1952668055 cites W1553961669 @default.
- W1952668055 cites W1886464987 @default.
- W1952668055 cites W1940046231 @default.
- W1952668055 cites W1963958510 @default.
- W1952668055 cites W1970077852 @default.
- W1952668055 cites W1970556688 @default.
- W1952668055 cites W1974138678 @default.
- W1952668055 cites W1975010250 @default.
- W1952668055 cites W1975826225 @default.
- W1952668055 cites W1977796860 @default.
- W1952668055 cites W1979426030 @default.
- W1952668055 cites W1998371035 @default.
- W1952668055 cites W2007282352 @default.
- W1952668055 cites W2022760428 @default.
- W1952668055 cites W2031808723 @default.
- W1952668055 cites W2038256546 @default.
- W1952668055 cites W2043388006 @default.
- W1952668055 cites W2044058829 @default.
- W1952668055 cites W2053262189 @default.
- W1952668055 cites W2067632663 @default.
- W1952668055 cites W2068953057 @default.
- W1952668055 cites W2073023385 @default.
- W1952668055 cites W2076423932 @default.
- W1952668055 cites W2077609820 @default.
- W1952668055 cites W2087445563 @default.
- W1952668055 cites W2109984164 @default.
- W1952668055 cites W2111759310 @default.
- W1952668055 cites W2114633010 @default.
- W1952668055 cites W2124445678 @default.
- W1952668055 cites W2130357302 @default.
- W1952668055 cites W2133813477 @default.
- W1952668055 cites W2135879611 @default.
- W1952668055 cites W2135953287 @default.
- W1952668055 cites W2147103967 @default.
- W1952668055 cites W2157873615 @default.
- W1952668055 cites W4236567066 @default.
- W1952668055 doi "https://doi.org/10.4049/jimmunol.170.1.495" @default.
- W1952668055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12496436" @default.
- W1952668055 hasPublicationYear "2003" @default.
- W1952668055 type Work @default.
- W1952668055 sameAs 1952668055 @default.
- W1952668055 citedByCount "74" @default.
- W1952668055 countsByYear W19526680552012 @default.
- W1952668055 countsByYear W19526680552013 @default.
- W1952668055 countsByYear W19526680552014 @default.
- W1952668055 countsByYear W19526680552015 @default.
- W1952668055 countsByYear W19526680552016 @default.
- W1952668055 countsByYear W19526680552018 @default.
- W1952668055 countsByYear W19526680552021 @default.
- W1952668055 countsByYear W19526680552022 @default.
- W1952668055 crossrefType "journal-article" @default.
- W1952668055 hasAuthorship W1952668055A5009463570 @default.
- W1952668055 hasAuthorship W1952668055A5010827392 @default.
- W1952668055 hasAuthorship W1952668055A5028603816 @default.
- W1952668055 hasAuthorship W1952668055A5037489912 @default.
- W1952668055 hasAuthorship W1952668055A5040132448 @default.
- W1952668055 hasAuthorship W1952668055A5044791422 @default.
- W1952668055 hasAuthorship W1952668055A5045683397 @default.
- W1952668055 hasAuthorship W1952668055A5082923252 @default.
- W1952668055 hasAuthorship W1952668055A5087178931 @default.
- W1952668055 hasAuthorship W1952668055A5089554474 @default.
- W1952668055 hasBestOaLocation W19526680551 @default.
- W1952668055 hasConcept C126322002 @default.
- W1952668055 hasConcept C142724271 @default.
- W1952668055 hasConcept C159047783 @default.
- W1952668055 hasConcept C159654299 @default.
- W1952668055 hasConcept C203014093 @default.
- W1952668055 hasConcept C2522874641 @default.
- W1952668055 hasConcept C2777310793 @default.
- W1952668055 hasConcept C2780801004 @default.
- W1952668055 hasConcept C504460877 @default.
- W1952668055 hasConcept C529295009 @default.
- W1952668055 hasConcept C71924100 @default.
- W1952668055 hasConcept C85663871 @default.
- W1952668055 hasConcept C8891405 @default.
- W1952668055 hasConceptScore W1952668055C126322002 @default.
- W1952668055 hasConceptScore W1952668055C142724271 @default.
- W1952668055 hasConceptScore W1952668055C159047783 @default.