FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1952783702> ?p ?o ?g. }

• W1952783702 endingPage "334" @default.
• W1952783702 startingPage "320" @default.
• W1952783702 abstract "Recent developments in our understanding of events underlying neurodegeneration across the central and peripheral nervous systems have highlighted the critical role that synapses play in the initiation and progression of neuronal loss. With the development of increasingly accurate and versatile animal models of neurodegenerative disease it has become apparent that disruption of synaptic form and function occurs comparatively early, preceding the onset of degenerative changes in the neuronal cell body. Yet, despite our increasing awareness of the importance of synapses in neurodegeneration, the mechanisms governing the particular susceptibility of distal neuronal processes are only now becoming clear. In this review we bring together recent developments in our understanding of cellular and molecular mechanisms regulating synaptic vulnerability. We have placed a particular focus on three major areas of research that have gained significant interest over the last few years: (i) the contribution of synaptic mitochondria to neurodegeneration; (ii) the contribution of pathways that modulate synaptic function; and (iii) regulation of synaptic degeneration by local posttranslational modifications such as ubiquitination. We suggest that targeting these organelles and pathways may be a productive way to develop synaptoprotective strategies applicable to a range of neurodegenerative conditions." @default.
• W1952783702 created "2016-06-24" @default.
• W1952783702 creator A5012971010 @default.
• W1952783702 creator A5042253588 @default.
• W1952783702 date "2013-04-25" @default.
• W1952783702 modified "2023-09-25" @default.
• W1952783702 title "Mechanisms underlying synaptic vulnerability and degeneration in neurodegenerative disease" @default.
• W1952783702 cites W1485012056 @default.
• W1952783702 cites W1518489158 @default.
• W1952783702 cites W1519306389 @default.
• W1952783702 cites W152417155 @default.
• W1952783702 cites W1570595295 @default.
• W1952783702 cites W1592407422 @default.
• W1952783702 cites W1886575365 @default.
• W1952783702 cites W1903704021 @default.
• W1952783702 cites W1905860502 @default.
• W1952783702 cites W1964104625 @default.
• W1952783702 cites W1967601924 @default.
• W1952783702 cites W1967779299 @default.
• W1952783702 cites W1969633806 @default.
• W1952783702 cites W1969669037 @default.
• W1952783702 cites W1969945563 @default.
• W1952783702 cites W1974359647 @default.
• W1952783702 cites W1974750801 @default.
• W1952783702 cites W1975794476 @default.
• W1952783702 cites W1977246689 @default.
• W1952783702 cites W1978853862 @default.
• W1952783702 cites W1980162202 @default.
• W1952783702 cites W1983509809 @default.
• W1952783702 cites W1983970230 @default.
• W1952783702 cites W1984826365 @default.
• W1952783702 cites W1985086460 @default.
• W1952783702 cites W1985474993 @default.
• W1952783702 cites W1986295281 @default.
• W1952783702 cites W1986932865 @default.
• W1952783702 cites W1989984769 @default.
• W1952783702 cites W1990752558 @default.
• W1952783702 cites W1991980982 @default.
• W1952783702 cites W1992683864 @default.
• W1952783702 cites W1993364839 @default.
• W1952783702 cites W1993696187 @default.
• W1952783702 cites W1994141638 @default.
• W1952783702 cites W1994547907 @default.
• W1952783702 cites W1994805165 @default.
• W1952783702 cites W1996764498 @default.
• W1952783702 cites W1997145609 @default.
• W1952783702 cites W1997203285 @default.
• W1952783702 cites W1997252714 @default.
• W1952783702 cites W2004182349 @default.
• W1952783702 cites W2006578754 @default.
• W1952783702 cites W2008859668 @default.
• W1952783702 cites W2010560063 @default.
• W1952783702 cites W2011754722 @default.
• W1952783702 cites W2012014117 @default.
• W1952783702 cites W2014194922 @default.
• W1952783702 cites W2017901987 @default.
• W1952783702 cites W2018407678 @default.
• W1952783702 cites W2020486984 @default.
• W1952783702 cites W2021752087 @default.
• W1952783702 cites W2022287604 @default.
• W1952783702 cites W2023227782 @default.
• W1952783702 cites W2023542615 @default.
• W1952783702 cites W2024386053 @default.
• W1952783702 cites W2025615154 @default.
• W1952783702 cites W2026928801 @default.
• W1952783702 cites W2027938923 @default.
• W1952783702 cites W2027949683 @default.
• W1952783702 cites W2028177630 @default.
• W1952783702 cites W2029287748 @default.
• W1952783702 cites W2031215168 @default.
• W1952783702 cites W2031280902 @default.
• W1952783702 cites W2031568733 @default.
• W1952783702 cites W2035171143 @default.
• W1952783702 cites W2038365300 @default.
• W1952783702 cites W2038858069 @default.
• W1952783702 cites W2039641203 @default.
• W1952783702 cites W2040891140 @default.
• W1952783702 cites W2042422091 @default.
• W1952783702 cites W2042575407 @default.
• W1952783702 cites W2043470805 @default.
• W1952783702 cites W2044190420 @default.
• W1952783702 cites W2045064847 @default.
• W1952783702 cites W2045066990 @default.
• W1952783702 cites W2046615147 @default.
• W1952783702 cites W2047460306 @default.
• W1952783702 cites W2048035225 @default.
• W1952783702 cites W2048358683 @default.
• W1952783702 cites W2049646029 @default.
• W1952783702 cites W2050163135 @default.
• W1952783702 cites W2050769762 @default.
• W1952783702 cites W2051339896 @default.
• W1952783702 cites W2051640368 @default.
• W1952783702 cites W2052004580 @default.
• W1952783702 cites W2052446584 @default.
• W1952783702 cites W2054485625 @default.
• W1952783702 cites W2055200157 @default.
• W1952783702 cites W2056958351 @default.
• W1952783702 cites W2058495283 @default.

• next