Matches in SemOpenAlex for { <https://semopenalex.org/work/W1953004014> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1953004014 endingPage "65" @default.
- W1953004014 startingPage "57" @default.
- W1953004014 abstract "This study was designed to test the idea that the redox state of sulfhydryl (SH)-groups in cell-membrane Ca2+ channels plays a pivotal role in Ca2+ influx, which in turn causes an increase in albumin permeability across the cultured monolayer of porcine pulmonary artery endothelial (PPAE) cells exposed to xanthine/xanthine oxidase (X/XO). Albumin permeability as well as the concentration of intracellular Ca2+ ([Ca2+]i) was increased by X/XO. A H2O2 scavenger (catalase), an iron chelator (o-phenanthroline), and a hydroxyl radical scavenger (dimethyl sulfoxide) inhibited these changes provoked by X/XO, in which intracellular iron-catalyzed hydroxyl radical generation was suggested to be involved. The increase in albumin permeability and [Ca2+]i continued once the PPAE cells were exposed to X/XO. The [Ca2+]i was decreased by a Ca2+ channel blocker, Ni2+, while the removal of Ni2+ increased [Ca2+]i again, suggesting the sustained Ca2+ influx through cell-membrane Ca2+ channels was responsible for the [Ca2+]i elevation. Ni2+ failed to inhibit albumin permeability sustained after the removal of X/XO. In contrast, SH-reducing agents (dithiothreitol and glutathione) inhibited the sustained permeability as well as Ca2+ influx. We concluded that the redox alteration of SH-groups in cell-membrane Ca2+ channels was involved in the increase in albumin permeability after exposure of the endothelial cells to oxidative stress." @default.
- W1953004014 created "2016-06-24" @default.
- W1953004014 creator A5014642732 @default.
- W1953004014 creator A5020411504 @default.
- W1953004014 creator A5022218831 @default.
- W1953004014 creator A5035847003 @default.
- W1953004014 creator A5060598845 @default.
- W1953004014 date "2000-03-01" @default.
- W1953004014 modified "2023-09-23" @default.
- W1953004014 title "Albumin permeability across endothelial cell monolayer exposed to reactive oxygen intermediates: involvement of reversible functional alteration of the cell membrane Ca2+ channels." @default.
- W1953004014 cites W102919716 @default.
- W1953004014 cites W1554460966 @default.
- W1953004014 cites W1776133235 @default.
- W1953004014 cites W1971631582 @default.
- W1953004014 cites W1973373753 @default.
- W1953004014 cites W1977766283 @default.
- W1953004014 cites W2055211611 @default.
- W1953004014 cites W2061354090 @default.
- W1953004014 cites W2075908085 @default.
- W1953004014 cites W2082803878 @default.
- W1953004014 cites W214317437 @default.
- W1953004014 cites W2158060338 @default.
- W1953004014 cites W2238440277 @default.
- W1953004014 cites W2253765481 @default.
- W1953004014 cites W2342764320 @default.
- W1953004014 cites W2412480912 @default.
- W1953004014 cites W2462285506 @default.
- W1953004014 cites W2413298817 @default.
- W1953004014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10824458" @default.
- W1953004014 hasPublicationYear "2000" @default.
- W1953004014 type Work @default.
- W1953004014 sameAs 1953004014 @default.
- W1953004014 citedByCount "1" @default.
- W1953004014 crossrefType "journal-article" @default.
- W1953004014 hasAuthorship W1953004014A5014642732 @default.
- W1953004014 hasAuthorship W1953004014A5020411504 @default.
- W1953004014 hasAuthorship W1953004014A5022218831 @default.
- W1953004014 hasAuthorship W1953004014A5035847003 @default.
- W1953004014 hasAuthorship W1953004014A5060598845 @default.
- W1953004014 hasConcept C120882062 @default.
- W1953004014 hasConcept C123012128 @default.
- W1953004014 hasConcept C12554922 @default.
- W1953004014 hasConcept C181199279 @default.
- W1953004014 hasConcept C185592680 @default.
- W1953004014 hasConcept C202751555 @default.
- W1953004014 hasConcept C2776125364 @default.
- W1953004014 hasConcept C2776151105 @default.
- W1953004014 hasConcept C2777824588 @default.
- W1953004014 hasConcept C2778102346 @default.
- W1953004014 hasConcept C2778979269 @default.
- W1953004014 hasConcept C2992270614 @default.
- W1953004014 hasConcept C41625074 @default.
- W1953004014 hasConcept C48349386 @default.
- W1953004014 hasConcept C538909803 @default.
- W1953004014 hasConcept C55493867 @default.
- W1953004014 hasConcept C79879829 @default.
- W1953004014 hasConcept C86803240 @default.
- W1953004014 hasConceptScore W1953004014C120882062 @default.
- W1953004014 hasConceptScore W1953004014C123012128 @default.
- W1953004014 hasConceptScore W1953004014C12554922 @default.
- W1953004014 hasConceptScore W1953004014C181199279 @default.
- W1953004014 hasConceptScore W1953004014C185592680 @default.
- W1953004014 hasConceptScore W1953004014C202751555 @default.
- W1953004014 hasConceptScore W1953004014C2776125364 @default.
- W1953004014 hasConceptScore W1953004014C2776151105 @default.
- W1953004014 hasConceptScore W1953004014C2777824588 @default.
- W1953004014 hasConceptScore W1953004014C2778102346 @default.
- W1953004014 hasConceptScore W1953004014C2778979269 @default.
- W1953004014 hasConceptScore W1953004014C2992270614 @default.
- W1953004014 hasConceptScore W1953004014C41625074 @default.
- W1953004014 hasConceptScore W1953004014C48349386 @default.
- W1953004014 hasConceptScore W1953004014C538909803 @default.
- W1953004014 hasConceptScore W1953004014C55493867 @default.
- W1953004014 hasConceptScore W1953004014C79879829 @default.
- W1953004014 hasConceptScore W1953004014C86803240 @default.
- W1953004014 hasIssue "1" @default.
- W1953004014 hasLocation W19530040141 @default.
- W1953004014 hasOpenAccess W1953004014 @default.
- W1953004014 hasPrimaryLocation W19530040141 @default.
- W1953004014 hasRelatedWork W1913915913 @default.
- W1953004014 hasRelatedWork W2026684616 @default.
- W1953004014 hasRelatedWork W2058209982 @default.
- W1953004014 hasRelatedWork W2132152194 @default.
- W1953004014 hasRelatedWork W2161014782 @default.
- W1953004014 hasRelatedWork W2415799310 @default.
- W1953004014 hasRelatedWork W2467845479 @default.
- W1953004014 hasRelatedWork W2609556843 @default.
- W1953004014 hasRelatedWork W41822398 @default.
- W1953004014 hasRelatedWork W2137564704 @default.
- W1953004014 hasVolume "49" @default.
- W1953004014 isParatext "false" @default.
- W1953004014 isRetracted "false" @default.
- W1953004014 magId "1953004014" @default.
- W1953004014 workType "article" @default.